DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gld and CG9522

DIOPT Version :9

Sequence 1:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_644677.1	Gene:	CG9522 / 32413	FlyBaseID:	FBgn0030587	Length:	616	Species:	Drosophila melanogaster

Alignment Length:	610	Identity:	235/610 - (38%)
Similarity:	342/610 - (56%)	Gaps:	35/610 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FMLFMGLLEVFIRSQCDLEDPCGRAS----SRFRSEPDYEYDFIVIGGGSAGSVVASRLSEVPQW 89
            |:|.:.|:.....||.|.....|..:    ..|...|...||||::|||:||..:|:||||.|.|
  Fly    11 FLLLIPLIHSQRSSQLDELRRLGLGNVVNVPFFSDVPQRNYDFIIVGGGAAGCTLAARLSENPNW 75

  Fly    90 KVLLIEAGGDEPVGAQIPSMFLNFIGSDIDYRYNTEPEPMACLSSMEQRCYWPRGKVLGGTSVLN 154
            .|.||||||.|.:..|:|.:..:...:..::.||:.|:..||....:.:|..||||||||||.:|
  Fly    76 SVFLIEAGGVENIVHQVPLLAAHLQSTASNWGYNSTPQRHACRGMPDNKCALPRGKVLGGTSSIN 140

  Fly   155 GMMYVRGNREDYDDWAADGNPGWAYNDVLPFFKKSEDNLDLDEVGTE---YHAKGGLLPVGKFPY 216
            .|:|.||||.|:|.|||.|||||:|::|||:|.:|| :..|.  |.|   ||...|.|.|....:
  Fly   141 YMIYNRGNRRDFDAWAAAGNPGWSYDEVLPYFLRSE-HAQLQ--GLEHSPYHNHSGPLSVEDVRH 202

  Fly   217 NPPLSYAILKAGEELGFSVHDLNGQNSTGFMIAQMTARNGIRYSSARAFLRPAR-MRNNLHILLN 280
            ...|::|.::|.:|.|....|.||::..|....|.|...|.|:|:.||::.|.| .|:|||||..
  Fly   203 RTRLAHAYIRAAQEAGHPRTDYNGESQLGVSYVQATTLKGRRHSAFRAYIEPIRSRRHNLHILTL 267

  Fly   281 TTATKILIHPHTKNVLGVEVSDQFGSTRKILVKKEVVLSAGAVNSPHILLLSGVGPKDELQQVNV 345
            ...|::||...||:..|||::.| |.:.|:..:||::|||||.|||.:|:|||:||:|.|:.:.:
  Fly   268 ARVTRVLIDAATKSAYGVELTHQ-GRSFKVKARKEIILSAGAFNSPQLLMLSGIGPEDNLKAIGI 331

  Fly   346 RTVHNLPGVGKNLHNHVTYFTNFFIDDAD-----TAPLNWATAMEYLLFR-DGLMSGTGISDVTA 404
            ..:..|| |||.:.:|:.:|...|:.:..     .|.|....|.|:||.| |..:|..|..:...
  Fly   332 PLIKALP-VGKRMFDHMCHFGPTFVTNTTGQTLFAAQLGAPVAKEFLLGRADTFLSSIGGVETLT 395

  Fly   405 KLATRYADSP-ERPDLQL-YFGGYLASCARTG---------QVGELLSNN--SRSIQIFPAVL-- 454
            .:......|| .:||::| ...|.|||...|.         ::.|.:..|  .|....|..::
  Fly   396 FIKVPSGKSPATQPDVELIQVAGSLASDDGTALAKGANFKPEIYEKMYKNLTLRQQDHFSFLIMH 460

  Fly   455 -NPRSRGFIGLRSADPLEPPRIVANYLTHEQDVKTLVEGIKFVIRLSQTTPLKQYGMRLDKTVVK 518
             .|.|.|.:.|.:.:|||.|||...|.:...||:.|:||||..:|:|:...::..|.||....|.
  Fly   461 FKPASVGRLWLHNRNPLEWPRIDPKYFSAPSDVENLLEGIKEALRISKMPAMQAIGTRLLDKPVP 525

  Fly   519 GCEAHAFGSDAYWECAVRQNTGPENHQAGSCKMGPSHDPMAVVNHELRVHGIRGLRVMDTSIMPK 583
            |||.:.|.||.||.|::|..:...:||..:|:||...||..||||:|:|||:|.|||:||||:|.
  Fly   526 GCENYEFASDDYWRCSIRTLSYTLHHQVATCRMGAESDPTTVVNHQLKVHGVRKLRVVDTSIIPF 590

  Fly   584 VSSGNTHAPAVMIAEKGAYLLKRAW 608
            ..:.:|:|.|.||.||.|.:::..|
  Fly   591 PPTAHTNAAAFMIGEKAADMIRSEW 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	27/69 (39%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	224/562 (40%)
CG9522	NP_644677.1	PRK02106	48..612	CDD:235000	225/568 (40%)
		NADB_Rossmann	52..>83	CDD:304358	19/30 (63%)
		NADB_Rossmann	127..348	CDD:304358	101/225 (45%)
		GMC_oxred_C	463..607	CDD:282984	64/143 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	9	8.960