DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt4 and LOC100486361

DIOPT Version :9

Sequence 1:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_002931826.4	Gene:	LOC100486361 / 100486361	-ID:	-	Length:	959	Species:	Xenopus tropicalis

Alignment Length:	553	Identity:	122/553 - (22%)
Similarity:	207/553 - (37%)	Gaps:	175/553 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RNKKQSQHDASFPFQPTRRPTAVR--------SPSGQPPHYLKKSPSPTGGKQMGLLSPMQDQST 98
            |:.|:|:       .|.|.|:..:        ||..:.|:.          .|:...| .:::|.
Frog   440 RSSKRSK-------LPVRLPSVSKETKVDVPLSPRDKLPNV----------SQLETAS-CKEESV 486

  Fly    99 SPIAQPNVK---YS-------------EEG-----------DGPAQHA--EQQNGNQLTVVDGN- 133
            :|..:|.||   ||             |:|           :...:||  |.::|..|   |||
Frog   487 TPEIKPEVKGTPYSNVQILIDTVTSDEEQGATASVKAAQRSEDVVEHATCESEDGKSL---DGNV 548

  Fly   134 ---------GL--KHSLHN------------SLHH-------------------SPVETIANGSV 156
                     |:  ..||.|            :|.|                   |..|:.....:
Frog   549 DSNPTSQAIGVTSARSLVNIYTSTETYNKPQTLSHQLLEPERAKELSRSTPALLSETESDTASEI 613

  Fly   157 TITLDDHSLTNGKELTVTD-----------------QYGKL---GTIYFKLRYLAERNALMVSII 201
            :..|..|..|:..:...:|                 .:|.:   |.:.|.|.|..:.....:|:.
Frog   614 SFQLKRHRKTHSSDSNSSDMASVSSVSNSVLSVYSGDFGSVDAQGAVEFSLDYDEKNREFQISVS 678

  Fly   202 RCRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQH--KVKTRVVRNTRNPVYDEDFT 264
            :|:.|.          |.....||    :|||||..|||||..  |.||.|.|.|.||||:|...
Frog   679 QCKDLA----------IVDEKKGR----SDPYVKTYLLPDKARMGKRKTSVKRRTTNPVYNEVLR 729

  Fly   265 FYGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEIGDISKEALSISKEIQPRSLKIR- 328
             |.:....|....|:..:...|...|:..:||:...|||.:..:..    |....::|||:...
Frog   730 -YKIEKMVLLIQKLNLSVWHNDPLGRNSFLGEMEIDLTSWDWSNTK----SNWYPLKPRSVSAMN 789

  Fly   329 -AQGRGELLISLCW---------QPAAGRLTVVLLKARNLPRMDVTGLADPYVKIYLLYNGQRIA 383
             ....|.:.:|:.:         .|.:|.:.:.:...::||::..:|: |.:||.|:|.:..:.:
Frog   790 GVDHLGVMNLSIKYIPPGSLGPKHPTSGEVHIWVKDTKDLPQLRPSGV-DSFVKCYVLPDTSKKS 853

  Fly   384 KKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLEGVSLELMLLDWDRVTKNEVIGRLELG----- 443
            .:||.|.|:..:||||.:..:|....|    .|....:||.:.|.:::: |..:|.:.||
Frog   854 YQKTRVIKKDSNPVFNHTIVYDGFHTE----DLRDACVELTVWDHEKLS-NHFLGGIRLGLGTGF 913

  Fly   444 -------GPNSSSTALNHWNEVCNSPRRQIAEW 469
                   ..:|:...:..|.|:.::|.    ||
Frog   914 SYGIAVDWMDSTQEEVAFWQEMMSTPN----EW 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	42/147 (29%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	36/159 (23%)
LOC100486361	XP_002931826.4	PHD_SF	13..>68	CDD:419867
		C2A_SLP-1_2	657..781	CDD:176039	42/142 (30%)
		C2B_SLP_1-2-3-4	795..950	CDD:175987	36/158 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910