DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and Sytl5

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_848016.1	Gene:	Sytl5 / 302538	RGDID:	631342	Length:	753	Species:	Rattus norvegicus

Alignment Length:	473	Identity:	112/473 - (23%)
Similarity:	181/473 - (38%)	Gaps:	114/473 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KKQSQHDASFPFQPTRRPT-AVRSPSGQPPHYLKKSPSPTGGKQMG--LLSPMQDQSTSPIAQPN 105
            :.:|:.|.|..|......| ::||.|  .|..|.|..:.....:.|  |:|.....:|..:|...
  Rat   322 RSRSELDLSESFAEDLEDTSSIRSRS--VPGALDKDLNSLEDTEDGVDLVSSRFSANTHSLASGL 384

  Fly   106 VKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKE 170
            ...|:.|       ..:..:.|.|.|.:....|| ||:.....||...|:|.:|
  Rat   385 STSSQAG-------SDRKRSYLHVPDADSDTTSL-NSMMSVYSETGDYGNVKVT----------- 430

  Fly   171 LTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVK 235
                      |.|...:.|..:...|.:.:..||.|       ..||       ..:..||.|||
  Rat   431 ----------GEILLHISYCYKTGGLYIFVKNCRNL-------AIGD-------EKKQRTDAYVK 471

  Fly   236 LQLLPDK--QHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVV 298
            ..|||||  .:|.||: :|...||.::|... |.::...|:..:|...:..:||:.|:..:|||.
  Rat   472 SYLLPDKTRNNKRKTK-IRTGTNPEFNETLK-YTISHTQLETRTLQLSVWHYDRFGRNSFLGEVE 534

  Fly   299 CPLTSIEIGDISKE--ALSISKEIQPRSLKIRAQGRGELLISLCWQP------------------ 343
            ....|....:...|  .|....|:.|   .|..|.:|||.|.|.:.|
  Rat   535 IAFDSWNFENPCDEWFVLQPKVELAP---DISLQYKGELTIVLRYIPPEENLIFPVEQPQGKKIF 596

  Fly   344 -----------AAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPV 397
                       :.|.|.|.:.:|:||..:...|.:|.:||.|||.:..:..|.||.|.|::::|.
  Rat   597 KKGKKKESPAISGGILEVFIKEAKNLTAVKAGGTSDSFVKGYLLPDDNKATKHKTAVVKKSVNPQ 661

  Fly   398 FNESFAFD--IPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNH------ 454
            :|..|.|.  .|      ..::...|||.:.|.:..:.|..:|.:.|    :|.:.::|
  Rat   662 WNHVFIFSGLYP------QDIQNACLELTIWDKEAFSSNIFLGGVRL----NSGSGISHGKAVDW 716

  Fly   455 ----------WNEVCNSP 462
                      |.::.::|
  Rat   717 MDSRGEEQRLWQKMADNP 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	39/146 (27%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	40/178 (22%)
Sytl5	NP_848016.1	FYVE_Slp5	62..108	CDD:277305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..188
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..283
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359		11/38 (29%)
		C2A_SLP-4_5	430..553	CDD:175995	38/159 (24%)
		C2B_SLP_1-2-3-4	567..745	CDD:175987	40/178 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810