DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and syt13

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_031756290.1	Gene:	syt13 / 100494466	-ID:	-	Length:	450	Species:	Xenopus tropicalis

Alignment Length:	467	Identity:	122/467 - (26%)
Similarity:	190/467 - (40%)	Gaps:	111/467 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ICAR-QMRLRNKKQSQHDASFPFQPTRRP--------TAVRSPSGQ---PPHYLKKSPSPT-GGK 85
            |||| ....||       .:.|....|.|        |.:..|..:   |..|..|.|.|| ||.
Frog    67 ICARLAWHSRN-------LASPIGTDRLPEQMSIYKCTELVHPQAKLRFPYIYRSKEPCPTLGGD 124

  Fly    86 QMGLLSPMQDQSTSPIAQPNVKYSEEGDGPAQH-AEQQNG--NQLTVVDGNGLKHSLHNSLHHSP 147
            :         :.||...:.......|..|..:. :|:.|.  |:.::...|..:.....||:|.|
Frog   125 K---------EETSKENKDEKSGETEPQGKVETISEKINSEKNEESLAPENEYEEKFSQSLNHIP 180

  Fly   148 VETIANGSVTITLDDHSLTNGKELTVTDQYGKLGTIYFKLRYLAERNALMVSIIRCRGLP-CKGG 211
                                              .:.:.|.|..::..|.||.:...|.| .|..
Frog   181 ----------------------------------KLRYSLGYDHQKRELCVSFLEAVGCPLTKEE 211

  Fly   212 SSGT-----GDIPTGMNGRTQAATDPYVKLQLLPDKQHKVKTRVVRNTRNPVYDEDFTFYGLNMN 271
            .||:     |.: |...|:|:|                  :|.::..|.:.|:||...| .|:..
Frog   212 DSGSHSYIVGTL-TSNGGQTEA------------------QTSLMNRTPHTVWDEALLF-PLSEE 256

  Fly   272 DLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQPRSLKIRAQGRGELL 336
            :.....|...:...|||||..|.||:...|.::.:      ....::.:..|..:...:|.||:|
Frog   257 ERVEAELTLTLRHCDRYSRHQVAGEITLSLANLGV------PFGAARWVDLRPPEKELEGSGEVL 315

  Fly   337 ISLCWQPAAGRLTVVLLKARNLPRMDVTGL--ADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFN 399
            :||.:.|||.||.||::||||:.......|  .|..:|:.|.:..|::.||:|...|..::||:|
Frog   316 LSLSYLPAASRLIVVVIKARNIHCDQYNNLLGKDLSIKVILKHQSQKLKKKQTKRTKHMINPVWN 380

  Fly   400 ESFAFDIPAAEGAGASLEG---VSLELMLLDWDRVTKNEVIGRLELGGPNSSSTALNHWNEVCNS 461
            |...|::|      ..|.|   |.|:::.:..|| :.|.::|...||. ..:.|..|||.|:.|:
Frog   381 EMVMFEVP------QELLGDVYVELQMVCVKPDR-SGNHILGTCNLGA-EWTGTGKNHWLEMMNN 437

  Fly   462 PRRQIAEWHKLN 473
            ||||||.||:||
Frog   438 PRRQIAFWHRLN 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	32/148 (22%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	55/145 (38%)
syt13	XP_031756290.1	PHA02644	<126..175	CDD:165026	8/48 (17%)
		C2	180..301	CDD:417471	33/180 (18%)
		C2	311..448	CDD:417471	55/144 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X61
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020