DRSC/TRiP Functional Genomics Resources

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Protein Alignment Syt4 and PCLO

DIOPT Version :10

Sequence 1:NP_477464.1 Gene:Syt4 / 40876 FlyBaseID:FBgn0028400 Length:474 Species:Drosophila melanogaster
Sequence 2:XP_054213895.1 Gene:PCLO / 27445 HGNCID:13406 Length:5204 Species:Homo sapiens


Alignment Length:568 Identity:125/568 - (22%)
Similarity:213/568 - (37%) Gaps:186/568 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 MRLRNKKQSQHDASFPF-------QPTRRPTAVRSPSGQPP----HYLKKSPSPTGGKQMGL--- 89
            :||:.::....|.||..       :||..|  :....|:.|    :..::||....|:.||:   
Human  4315 LRLKAQEAEALDVSFSHASSSARTKPTSLP--ISQSRGRIPIVAQNSEEESPLSPVGQPMGMARA 4377

  Fly    90 ----LSPM----QDQSTSPIAQPNVK-----------YSEE------------GDGPAQHAEQQN 123
                |.|:    :||..|..:.|.|:           |..:            .|..|.|..::.
Human  4378 AAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREE 4442

  Fly   124 GN------QLTVVDGNGLKHSLHNSLHHS-PV----ETI--ANGS----------VTITLD--DH 163
            .:      :..:.:|:||...|...|.|| |:    |.|  .||.          :.||.|  ||
Human  4443 TDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQIIQMNGKTMHYIFPHARIKITRDSKDH 4507

  Fly   164 S---------LTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSS-GTGDI 218
            :         :..|||  :....|::|....|:                  ||  |||: .||.:
Human  4508 TVSGNGLGIRIVGGKE--IPGHSGEIGAYIAKI------------------LP--GGSAEQTGKL 4550

  Fly   219 PTGM-----NGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSL 278
            ..||     || ....:..|.::|.:..:|.......||...|.:.|.:         :.|::.|
Human  4551 MEGMQVLEWNG-IPLTSKTYEEVQSIISQQSGEAEICVRLDLNMLSDSE---------NSQHLEL 4605

  Fly   279 HFVILSFDRYSRDD--------------------VIGEVVCPLTSIEIGDISKEALSISKEIQPR 323
            |....:.|:.....                    |:..||...:.:..|..|..:.|:....||.
Human  4606 HEPPKAVDKAKSPGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQPG 4670

  Fly   324 SLKIRAQGR-----------------GELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYV 371
            |..:..:..                 ||:.:.:.:.  .|.|.:.:|:||||...|..|.:||:|
Human  4671 SPSVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYD--LGNLIIHILQARNLVPRDNNGYSDPFV 4733

  Fly   372 KIYLL---------YNGQRIAKKKT-HVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLL 426
            |:|||         .|.....|::| ||:| :|:|.:|::..:...:.|    .|:..:||:.:.
Human  4734 KVYLLPGRGQVMVVQNASAEYKRRTKHVQK-SLNPEWNQTVIYKSISME----QLKKKTLEVTVW 4793

  Fly   427 DWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHKLNE 474
            |:||.:.|:.:|.:.:   :.|||     :.:.|:||     |:.|.|
Human  4794 DYDRFSSNDFLGEVLI---DLSST-----SHLDNTPR-----WYPLKE 4828

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syt4NP_477464.1 C2A_Synaptotagmin-4-11 179..322 CDD:176034 30/168 (18%)
C2B_Synaptotagmin-4 332..473 CDD:176049 43/167 (26%)
PCLOXP_054213895.1 PRK07764 <32..411 CDD:236090
PHA03247 <309..905 CDD:223021
FYVE1_PCLO 587..648 CDD:277313
kgd 947..>1027 CDD:476867
FYVE2_PCLO 1057..1120 CDD:277315
PTZ00121 <1157..1700 CDD:173412
PRK10263 3461..>3966 CDD:236669
PDZ_RIM-like 4493..4588 CDD:467198 25/117 (21%)
C2A_RIM1alpha 4695..4827 CDD:175997 43/151 (28%)
C2 5087..5196 CDD:425499
Blue background indicates that the domain is not in the aligned region.

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