DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gld and CG12539

DIOPT Version :9

Sequence 1:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_572976.1	Gene:	CG12539 / 32412	FlyBaseID:	FBgn0030586	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	217/574 - (37%)
Similarity:	320/574 - (55%)	Gaps:	38/574 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 YDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAGGDEPVGAQIPSMFLNFIGSDIDYRYNTEPEPM 129
            |||||||.|:||..:|:||||.||..|.||||||.|.:....|.:......:..::.|.:.|:.:
  Fly    58 YDFIVIGAGAAGCTLAARLSENPQVSVALIEAGGVENIAHLTPVVAGYLQQTSSNWGYKSVPQKL 122

  Fly   130 ACLSSMEQRCYWPRGKVLGGTSVLNGMMYVRGNREDYDDWAADGNPGWAYNDVLPFFKKSEDNLD 194
            :|.......|..||||:|||||.:|.|:|.||||.|:|.|||.|||||:|::|||:|.:|| :..
  Fly   123 SCHGMNNNECALPRGKILGGTSSINYMIYNRGNRRDFDAWAAAGNPGWSYDEVLPYFLRSE-HAQ 186

  Fly   195 LDEVGTE---YHAKGGLLPVGKFPYNPPLSYAILKAGEELGFSVHDLNGQNSTGFMIAQMTARNG 256
            |.  |.|   ||...|.|.|....:...:..|.::|..|.|....|.||::..|....|....||
  Fly   187 LQ--GLEQSPYHNHSGPLSVEYVRFRSQMVDAFVEASVESGLPRTDYNGESQLGVSYVQANTLNG 249

  Fly   257 IRYSSARAFLRPAR-MRNNLHILLNTTATKILIHPHTKNVLGVEVSDQFGSTRK---ILVKKEVV 317
            .|:|:..|:::|.| :|:||.|...:..|:|||...||:..|||    |....|   ...:|||:
  Fly   250 RRHSAYSAYIKPVRDLRSNLQIFTFSQVTRILIDEATKSAYGVE----FHYKNKAYTFKARKEVI 310

  Fly   318 LSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHNHVTYFTNFFIDDAD-----TAP 377
            ||||:.|||.:|:|||:||:|.|:.:.:..:..|| |||.:.:|:.:|...|:.:..     |:.
  Fly   311 LSAGSFNSPQLLMLSGIGPEDNLRGIGIPLIKALP-VGKRMFDHMCHFGPTFVTNTTGQTTFTSR 374

  Fly   378 LNWATAMEYLLFRDGL--MSGTGISDVTAKLATRYADSP-ERPDLQLYF-GGYLASCARTG-QVG 437
            :..|..:.:||..:..  ||..|..:..|.|.|:.::.| :.||::|.. .|.|||...|| ::|
  Fly   375 VTPAELISFLLAGNPATRMSSIGGVEALAFLKTQRSNLPNDWPDIELIMVTGSLASDEGTGLKLG 439

  Fly   438 -------------ELLSNNSRSIQIFPAVLNPRSRGFIGLRSADPLEPPRIVANYLTHEQDVKTL 489
                         ||.........:.....:|:|.|.:.|:..:||..|:|...|...|:||:.|
  Fly   440 ANFKDEIYDRMYRELAQAQQDHFTLLIMQFHPKSVGRLWLKDRNPLGWPKIDPKYFVAEEDVEYL 504

  Fly   490 VEGIKFVIRLSQTTPLKQYGMRLDKTVVKGCEAHAFGSDAYWECAVRQNTGPENHQAGSCKMGPS 554
            ::|||..:|:.:...:::.|.||.|..|.|||.|.|.||.||.|::|..:...:||..:|:||..
  Fly   505 LDGIKASLRIIEMPAMQRIGARLLKRTVPGCEGHQFASDDYWRCSIRTLSYTLHHQVATCRMGAE 569

  Fly   555 HDPMAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKGAYLLKRAW 608
            .||..||||:|:|||:|.|||:||||:|...:.:|:|.|.||.||.|.:::..|
  Fly   570 SDPTTVVNHQLKVHGVRKLRVVDTSIIPFPPTAHTNAAAFMIGEKAADMIRTDW 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	19/29 (66%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	215/565 (38%)
CG12539	NP_572976.1	PRK02106	58..620	CDD:235000	216/569 (38%)
		NADB_Rossmann	59..>90	CDD:304358	20/30 (67%)
		NADB_Rossmann	128..355	CDD:304358	97/234 (41%)
		GMC_oxred_C	471..615	CDD:282984	63/143 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I2249
eggNOG	1	0.900	-	-		E1_COG2303
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	1	1.100	-	-	P	PTHR11552
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
	10	9.870