DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gld and Chdh

DIOPT Version :9

Sequence 1:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_942026.1	Gene:	Chdh / 290551	RGDID:	735166	Length:	599	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	207/591 - (35%)
Similarity:	305/591 - (51%)	Gaps:	77/591 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PCGRASSRFRSEPDYEYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAG-GDEPVGAQ------- 105
            ||..|.:...|....||.|||:|.||||.|:|:||:|.|..:|||:||| .|..:|::
  Rat    30 PCSCAVASAASGGKDEYTFIVVGAGSAGCVLANRLTEDPNHRVLLLEAGPKDLLMGSKRLQWKIH 94

  Fly   106 IP-SMFLNFIGSDIDYRYNTEPEPMACLSSMEQR-CYWPRGKVLGGTSVLNGMMYVRGNREDYDD 168
            :| ::..|......::.|:||.:|     .::.| .|||||:|.||:|.||.|:|:||:.|||:.
  Rat    95 MPAALVANLCDDKYNWYYHTEAQP-----GLDGRVLYWPRGRVWGGSSSLNAMVYIRGHAEDYNR 154

  Fly   169 WAADGNPGWAYNDVLPFFKKSEDNLDLDEVGTE-YHAKGGLLPVGKFPYNPPLSYAILKAGEELG 232
            |...|..||.|...||:|:|::.:    |:|.. |....|.|.|.:...|.||..|.|:|..:.|
  Rat   155 WHRQGAEGWDYAHCLPYFRKAQKH----ELGANMYRGGDGPLHVSRGKTNHPLHQAFLQAARQAG 215

  Fly   233 FS-VHDLNGQNSTGFMIAQMTARNGIRYSSARAFLRPARMRNNLHILLNTTATKILIHPHTKNVL 296
            :. ..|:||....||....||...|.|:|:|.|:||||..|.||...:.|..:::|.  .....:
  Rat   216 YPFTEDMNGFQQEGFGWMDMTIHQGKRWSTASAYLRPALSRPNLRAEVQTLVSRVLF--EGTRAV 278

  Fly   297 GVE-VSDQFGSTRKILVKKEVVLSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHN 360
            ||| :.|  |.:.|..|.:||:||.||:|||.:|:|||||..|:|:::.:..|.:|||||:||.:
  Rat   279 GVEYIKD--GQSHKAYVSREVILSGGAINSPQLLMLSGVGNADDLKKLGIPVVCHLPGVGQNLQD 341

  Fly   361 HVTYFTNFFIDDADTAPLNWATAMEYL---------LFRDGLMSGTGISDVTAKLAT----RYAD 412
            |:    ..:|..|.|.|:...:|.:.|         |:|   .:|.|   .||.|.|    |...
  Rat   342 HL----EIYIQHACTQPITLHSAQKPLRKVCIGLEWLWR---FTGDG---ATAHLETGGFIRSRP 396

  Fly   413 SPERPDLQLYFGGYLASCARTGQVGELLSNNSR-----SIQIFPAVLNPRSRGFIGLRSADPLEP 472
            ....||:|.:|   |.|        :::.:..:     :.|:....:...|.|::.|||.:|.:.
  Rat   397 GVPHPDIQFHF---LPS--------QVIDHGRKPTQQEAYQVHVGTMRATSVGWLKLRSTNPQDH 450

  Fly   473 PRIVANYLTHEQDVKTLVEGIKF---VIRLSQTTPLKQYGMRLDKTVVKGCEAHAFGSDAYWECA 534
            |.|..|||:.|.||:...:.:|.   :.......|.:...::....|....|..||
  Rat   451 PMINPNYLSTETDVEDFRQCVKLTREIFAQEAFAPFRGKELQPGSHVQSDKEIDAF--------- 506

  Fly   535 VRQNTGPENHQAGSCKMGPSHDPMAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEK 599
            ||.......|.:.:||||...||.|||:.:.||.|:..|||:|.||||.|.|||.:||.:|||||
  Rat   507 VRAKADSAYHPSCTCKMGQPSDPTAVVDQQTRVIGVENLRVIDASIMPSVVSGNLNAPTIMIAEK 571

  Fly   600 GAYLLK 605
            .|.::|
  Rat   572 AADVIK 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	23/45 (51%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	201/570 (35%)
Chdh	NP_942026.1	PRK02106	45..591	CDD:235000	203/576 (35%)
		NADB_Rossmann	49..>151	CDD:304358	43/106 (41%)
		GMC_oxred_N	121..344	CDD:279121	95/234 (41%)
		GMC_oxred_C	435..572	CDD:282984	53/145 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	244	1.000	Domainoid score	I2129
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2269
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm44531
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.740