Protein Alignment Syt4 and Doc2b

DIOPT Version :10

• Sequence 1: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_031899.2
• Gene: Doc2b / 13447
• MGIID: 1100497
• Length: 412
• Species: Mus musculus
• Alignment Length: 431
• Identity: 125/431 - (29%)
• Similarity: 196/431 - (45%)
• Gaps: 62/431 - (14%)

  Fly    54 PFQPTRRPTAV--RSPSGQPPHYLKKSPSPTGGKQMGLLSPMQDQSTSPIAQPNVKYSEEGDGPA 116
            |.:|.::.:..  |.|.|.||....::|:|               ..:|...|....|.......
Mouse    26 PIRPIKQISDYFPRFPRGLPPTAAPRAPAP---------------PDAPARSPAASASPRSPSDG 75

  Fly   117 QHAEQQNGNQLTVVDGNGLKHSLHNSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKLG 181
            ...:.::.:||....|    .|...|...||....|...     :|....:|.|   :|....||
Mouse    76 ARDDDEDVDQLFGAYG----ASPGPSPGPSPARPPAKPP-----EDEPDVDGYE---SDDCTALG 128

  Fly   182 TIYFKLRYLAERNALMVSIIRCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLP--DKQH 244
            |:.|.|.|..|.|||..:|.:.:||.           |...||    ..||||||.|||  .|.:
Mouse   129 TLDFSLLYDQENNALHCTISKAKGLK-----------PMDHNG----LADPYVKLHLLPGASKAN 178

  Fly   245 KVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDI 309
            |::|:.:|||.||.::|..|:||:...|:...:|...:...|::..::.|||...||..::....
Mouse   179 KLRTKTLRNTLNPSWNETLTYYGITDEDMVRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHT 243

  Fly   310 SKEALSISKEI-----QPRSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADP 369
            ...::.:.|::     :.:||    :.||.:||||.:......|.|.:::..:|..||..|.:||
Mouse   244 KTFSICLEKQLPVDKAEDKSL----EERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDP 304

  Fly   370 YVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKN 434
            |||.||..:..:.:|.||.|||:||:|.|||.|.::|...:     |...:||:.:.|:|....|
Mouse   305 YVKTYLKPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGD-----LAKKTLEVTVWDYDIGKSN 364

  Fly   435 EVIGRLELGGPNSSSTALNHWNEVCNSPRRQIAEWHKL-NE 474
            :.||.:.| |.|:....|.||.:...:..::|..||.| ||
Mouse   365 DFIGGVVL-GINAKGERLKHWFDCLKNKDKRIERWHTLTNE 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	46/149 (31%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	51/141 (36%)
Doc2b	NP_031899.2	Mediates interaction with DYNLT1. /evidence=ECO:0000250	1..90		14/78 (18%)
		Negatively regulates targeting to plasma membrane	1..36		2/9 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..123		21/111 (19%)
		C2A_Rabphilin_Doc2	127..250	CDD:176000	45/137 (33%)
		Mediates interaction with STXBP3. /evidence=ECO:0000269|PubMed:17548353	257..375		45/127 (35%)
		C2B_Rabphilin_Doc2	269..401	CDD:176030	48/137 (35%)