DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and Syt2

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_038946276.1	Gene:	Syt2 / 24805	RGDID:	3804	Length:	499	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	148/469 - (31%)
Similarity:	228/469 - (48%)	Gaps:	104/469 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RRPTAVRSPSGQPPHYLKKSPSPTGGKQMGLLSPMQDQSTSPIA-QPNVKYSEEGDGPAQHAEQQ 122
            ||......||....:..|::..|       :::|....:|.|:| ...|..|.|..|..:..|..
  Rat    66 RRWAGPAVPSATMRNIFKRNQEP-------IVAPATTTATMPLAPAAPVDNSTESTGTGESQEDM 123

  Fly   123 NGNQLTVVDGNGLKHSLHNSLHHSPVE-------TIANGSVTITL-------------------- 160
            ...         ||....|.::..|:.       .:..|.:.:|.
  Rat   124 FAK---------LKDKFFNEINKIPLPPWALIAMAVVAGLLLLTCCFCICKKCCCKKKKNKKEKG 179

  Fly   161 ----------------DDHSLTNGKELTVTDQYGK-------LGTIYFKLRYLAERNALMVSIIR 202
                            ||.....|  ||..:..|:       ||.:.|.|.|..:.|.|.|.:::
  Rat   180 KGMKNAMNMKDMKGGQDDDDAETG--LTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQ 242

  Fly   203 CRGLPC--KGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTF 265
            ...||.  .||:|                 |||||:.|||||:.|.:|:|.|.|.||.::|.|||
  Rat   243 AAELPALDMGGTS-----------------DPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTF 290

  Fly   266 YGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKE--ALSISKEIQPRSLKIR 328
             .:...:|...:|...|..|||:|:.|:||||..|:.::::|...:|  .|...::.:|..|
  Rat   291 -KVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKL--- 351

  Fly   329 AQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRT 393
                |::..||.:.|.||:|||.:|:|:||.:|||.||:||||||:|:.||:|:.||||.|||:|
  Rat   352 ----GDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKT 412

  Fly   394 LSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEV 458
            |:|.|||||:|:||..:     ::.|.:.:.:||:|::.|||.||::.:|. |::.|.|.||:::
  Rat   413 LNPYFNESFSFEIPFEQ-----IQKVQVVVTVLDYDKLGKNEAIGKIFVGS-NATGTELRHWSDM 471

  Fly   459 CNSPRRQIAEWHKL 472
            ..:|||.||:||.|
  Rat   472 LANPRRPIAQWHSL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	50/153 (33%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	69/141 (49%)
Syt2	XP_038946276.1	Syt2_N	81..193	CDD:409249	17/127 (13%)
		C2A_Synaptotagmin-1-5-6-9-10	219..341	CDD:176031	49/139 (35%)
		C2B_Synaptotagmin-1	351..486	CDD:176047	70/148 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820