DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and SYT14

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_006711325.1	Gene:	SYT14 / 255928	HGNCID:	23143	Length:	864	Species:	Homo sapiens

Alignment Length:	523	Identity:	117/523 - (22%)
Similarity:	199/523 - (38%)	Gaps:	127/523 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EEYIPDASVMDTIVPAILGLTAAAVLSSVACICARQMRLRNKKQSQHDASFPFQPTRRPTAVRSP 67
            ::|.|.::..|       |.::.|.:....||    .|:|..         |.....:|...:..
Human   417 QKYSPLSAEYD-------GYSSEASIDEGNCI----QRMRRT---------PPLDELQPPPYQDD 461

  Fly    68 SGQPPHYLKKSPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVDG 132
            ||.|  :|..:||..|..:    ......|.||....| |...||         ..|:::
Human   462 SGSP--HLSCTPSEIGDSK----CEFSHCSNSPRCSYN-KCPSEG---------STGHEI----- 505

  Fly   133 NGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQY-----GKLGTIYFKLRYLAE 192
                .|.||..:.   |.:.:.|..:...:.....|....:...:     .|.||:.....|.::
Human   506 ----ESFHNKGYE---EDVPSDSTAVLSPEDMSAQGSSSQLPKPFDPEPEAKYGTLDVTFDYDSQ 563

  Fly   193 RNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNP 257
            ...|:|::            :...||||  ..|| ......|.|.|||.|:.:.||.:.|.. .|
Human   564 EQKLLVTV------------TAVTDIPT--YNRT-GGNSWQVHLVLLPIKKQRAKTSIQRGP-CP 612

  Fly   258 VYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEI-GDIS----------- 310
            |:.|.|.|..:....:.|.::.|.:....|..::.::||.:..||.:.: |.:|
Human   613 VFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNH 677

  Fly   311 --------------KEALSISKEIQPRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRM 361
                          .|:.|..:.::..|:.       |:||.|.:....|||:..::|..:...:
Human   678 SGCDSQMSVSEMSCSESTSSCQSLEHGSVP-------EILIGLLYNATTGRLSAEVIKGSHFKNL 735

  Fly   362 -------------------DVTGLADPYVKIYLLYN-GQRIAKKKTHVKKRTLSPVFNESFAFDI 406
                               .|..:.|.|||:.||.: ||.::|.||.:::...:||:.|:|.|.:
Human   736 AANRPPNGLFCCLKHLIGGQVYIIRDTYVKLTLLNSMGQEMSKCKTSIRRGQPNPVYKETFVFQV 800

  Fly   407 PAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHK 471
                 |...|..|:|.|.:.:...:.:.|:||.:.||..:|....||||.|:..|..:|:..||.
Human   801 -----ALFQLSDVTLILSVYNKRSMKRKEMIGWISLGLNSSGEEELNHWTEMKESKGQQVCRWHA 860

  Fly   472 LNE 474
            |.|
Human   861 LLE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	37/168 (22%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	45/160 (28%)
SYT14	XP_006711325.1	C2A_Synaptotagmin-14_16	550..673	CDD:176035	35/138 (25%)
SYT14	XP_006711325.1	C2B_Synaptotagmin-14_16	706..862	CDD:176053	45/167 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810