DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gld and CG6142

DIOPT Version :9

Sequence 1:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_651466.1	Gene:	CG6142 / 43178	FlyBaseID:	FBgn0039415	Length:	616	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	221/577 - (38%)
Similarity:	340/577 - (58%)	Gaps:	48/577 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 EYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAG------GDEPVGAQIPSMFLNFIGSDIDYRY 122
            |||||::|.||||.|:|:||||:....|||:|||      .|.|:.|.:..|      :..::.|
  Fly    47 EYDFIIVGAGSAGCVMANRLSEISSASVLLLEAGDQETFISDVPLTAALTQM------TRYNWGY 105

  Fly   123 NTEPEPMACLSSMEQRCYWPRGKVLGGTSVLNGMMYVRGNREDYDDWAADGNPGWAYNDVLPFFK 187
            ..||...||.......|.||:|:.:||||::|.|:|.||:|.|||:|||..|.||:|:::||:|:
  Fly   106 KAEPTEHACQGLKGGVCNWPKGRGVGGTSLINFMLYTRGHRRDYDEWAAANNSGWSYDELLPYFR 170

  Fly   188 KSEDNLDLDEV-GTEYHAKGGLLPVGKFPYNPPLSYAILKAGEELGFSVHDLNGQNSTGFMIAQM 251
            ||| .:.:.|: .:.||.:.|.|.|....|...|..|.||:|.|:|:.:.|.||::..||..:|.
  Fly   171 KSE-RIGIPELYKSPYHGRNGQLDVQYTDYRSQLLKAFLKSGREMGYEITDPNGEHLMGFARSQA 234

  Fly   252 TARNGIRYSSARAFLRPARMRNNLHILLNTTATKILIHPHTKNVLGVEVSDQFGSTRK---ILVK 313
            |.|||.|.|:::||::|...|.||||.:.:..|:::|.|.||...|||    |...|:   :..:
  Fly   235 TIRNGRRCSTSKAFIQPVVNRKNLHISMKSWVTRLIIDPITKTATGVE----FVKQRQRYVVRAR 295

  Fly   314 KEVVLSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHNHVTYFTN---FFIDDA-- 373
            |||:||||.:.||.:|:|||:||.:.|::.|:..:.:|| ||.||.:|:|  .|   |.::|:
  Fly   296 KEVILSAGTIASPQLLMLSGIGPAEHLREHNITVMQDLP-VGYNLQDHIT--LNGLVFVVNDSTV 357

  Fly   374 -DTAPLNWATAMEYLLFRDGLMSGTGISDVTAKLAT---RYADSPERPDLQLYFGGYLASCARTG 434
             |...||.:....|:....|..:..|.::..|.:.|   ::|  .:.||::|..|....|..|.|
  Fly   358 NDARLLNPSDIFRYIFAGQGPYTIPGGAEAFAFVRTPSSKFA--KDYPDMELVLGAGSLSGDRFG 420

  Fly   435 QVGELLS-------------NNSRSIQIFPAVLNPRSRGFIGLRSADPLEPPRIVANYLTHEQDV 486
            .:..||.             .:..:..:.|.:|.|:|||.|.|||.:|...||:..|::.|..||
  Fly   421 TMRNLLGITDEFYDYMFGDLQSKETFGLVPVLLRPKSRGRISLRSRNPFHWPRMEPNFMQHPDDV 485

  Fly   487 KTLVEGIKFVIRLSQTTPLKQYGMRLDKTVVKGCEAHAFGSDAYWECAVRQNTGPENHQAGSCKM 551
            :.::|||:.:::||::.|:.:.|.|.......|||...|.|:|||:|.:|:......||:|:|||
  Fly   486 RAMIEGIEMILKLSRSKPMAKMGTRFHDRPFPGCENLKFASEAYWKCCLRRYGSSLQHQSGTCKM 550

  Fly   552 GPSHDPMAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKGAYLLKRAW 608
            ||:.|..:||:.:||:||||||||:|.|::|.|.:|:|:|..:|:|||...::|.||
  Fly   551 GPATDNTSVVDAQLRIHGIRGLRVVDASVLPNVPAGHTNAIVIMVAEKAGDMIKDAW 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	19/30 (63%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	218/568 (38%)
CG6142	NP_651466.1	PRK02106	47..604	CDD:235000	218/572 (38%)
		NADB_Rossmann	48..342	CDD:304358	127/305 (42%)
		GMC_oxred_C	455..599	CDD:282984	64/143 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	9	8.970