DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and Sytl4

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_536335.1	Gene:	Sytl4 / 140594	RGDID:	620204	Length:	672	Species:	Rattus norvegicus

Alignment Length:	443	Identity:	110/443 - (24%)
Similarity:	187/443 - (42%)	Gaps:	98/443 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 QPPHYLKK----SPSPTGGKQMGLLSPMQDQSTS-PIAQPNVKYSEEGDGPAQH----------- 118
            :|..|.|.    .|... .::.|:|.   |:|.| |....:::..||.:....|
  Rat   267 RPSEYTKSVIDLRPEDV-AQESGILG---DRSKSVPGLSVDMEDEEEEEEDIDHLVKLHRQKLAR 327

  Fly   119 AEQQNGNQLTVVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTI 183
            ...|:|:.::.:   |...||::       |....|:|::|                     |.|
  Rat   328 GSMQSGSSMSTI---GSMMSLYS-------EAGDFGNVSVT---------------------GKI 361

  Fly   184 YFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDK--QHKV 246
            .|.|::..:...|::.:..|..|              ......:..::||||..|||||  |.|.
  Rat   362 AFSLKFEQKTQTLVIHVKECHQL--------------AYADEAKKRSNPYVKTYLLPDKSRQGKR 412

  Fly   247 KTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISK 311
            ||.:.|:|.||:|||.|. |.::.:.|...:|.|.:....|:.|:..:||....:.|.::.....
  Rat   413 KTSIKRDTINPLYDETFR-YEISESLLAQRTLQFSVWHHGRFGRNTFLGEAEVHMDSWKLDKKLD 476

  Fly   312 EALSISKEIQPRSLKIRAQGRGELLISLCWQPAA----------------GRLTVVLLKARNLPR 360
            ..|.:..:|...|.......:|||::||.:.||:                |.|.|.:.:|:||..
  Rat   477 HCLPLHGKISTESSPGLPAHKGELVVSLKYIPASKLPVGGDRKKSKGGEGGELQVWIKEAKNLTA 541

  Fly   361 MDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVS---LE 422
            ....|.:|.:||.|||....:.:|:||.|.|:||:|.:|.:|.::       |..||.:.   ||
  Rat   542 AKSGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYN-------GVRLEDLQHMCLE 599

  Fly   423 LMLLDWDRVTKNEVIGRLELG-GPNSSSTALNHWNEVCNSPRRQIAEWHKLNE 474
            |.:.|.:.:..|:.:|.:.|| |...||..:..|   .:|...:::.|.|:.:
  Rat   600 LTVWDREPLASNDFLGGVRLGVGTGISSGEVVDW---MDSTGEEVSLWQKMRQ 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	39/144 (27%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	48/160 (30%)
Sytl4	NP_536335.1	FYVE_Slp4	58..107	CDD:277303
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..222
		C2A_SLP-4_5	358..482	CDD:175995	39/159 (25%)
		C2B_SLP_1-2-3-4	497..662	CDD:175987	48/163 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810