DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and Rph3a

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_598202.2	Gene:	Rph3a / 171039	RGDID:	620073	Length:	684	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	126/461 - (27%)
Similarity:	204/461 - (44%)	Gaps:	107/461 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 RPTAVRSPSGQPPHYLKKSPSPTGGKQMGLLSP----MQDQST-SPIAQPN-----VKYSEEGDG 114
            ||.....||..||..::  |.|.||.:   .:|    ..:||| :|.:.|.     ....||..|
  Rat   279 RPAPASMPSPAPPQPVQ--PGPPGGSR---AAPGPGRFPEQSTEAPPSDPGYPGAVAPAREERTG 338

  Fly   115 PAQHAEQQNGNQLTVVDGNGLKHSLHNSLHHS---------PVETIANGSVTITLDDHSLTNGKE 170
            |.                .|.:.:.|.:..:|         |.|           ::....|..:
  Rat   339 PT----------------GGFQAAPHTAGPYSQAAPARQPPPAE-----------EEEEEANSYD 376

  Fly   171 LTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVK 235
               :|:...||.:.|.|.|..:.:.|..:|||.:||.           |...||    ..|||||
  Rat   377 ---SDEATTLGALEFSLLYDQDNSNLQCTIIRAKGLK-----------PMDSNG----LADPYVK 423

  Fly   236 LQLLP--DKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVV 298
            |.|||  .|.:|::|:.:|||||||::|...::|:...|:|..:|...:...|::..::.|||..
  Rat   424 LHLLPGASKSNKLRTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETR 488

  Fly   299 CPLTSIEIGDISKEALSISKEIQPRSLKIRAQG------------------------RGELLISL 339
            ..|..::..  .::..:|..|   |.:.::..|                        ||::|:||
  Rat   489 FSLKKLKAN--QRKNFNICLE---RVIPMKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSL 548

  Fly   340 CWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAF 404
            .:....|.|.|.:::..:|..||..|.:||:||::|..:..:.||.||.:||:||:|.|||.|.:
  Rat   549 MYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFY 613

  Fly   405 DIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEW 469
            ||..::     |...||::.:.|:|....|:.||..:| |.::....|.||.|...:..::|..|
  Rat   614 DIKHSD-----LAKKSLDISVWDYDIGKSNDYIGGCQL-GISAKGERLKHWYECLKNKDKKIERW 672

  Fly   470 HKL-NE 474
            |:| ||
  Rat   673 HQLQNE 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	45/144 (31%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	50/141 (35%)
Rph3a	NP_598202.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		FYVE_RP3A	88..168	CDD:277301
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..377		26/132 (20%)
		PRK07764	<175..352	CDD:236090	22/93 (24%)
		C2A_Rabphilin_Doc2	383..506	CDD:176000	44/139 (32%)
		C2B_Rabphilin_Doc2	543..675	CDD:176030	47/137 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910