DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and Syt17

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_620204.1	Gene:	Syt17 / 192189	RGDID:	708576	Length:	474	Species:	Rattus norvegicus

Alignment Length:	325	Identity:	109/325 - (33%)
Similarity:	177/325 - (54%)	Gaps:	37/325 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 SVTITLDD-HSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDI 218
            |:...||| .|||:.:   :..:| :||.::|..:|....|.|.|.:|..|.||          .
  Rat   163 SLDSNLDDVDSLTDEE---IMSKY-QLGMLHFSTQYDLLHNHLTVRVIEARDLP----------P 213

  Fly   219 PTGMNGRTQ--AATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFV 281
            |...:|..|  |.::||||:.||||:::..:|.|.|.|:.||::|.:|| .:...:.|..:|...
  Rat   214 PISHDGSRQDMAHSNPYVKICLLPDQKNSKQTGVKRKTQKPVFEERYTF-EIPFLEAQRRTLLLT 277

  Fly   282 ILSFDRYSRDDVIGEVVCPLTSIEI--GDISKEAL--SISKEIQPRSLKIRAQGRGELLISLCWQ 342
            ::.||::||..|||:|..||..:::  |....:||  |...|::          .||||:||.:.
  Rat   278 VVDFDKFSRHCVIGKVAVPLCEVDLVKGGHWWKALIPSSQNEVE----------LGELLLSLNYL 332

  Fly   343 PAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIP 407
            |:||||.|.:::|:.|.:.||:..:||:|||.|::..:.:..|||...:.|:.|.:||||:|.:|
  Rat   333 PSAGRLNVDIIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFKVP 397

  Fly   408 AAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHKL 472
            ..|     ||..||...:...:..:.|:.|||:.:|..:|..:..|||..:.|:.|..:.:||.|
  Rat   398 QEE-----LENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSESNHWRRMLNTHRTAVEQWHSL 457

Fly 473 472
Rat 458 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	49/148 (33%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	52/141 (37%)
Syt17	NP_620204.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		C2A_Synaptotagmin-15-17	186..314	CDD:176036	46/138 (33%)
		C2B_Synaptotagmin-17	323..457	CDD:176055	51/138 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820