DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gld and ninaG

DIOPT Version :9

Sequence 1:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_650070.1	Gene:	ninaG / 41369	FlyBaseID:	FBgn0037896	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	601	Identity:	160/601 - (26%)
Similarity:	276/601 - (45%)	Gaps:	109/601 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 EPDYEYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAGGDEPVGAQIPSMFLNFIGSDI-DYRYN 123
            |..:.:|::::|||:.||.:.|.|::.....||||||||...:.::|| :...|....| |:.:.
  Fly    42 ERHFAFDYVIVGGGTGGSTLTSLLAKNSNGSVLLIEAGGQFGLLSRIP-LLTTFQQKGINDWSFL 105

  Fly   124 TEPEPMACLSSMEQRCYWPRGKVLGGTSVLNGMMYVRGNREDYDDWAADGN-PGWAYNDVLPFFK 187
            :.|:..:....:|:|...||||.|||::.||.|::..|:..|:|.|....| ..|::..:..|..
  Fly   106 SVPQKHSSRGLIERRQCLPRGKGLGGSANLNYMLHFDGHGPDFDSWRDHHNLSDWSWAQMRSFMA 170

  Fly   188 KSE-DNLDLDEVGTEYHAKGGLLPVGKFPYNPPLSYAILKAGEELGF-------SVHDLNGQNST 244
            .:: .|.|:.|:...|               ..|:.|:.:|..:..:       |::::
  Fly   171 AAKPKNPDMLEIPRRY---------------SKLTEALEEAQAQFAYKDWIFRRSLYNI------ 214

  Fly   245 GFMIAQMTARNGIRYSSARAFLRPARMRNNLHILLNTTATKILIHPH-----TKNVLGVEVSDQF 304
                     |||:|:|..:.||.|....:||.:|.:....:|.:.|.     |..::|::..:..
  Fly   215 ---------RNGLRHSVVQQFLNPVIHHSNLRLLPDALVKRIQLAPSPFLQATSILVGIKDEENR 270

  Fly   305 GSTRKILVKKEVVLSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHNHVTYFTNFF 369
            .....|.|::|::|.|||..:|.:|:.||:|....|:::.:...|:||.||.|||:|  :....|
  Fly   271 EKEFSIEVRRELILCAGAYQTPQLLMASGIGDVSALKKLGIPAQHSLPLVGHNLHDH--FNLPLF 333

  Fly   370 IDDADTAP-LNWATAMEYLLFRDGLMSGTG-------ISDVTAKLATRYADSPERPDLQLYFGGY 426
            :....|.| ||..|.:..:...:.|.||:|       :.:|.:     |......|....:||
  Fly   334 VSMGVTGPTLNQNTLLNPMTLINYLSSGSGPLGNFGVLGNVVS-----YGGLGAPPYGITFFG-- 391

  Fly   427 LASCARTGQVGE--LLS-----------------NNSR-SIQIFPAVLNPRSRGFIGLRSADPLE 471
                  .|.:.|  |:|                 |:|: ...:..:.|.|:|||.:||.:.....
  Fly   392 ------AGAIDESALMSISNFKGPAFRALFPRYYNSSQEGFVVISSCLQPKSRGSVGLLNRHMRR 450

  Fly   472 PPRIVANYLTHEQDVKTLVEGIKFVIRLSQTTPLKQYGMRLDKTVVKGCEAHAFG---------- 526
            .|.|..|||:.|:||...:..|:..:.|..:|.......|:....|:.|.  .||
  Fly   451 NPLIDPNYLSSEEDVACTISAIRSAVELVNSTAFAALHPRIHWPRVQECS--NFGPFERDFFDNR 513

  Fly   527 -SDAYWECAVRQNTGPENHQAGSCKMGPSHDPMAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTH 590
             ||.|.||.:|......:|..|:|.:|      :||:.:||:.|:..:||:|.|::|:..|||.:
  Fly   514 PSDQYLECLMRHVGLGSHHPGGTCALG------SVVDSQLRLKGVSNVRVVDASVLPRPISGNPN 572

  Fly   591 APAVMIAEKGA-YLLK 605
            :..|.||.:.| ::||
  Fly   573 SVVVAIALRAASWILK 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	12/34 (35%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	156/590 (26%)
ninaG	NP_650070.1	BetA	72..588	CDD:225186	149/569 (26%)
		NADB_Rossmann	119..327	CDD:304358	62/237 (26%)
		GMC_oxred_C	435..582	CDD:282984	48/154 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I3423
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm47571
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	8	7.920