DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gld and CG9521

DIOPT Version :9

Sequence 1:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_572977.1	Gene:	CG9521 / 32414	FlyBaseID:	FBgn0030588	Length:	621	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	230/572 - (40%)
Similarity:	326/572 - (56%)	Gaps:	34/572 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DYEYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAGGDEPVGAQIP--SMFLNFIGSDIDYRYNT 124
            |.||||||:|.|:||..:|:||||.|||:|||:||||.|.:...:|  :.||..  .:::::|.|
  Fly    57 DSEYDFIVVGAGTAGCALAARLSENPQWRVLLLEAGGPERLVMDVPIVAHFLQL--GEMNWKYRT 119

  Fly   125 EPEPMACLSSMEQRCYWPRGKVLGGTSVLNGMMYVRGNREDYDDWAADGNPGWAYNDVLPFFKKS 189
            :|...|||:....||.||||||:||:||||.|||.||||.|||.|.|.|||||::.||||:|||.
  Fly   120 QPSDHACLAMNNNRCNWPRGKVMGGSSVLNYMMYTRGNRRDYDRWEALGNPGWSFKDVLPYFKKY 184

  Fly   190 EDNLDLDEVGTEYHAKGGLLPVGKFPYNPPLSYAILKAGEELGFSVHDLNGQNSTGFMIAQMTAR 254
            |.: .:.:...:|..:.|.:.|....:...::.|.:.|.::.|....|.||:...|......|.|
  Fly   185 EGS-SVPDAEEDYVGRNGPVKVSYVNWRSKIAEAFVDAAQQDGLKYRDYNGRIQNGVAFLHTTTR 248

  Fly   255 NGIRYSSARAFLRPAR-MRNNLHILLNTTATKILIHPHTKNVLGVEVSDQFGSTRKILVKKEVVL 318
            |..|:||.||:|.|.: .|:|||:..|...||:||.|.||...|:.|..: |..:|||.:|||::
  Fly   249 NSTRWSSNRAYLYPLKGKRSNLHVRKNALVTKVLIDPQTKTAYGIMVQTE-GRMQKILARKEVIV 312

  Fly   319 SAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHNH----VTYFTNF----FIDDADT 375
            ||||:|:|.:|:||||||...|::|.::.:.:| .||.||.:|    ||:.||.    |.|.:|.
  Fly   313 SAGAINTPQLLMLSGVGPAKHLREVGIKPLADL-AVGYNLQDHTAPAVTFTTNATSLKFEDFSDP 376

  Fly   376 APLNWATAMEYLLFRDGLMSGTGISDVTAKLATRYADSPERPDLQLYF-GGYLASCARTGQV--- 436
            ..:|....||......|........|:..:     .|....||::|:. ||.::|.....:.
  Fly   377 TLINRFNRMEGPYGSPGGCEAIAFWDLDHE-----RDEDGWPDIELFLVGGSMSSNPAISRAFGL 436

  Fly   437 ---------GELLSNNSRSIQIFPAVLNPRSRGFIGLRSADPLEPPRIVANYLTHEQDVKTLVEG 492
                     .|:...:..:..|||.:|.|:|||.|.|:|:||.:.|.|.|||..|..||...|.|
  Fly   437 KKSIYDTLFAEIEDKSLNAFMIFPMILRPKSRGRIMLKSSDPFKYPLIHANYFAHPYDVDISVRG 501

  Fly   493 IKFVIRLSQTTPLKQYGMRLDKTVVKGCEAHAFGSDAYWECAVRQNTGPENHQAGSCKMGPSHDP 557
            :...|.|.:...:::...||.:..:..|:.|.:.|.|||.|.||..|....|.:|:.||||..|.
  Fly   502 LLKAISLMEQRGMEKINARLWEKKIPTCKQHPYKSWAYWACYVRHFTFTIYHYSGTAKMGPKSDR 566

  Fly   558 MAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKGAYLLKRAWG 609
            .|||:|.||||||:.|||.|.||||::.||:.:.|..|||||.|.::|:..|
  Fly   567 AAVVDHRLRVHGIKNLRVADASIMPEIMSGHPNGPVFMIAEKAADMIKQDHG 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	22/32 (69%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	226/560 (40%)
CG9521	NP_572977.1	PRK02106	57..614	CDD:235000	228/566 (40%)
		NADB_Rossmann	61..>92	CDD:304358	20/30 (67%)
		NADB_Rossmann	125..356	CDD:304358	104/233 (45%)
		GMC_oxred_C	465..609	CDD:282984	65/143 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	10	9.870