DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and Sytl1

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_006239075.1	Gene:	Sytl1 / 297872	RGDID:	1310715	Length:	562	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	127/500 - (25%)
Similarity:	190/500 - (38%)	Gaps:	129/500 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LRNKKQSQHD-----------------------ASFPFQPTRRPTAVRSPSGQPPHYLKKSPSPT 82
            :|.||.|:.|                       .|.........|..:.|....|:.|.|..|..
  Rat   106 IRRKKSSKGDQALGSDGDGEAAGEDTIEEAEPRVSIKVAAPETHTETQEPDFSSPYVLTKVSSQE 170

  Fly    83 GGKQMGLLSPMQDQSTSPIAQPNVKYSE---EGDGPAQHAEQ----------------QNGNQLT 128
                    ...|||...  .|..|:.:|   |.| |.|.|||                :||.:..
  Rat   171 --------EEPQDQEAP--GQGGVQVAEADPELD-PEQEAEQESWPTPAQIKTTSKVLENGEETP 224

  Fly   129 VVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNG-KELTVTDQYGKL---GTIYFKLRY 189
                 ||..||...|        ::.|...:|:..:|:.. |.|:...:.|.:   |::.|.|||
  Rat   225 -----GLGPSLDRML--------SSSSSVSSLNSSTLSGSLKSLSGEAEAGPVQVRGSVLFSLRY 276

  Fly   190 LAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNT 254
            ......|.|.:|:|:||.                ...:..:|||||..||||||:|.||.|.:..
  Rat   277 EPGTGELRVQVIQCQGLA----------------AARRRRSDPYVKSYLLPDKQNKRKTSVKKRN 325

  Fly   255 RNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKE 319
            .||:::|... :.:...||....|...:...:...|:..:|||..||   :..:...||..:  .
  Rat   326 LNPIFNETLR-HSVQQADLPGRVLSLSVWHRESLGRNIFLGEVEVPL---DTWNWDSEATWL--P 384

  Fly   320 IQPR--SLKIRAQGRGELLISLCW---------QPAAGRLTVVLLKARNLPRMDVTGLADPYVKI 373
            :|||  :.......||.|.:||.:         ||.:|.|...:.:|:.|..:. .|..|.|::.
  Rat   385 LQPRIPTSPDELPSRGLLSLSLKYIPAGSEGGGQPPSGELHFWIKEAQGLVPLR-PGSLDTYIQC 448

  Fly   374 YLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAG-ASLEGVSLELMLLDWDRVTKNEVI 437
            .:|.:..|.::::|.|.:|:||||||.:..:|     |.| |.|.....||.|.|...:...::.
  Rat   449 SVLPDDSRASRQRTRVVRRSLSPVFNHTMVYD-----GFGPADLRQACAELSLWDHGALASRQLG 508

  Fly   438 G-RLELGGPNSSSTAL------------NHWNEVCNSPRRQIAEW 469
            | ||.||  ..||..|            ..|..:...|    .||
  Rat   509 GTRLSLG--TGSSYGLQVPWMDSTPEEKQLWQTLLEQP----CEW 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	40/145 (28%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	45/160 (28%)
Sytl1	XP_006239075.1	PHD_SF	35..>70	CDD:419867
		C2	267..386	CDD:417471	40/140 (29%)
		C2B_SLP_1-2-3-4	399..555	CDD:175987	45/160 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810