DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and Syt1

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001239270.1	Gene:	Syt1 / 20979	MGIID:	99667	Length:	421	Species:	Mus musculus

Alignment Length:	456	Identity:	149/456 - (32%)
Similarity:	233/456 - (51%)	Gaps:	97/456 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 RPTAVRSP----SGQPPHYLKKSPSPTGGKQ----------MGLLS--PMQDQSTSPIA------ 102
            ||.|:.:|    :...||...:..||..||:          |..|.  |:...:...||
Mouse     6 RPEALAAPVTTVATLVPHNATEPASPGEGKEDAFSKLKQKFMNELHKIPLPPWALIAIAIVAVLL 70

  Fly   103 ---------------QPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSLHN-SLHHSPVETI 151
                           :.|.|..:|..|.         |.:.:.|...|..::.: :|.....||
Mouse    71 VVTCCFCVCKKCLFKKKNKKKGKEKGGK---------NAINMKDVKDLGKTMKDQALKDDDAET- 125

  Fly   152 ANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPC--KGGSSG 214
                        .||:|:|.....:..|||.:.:.|.|..:.|.|:|.||:...||.  .||:|
Mouse   126 ------------GLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTS- 177

  Fly   215 TGDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLH 279
                            |||||:.|||||:.|.:|:|.|.|.|||::|.||| .:..::|...:|.
Mouse   178 ----------------DPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTF-KVPYSELGGKTLV 225

  Fly   280 FVILSFDRYSRDDVIGEVVCPLTSIEIGDISKE---ALSISKEIQPRSLKIRAQGRGELLISLCW 341
            ..:..|||:|:.|:|||...|:.:::.|.:::|   ..|..||.|.:        .|::..||.:
Mouse   226 MAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEK--------LGDICFSLRY 282

  Fly   342 QPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDI 406
            .|.||:||||:|:|:||.:|||.||:||||||:|:.||:|:.||||.:||.||:|.:||||:|::
Mouse   283 VPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEV 347

  Fly   407 PAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHK 471
            |..:     ::.|.:.:.:||:|::.||:.||::.: |.||:...|.||:::..:|||.||:||.
Mouse   348 PFEQ-----IQKVQVVVTVLDYDKIGKNDAIGKVFV-GYNSTGAELRHWSDMLANPRRPIAQWHT 406

  Fly   472 L 472
            |
Mouse   407 L 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	53/147 (36%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	66/141 (47%)
Syt1	NP_001239270.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..141		7/41 (17%)
		Phospholipid binding. /evidence=ECO:0000305	135..381		107/277 (39%)
		C2A_Synaptotagmin-1-5-6-9-10	142..264	CDD:176031	49/139 (35%)
		C2B_Synaptotagmin-1	273..408	CDD:176047	66/141 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820