Protein Alignment Syt4 and TC2N

DIOPT Version :9

• Sequence 1: NP_477464.1
• Gene: Syt4 / 40876
• FlyBaseID: FBgn0028400
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001122067.2
• Gene: TC2N / 123036
• HGNCID: 19859
• Length: 490
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 104/477 - (21%)
• Similarity: 186/477 - (38%)
• Gaps: 92/477 - (19%)

  Fly    57 PTRRPTAVRSPSGQPPHYLKKSPSPTGGKQMGLLSPMQDQS-TSPIAQPNVKYSEEGDGPAQHAE 120
            |.....:|:...|....|| .|..|:.||::..:.|....| ..|..|....:.||.:|.|:.:.
Human    44 PPLTSVSVKPQLGCTEDYL-LSKLPSDGKEVPFVVPKFKLSYIQPRTQETPSHLEELEGSARASF 107

  Fly   121 QQNGNQLTVVDGNGLKHSLHNSL----HHSP-----------VETIAN-----------GSVTIT 159
            .....:|:....:|..:.::|..    |.||           |:.:..           ||..::
Human   108 GDRKVELSSSSQHGPSYDVYNPFYMYQHISPDLSRRFPPRSEVKRLYGSVCDLRTNKLPGSPGLS 172

  Fly   160 LDDHSLTNGKE-------------------------------LTVTDQYGKLGTIYFKLRYLAER 193
            .....|||..:                               :|::......|.:..||.|.:..
Human   173 KSMFDLTNSSQRFIQRHDSLSSVPSSSSSRKNSQGSNRSLDTITLSGDERDFGRLNVKLFYNSSV 237

  Fly   194 NALMVSIIRCRGLPCKGGSSGTGDIPT-GMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNP 257
            ..:.:::::||.|   ...|..||.|| .:.|           :..||...| .|:.....:...
Human   238 EQIWITVLQCRDL---SWPSSYGDTPTVSIKG-----------ILTLPKPVH-FKSSAKEGSNAI 287

  Fly   258 VYDEDFTFYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQP 322
            .:.|.|.| .:.:.:||.:.|.|.|.:  :..|...|||  |   |:.:..:|.:.:..|.:|.|
Human   288 EFMETFVF-AIKLQNLQTVRLVFKIQT--QTPRKKTIGE--C---SMSLRTLSTQEMDYSLDITP 344

  Fly   323 RSLKIRAQGRGELLISLCWQPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKT 387
            .| || :....||.:..|:|....|:.:.:|:||.||..........:||:.:..:|:.|.||||
Human   345 PS-KI-SVCHAELELGTCFQAVNSRIQLQILEARYLPSSSTPLTLSFFVKVGMFSSGELIYKKKT 407

  Fly   388 HVKKRTLSPV-FNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELGGPNSSSTA 451
            .:.|.:...| :.|:..|.:..:|      :.:...:.|.....|.:...:|::.:...:::..|
Human   408 RLLKASNGRVKWGETMIFPLIQSE------KEIVFLIKLYSRSSVRRKHFVGQIWISEDSNNIEA 466

  Fly   452 LNHWNEVCNSPRRQIAEWHKLN 473
            :|.|.|...:|.:.:..|||||
Human   467 VNQWKETVINPEKVVIRWHKLN 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	34/143 (24%)
		C2B_Synaptotagmin-4	332..473	CDD:176049	34/141 (24%)
TC2N	NP_001122067.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..215		0/25 (0%)
		C2A_Tac2-N	240..342	CDD:176066	29/124 (23%)
		C2B_Tac2-N	353..487	CDD:176074	33/139 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	447..449		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810