DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and PLA2G4D

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_828848.3	Gene:	PLA2G4D / 283748	HGNCID:	30038	Length:	818	Species:	Homo sapiens

Alignment Length:	105	Identity:	40/105 - (38%)
Similarity:	56/105 - (53%)	Gaps:	16/105 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 RGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSP 396
            :||  .|.|||     |||.:|:||||...|:...|||||.:.|  :.....|.||.....|..|
Human    15 QGE--ASTCWQ-----LTVRVLEARNLRWADLLSEADPYVILQL--STAPGMKFKTKTLTDTSHP 70

  Fly   397 VFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEV 436
            |:||:|.|.|.      :.::.| |||.:.|.|.||::::
Human    71 VWNEAFRFLIQ------SQVKNV-LELSIYDEDSVTEDDI 103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	40/105 (38%)
PLA2G4D	NP_828848.3	C2_cPLA2	23..141	CDD:176001	35/95 (37%)
		cPLA2_Grp-IVB-IVD-IVE-IVF	269..811	CDD:132840
		Substrate binding. /evidence=ECO:0000269\|PubMed:27220631, ECO:0007744\|PDB:5IXC, ECO:0007744\|PDB:5IZR	330..331
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810