Protein Alignment Syt4 and Syt2

DIOPT Version :9

• Sequence 1: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001342655.1
• Gene: Syt2 / 20980
• MGIID: 99666
• Length: 422
• Species: Mus musculus
• Alignment Length: 452
• Identity: 144/452 - (31%)
• Similarity: 222/452 - (49%)
• Gaps: 104/452 - (23%)

  Fly    76 KKSPSPTGGKQMGLLSPMQDQSTSPIAQ-PNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSL 139
            |::..|.       ::|....:|.|:|. .....|.|..||.:..|.....         ||...
Mouse     6 KRNQEPN-------VAPATTTATMPLAPVAPADNSTESTGPGESQEDMFAK---------LKEKF 54

  Fly   140 HNSLHHSPVE-------TIANGSVTITL------------------------------------D 161
            .|.::..|:.       .:..|.:.:|.                                    |
Mouse    55 FNEINKIPLPPWALIAMAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQD 119

  Fly   162 DHSLTNGKELTVTDQYGK-------LGTIYFKLRYLAERNALMVSIIRCRGLPC--KGGSSGTGD 217
            |.....|  ||..:..|:       ||.:.|.|.|..:.|.|.|.:::...||.  .||:|
Mouse   120 DDDAETG--LTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTS---- 178

  Fly   218 IPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVI 282
                         |||||:.|||||:.|.:|:|.|.|.||.::|.||| .:...:|...:|...|
Mouse   179 -------------DPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTF-KVPYQELGGKTLVMAI 229

  Fly   283 LSFDRYSRDDVIGEVVCPLTSIEIGDISKE--ALSISKEIQPRSLKIRAQGRGELLISLCWQPAA 345
            ..|||:|:.|:||||..|:.::::|...:|  .|...::.:|..|       |::..||.:.|.|
Mouse   230 YDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKL-------GDICTSLRYVPTA 287

  Fly   346 GRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAE 410
            |:|||.:|:|:||.:|||.||:||||||:|:.||:|:.||||.|||:||:|.|||||:|:||..:
Mouse   288 GKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQ 352

  Fly   411 GAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHKL 472
                 ::.|.:.:.:||:|::.|||.||::.:|. |::.|.|.||:::..:|||.||:||.|
Mouse   353 -----IQKVQVVVTVLDYDKLGKNEAIGKIFVGS-NATGTELRHWSDMLANPRRPIAQWHSL 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	50/153 (33%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	69/141 (49%)
Syt2	NP_001342655.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43		10/43 (23%)
		Syt2_N	4..116	CDD:409249	17/125 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..141		6/40 (15%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		108/276 (39%)
		C2A_Synaptotagmin-1-5-6-9-10	142..264	CDD:176031	49/139 (35%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	70/148 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810