Protein Alignment Syt4 and Sytl5

DIOPT Version :9

• Sequence 1: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_808372.1
• Gene: Sytl5 / 236643
• MGIID: 2668451
• Length: 753
• Species: Mus musculus
• Alignment Length: 527
• Identity: 124/527 - (23%)
• Similarity: 199/527 - (37%)
• Gaps: 127/527 - (24%)

  Fly     6 IPDASVMDTIVPAILGLTAAAVLSSVACICAR--QMRLRN-----------------KKQSQHDA 51
            :|.|..:.:|.....|...:..|:::...|..  :...||                 :.:|:.|.
Mouse   265 VPSAHSVTSINSREHGFENSMALATIENTCEELTKSHRRNTSGTPSIAVSGTSLSSERSRSEVDL 329

  Fly    52 SFPFQPTRRPT-AVRSPSGQPPHYLKKSPSPTGGKQMG--LLSPMQDQSTSPIAQPNVKYSEEGD 113
            |..|......| ::||.|  .|..|.|..:.....:.|  |:|.....:|..:|......|:.|
Mouse   330 SESFAEDLEDTSSIRSRS--VPGALDKDLNSLEDTEDGVDLVSSRFSANTHSLASGLSTNSQAG- 391

  Fly   114 GPAQHAEQQNGNQLTVVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYG 178
                  ..:..:.|.|.|.:....|| ||:.....||...|:|.:|
Mouse   392 ------SDRKRSYLNVPDADSDTTSL-NSMMSVYSETGDYGNVKVT------------------- 430

  Fly   179 KLGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDK- 242
              |.|...:.|..:...|.:.:..||.|       .|||       ..:..||.|||..|||||
Mouse   431 --GEILLHISYCYKTGGLYIFVKSCRNL-------ATGD-------EKKQRTDAYVKSYLLPDKS 479

  Fly   243 -QHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEI 306
             .:|.||: :|...||.::|... |.::...|:..:|...:..:||:.|:..:|||.....|...
Mouse   480 RNNKRKTK-IRTGTNPEFNETLK-YTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIAFDSWNF 542

  Fly   307 GDISKE--ALSISKEIQPRSLKIRAQGRGELLISLCWQP-------------------------- 343
            .:...|  .|....|:.|   .|..|.:|||.|.|.:.|
Mouse   543 ENPCDEWFVLQPKVELAP---DISLQYKGELTIVLRYIPPEENLIFPAGQRQEKKIFKRGKKKES 604

  Fly   344 ---AAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFD 405
               :.|.|.|.:.||:||..:...|.:|.:||.|||.:..:..|.||.|.|::::|.:|.:|.|
Mouse   605 SSISGGILEVFIKKAKNLTAVKSGGTSDSFVKGYLLPDDNKATKHKTAVVKKSVNPEWNHTFIF- 668

  Fly   406 IPAAEGAG---ASLEGVSLELMLLDWDRVTKNEVIG--RLELGGPNSSSTAL----NH------W 455
                  :|   ..::...|||.:.|.:..:.|..:|  ||..|...|....:    :|      |
Mouse   669 ------SGLYPQDIKNACLELTIWDKEAFSSNVFLGGVRLNSGSGMSYGKTVDWMDSHGEEQRLW 727

  Fly   456 NEVCNSP 462
            .::.::|
Mouse   728 QKMADNP 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	40/146 (27%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	43/175 (25%)
Sytl5	NP_808372.1	PHD_SF	11..123	CDD:419867
		FYVE_Slp5	62..108	CDD:277305
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..279		3/13 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	297..359		13/63 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..404		5/30 (17%)
		C2A_SLP-4_5	430..553	CDD:175995	39/159 (25%)
		C2B_SLP_1-2-3-4	567..745	CDD:175987	43/175 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810