DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and Syt1

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001028852.2	Gene:	Syt1 / 25716	RGDID:	3803	Length:	421	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	145/462 - (31%)
Similarity:	224/462 - (48%)	Gaps:	120/462 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AILGLTAAAVLSSV-ACICARQMRLRNKKQSQHDASFPFQPTRRPTAVRSPSGQPPHYLKKSPSP 81
            |::.:...|||..| .|.|..:..|..||.                             ||....
  Rat    59 ALIAIAIVAVLLVVTCCFCVCKKCLFKKKN-----------------------------KKKGKE 94

  Fly    82 TGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSLHN-SLHH 145
            .|||                                       |.:.:.|...|..::.: :|..
  Rat    95 KGGK---------------------------------------NAINMKDVKDLGKTMKDQALKD 120

  Fly   146 SPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPC-- 208
            ...||             .||:|:|.....:..|||.:.:.|.|..:.|.|:|.||:...||.
  Rat   121 DDAET-------------GLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALD 172

  Fly   209 KGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDL 273
            .||:|                 |||||:.|||||:.|.:|:|.|.|.|||::|.||| .:..::|
  Rat   173 MGGTS-----------------DPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTF-KVPYSEL 219

  Fly   274 QNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKE---ALSISKEIQPRSLKIRAQGRGEL 335
            ...:|...:..|||:|:.|:|||...|:.:::.|.:::|   ..|..||.|.:        .|::
  Rat   220 GGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEK--------LGDI 276

  Fly   336 LISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNE 400
            ..||.:.|.||:||||:|:|:||.:|||.||:||||||:|:.||:|:.||||.:||.||:|.:||
  Rat   277 CFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNE 341

  Fly   401 SFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQ 465
            ||:|::|..:     ::.|.:.:.:||:|::.||:.||::.: |.||:...|.||:::..:|||.
  Rat   342 SFSFEVPFEQ-----IQKVQVVVTVLDYDKIGKNDAIGKVFV-GYNSTGAELRHWSDMLANPRRP 400

  Fly   466 IAEWHKL 472
            ||:||.|
  Rat   401 IAQWHTL 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	53/147 (36%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	66/141 (47%)
Syt1	NP_001028852.2	Syt1_N	5..112	CDD:409248	18/120 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..141		7/41 (17%)
		Phospholipid binding. /evidence=ECO:0000305	135..381		107/277 (39%)
		C2A_Synaptotagmin-1-5-6-9-10	142..264	CDD:176031	49/139 (35%)
		C2B_Synaptotagmin-1	273..408	CDD:176047	66/141 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820