DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gld and HTH

DIOPT Version :9

Sequence 1:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_565050.1	Gene:	HTH / 843628	AraportID:	AT1G72970	Length:	594	Species:	Arabidopsis thaliana

Alignment Length:	637	Identity:	158/637 - (24%)
Similarity:	249/637 - (39%)	Gaps:	176/637 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 ASSRFRSE-PDYEYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAGGDEPVGAQIPSMFLNF-IG 115
            :||.|.|. .|..||:||||||:||..:|:.||:  .:.||::|.||.....|.: |...|| ||
plant    50 SSSSFSSNGQDSSYDYIVIGGGTAGCPLAATLSQ--NFSVLVLERGGVPFTNANV-SFLRNFHIG 111

  Fly   116 -SDIDYRYNTEPEPMACLSSMEQRCYWPRGKVLGGTSVLNGMMYVRGN-----REDYDDWAADGN 174
             :||    :......|.:|:  ...|..|.:||||.|.:|...|.|.:     |..:|......:
plant   112 LADI----SASSASQAFVST--DGVYNARARVLGGGSCINAGFYSRADAAFVKRAGWDPKLVKES 170

  Fly   175 PGWAYNDV-----LPFFKKSEDNLDLDEVGTEYHAKGGLLPVGKFPYNPPLSYAILKAGEELGFS 234
            ..|...::     |..::|:              .:..||.||..|:|              ||:
plant   171 YPWVEREIVHQPKLTLWQKA--------------LRDSLLEVGVRPFN--------------GFT 207

  Fly   235 VHDLNGQNSTGFMIAQMTARNGIRYSSAR--AFLRPARMRNNLHILLNTTATKILIHPH--TKNV 295
            ...::|....|.:.    .|.|.|:::|.  |:..|.::|    :|:..|..||:....  ...|
plant   208 YDHVSGTKIGGTIF----DRFGRRHTAAELLAYANPQKLR----VLIYATVQKIVFDTSGTRPRV 264

  Fly   296 LGVEVSDQFGSTRKILVK----KEVVLSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGK 356
            .||...|:.|:..:.|:.    .||:||:||:.||.:|:|||:|||.|||::.:..|.....|||
plant   265 TGVIFKDEKGNQHQALLSNRKGSEVILSSGAIGSPQMLMLSGIGPKKELQRLKIPVVLENEHVGK 329

  Fly   357 NLHNHVTYFTNFFIDDADTAPLNWATAMEYLLFRDGLMSGTGIS--DVTAKLATRYADSPERPDL 419
            .:              ||. |:|.............|:...||:  .|..:.:|.:..|||  .:
plant   330 GM--------------ADN-PMNTILVPSKAPIEQSLIQTVGITKMGVYVEASTGFGQSPE--SI 377

  Fly   420 QLYFGGYLASCARTGQVGELLSNNSRSIQIFPA-------------------------------V 453
            ..::|              ::||.:......||                               :
plant   378 HTHYG--------------IMSNKNELFSTIPAKQRRPEATQAYITRNKYQLHEAFNGSFILEKL 428

  Fly   454 LNPRSRGFIGLRSADPLEPPRIVANYLTHEQDVKTLVEGIKFVIRLSQTTPLKQYGMRLDKTVVK 518
            ..|.|||.:.|.:.:..:.|.:..||..|..|::..||.|:.|.::..:.....| .:.||..|
plant   429 AYPISRGHLSLVNTNVDDNPSVTFNYFKHPVDLQRCVEAIRLVSKVVTSNRFLNY-TQCDKQNV- 491

  Fly   519 GCEAHAFGSDAYWECAVRQNTG--PEN-------------------HQAGSCKMGPSHDPMAVVN 562
                |...|     .:|:.|..  |:.                   |..|.|.:|      .||:
plant   492 ----HKMLS-----LSVKANINLRPKQLNDTKSMAQFCKDTVVTIWHYHGGCLVG------KVVS 541

  Fly   563 HELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKGAYLLKRAWGAKVXR 614
            ...:|.|:..|||:|.|...:....|..|..:|:   |.|:     |.|:.|
plant   542 PNRKVLGVDRLRVIDGSTFDESPGTNPQATMMMM---GRYM-----GVKILR 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	20/42 (48%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	148/610 (24%)
HTH	NP_565050.1	PLN02785	18..594	CDD:215420	158/637 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D798314at2759
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		mtm950
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.730