DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and PLA2G4E

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001193599.1	Gene:	PLA2G4E / 123745	HGNCID:	24791	Length:	868	Species:	Homo sapiens

Alignment Length:	177	Identity:	42/177 - (23%)
Similarity:	72/177 - (40%)	Gaps:	33/177 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 TDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVI 294
            ||.:|.|.|....|.|::||.:.|..||.::|.|.|.  ..:.::|: |...:...|..:.||.:
Human    89 TDCFVSLWLPTASQKKLRTRTISNCPNPEWNESFNFQ--IQSRVKNV-LELSVCDEDTVTPDDHL 150

  Fly   295 GEVVCPLTSIEIGDISKEALSISKEIQPRSLKIRAQGRGELLISLCWQ----PAAGRLTVVLLKA 355
            ..|:..||.          |...|:...: ..:..||..||.:....:    |....:|..:|.:
Human   151 LTVLYDLTK----------LCFRKKTHVK-FPLNPQGMEELEVEFLLEESPSPPETLVTNGVLVS 204

  Fly   356 RNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESF 402
            |.:..::|              :.|...::|.. |.:.|..:.||||
Human   205 RQVSCLEV--------------HAQSRRRRKRE-KMKDLLVMVNESF 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	25/91 (27%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	15/75 (20%)
PLA2G4E	NP_001193599.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		C2_cPLA2	69..177	CDD:176001	26/101 (26%)
		cPLA2_Grp-IVB-IVD-IVE-IVF	320..863	CDD:132840
		Required for localization at membrane structures. /evidence=ECO:0000269\|PubMed:30517655	857..868
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900