DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt4 and sytl4

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_031746962.1	Gene:	sytl4 / 100495134	XenbaseID:	XB-GENE-958567	Length:	692	Species:	Xenopus tropicalis

Alignment Length:	477	Identity:	115/477 - (24%)
Similarity:	200/477 - (41%)	Gaps:	99/477 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 MRLRNKKQS-----------------QHDASFPFQPTRRPTAVRSPSGQPPHYLKKSPSPTGGKQ 86
            :|.|::.||                 :.|..|...|.|    :..|:......|...|.|...::
Frog   254 VRSRDRHQSDSEGEALLGSRSAGSADESDTLFKKNPRR----LLKPADYSKSVLDLRPEPAAPEE 314

  Fly    87 MGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSLHNSLHHSPVETI 151
                :.:.|:|.| :.:.|::..||.:                        .:.|.:.   :..:
Frog   315 ----NALGDRSKS-VPRLNIEMEEEDE------------------------DIDNLVE---IHRL 347

  Fly   152 ANGSVTITLDDHSLTNGKELTVTDQYGKLGT------IYFKLRYLAERNALMVSIIRCRGLPCKG 210
            :.|..::.....|.|.|..:::..:.|..|.      |.|.:.|.|:...|.:.:..||.|
Frog   348 SAGRSSLRSGASSSTLGSMISIYSEAGDFGNVIITGEIIFSINYDAKVQLLNILVKECRNL---- 408

  Fly   211 GSSGTGDIPTGMNGRTQAATDPYVKLQLLPDK--QHKVKTRVVRNTRNPVYDEDFTFYGLNMNDL 273
               ..||       ..:..::||:|..|||||  |.|.||.:.|||.||:|:|... |.:..:.|
Frog   409 ---AYGD-------ELKMRSNPYIKSYLLPDKSRQGKRKTTIKRNTTNPMYNEVLK-YIVPESML 462

  Fly   274 QNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQPRSLKIRAQGRGELLIS 338
            ...||...:..:||:.|:..:|:|..||.|.....:.:|.|.:..:....|.......:|||::|
Frog   463 HLRSLELSVWHYDRFGRNTFLGQVDIPLDSWNFDSLIEECLPLHGKGNMDSGAGFYNSKGELVVS 527

  Fly   339 LCWQP---------------AAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTH 388
            |.:.|               ..|.|.|.:.:|:||..:...|::|.:||.||..:..:..|:||.
Frog   528 LKYVPPTKPSGSERRKKKADEGGELHVWIKEAKNLTAVKTGGISDSFVKGYLFPHKNKNTKRKTP 592

  Fly   389 VKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELG-GPNSSSTAL 452
            |.|:||:|.:|.:|.::....|    .|:.|.|||.:.|.:.::.|:.:|.:.|| |...|:..|
Frog   593 VVKKTLNPHYNHTFVYNGIKPE----DLQNVCLELTVWDREPLSSNDFLGGVRLGIGNGMSNGEL 653

  Fly   453 NHWNEVCNSPRRQIAEWHKLNE 474
            ..|   .:|...:::.|.|:.:
Frog   654 VDW---MDSTGEELSLWQKMRQ 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	44/150 (29%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	46/156 (29%)
sytl4	XP_031746962.1	PHD_SF	15..126	CDD:419867
		FYVE_Slp4	63..112	CDD:277303
		C2A_SLP-4_5	382..506	CDD:175995	43/138 (31%)
		C2B_SLP_1-2-3-4	521..685	CDD:175987	46/159 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910