DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gld and Chdh

DIOPT Version :9

Sequence 1:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001129712.1	Gene:	Chdh / 218865	MGIID:	1860776	Length:	596	Species:	Mus musculus

Alignment Length:	590	Identity:	211/590 - (35%)
Similarity:	310/590 - (52%)	Gaps:	78/590 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PCGRASSRFRSEPDYEYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAG-GDEPVGAQ------- 105
            ||.||.:....:   ||.|:|:|.||||.|:||||:|.|..:|||:||| .|..:|::
Mouse    30 PCSRAVASVGKD---EYTFVVVGAGSAGCVLASRLTEDPNHRVLLLEAGPKDLLMGSKRLQWKIH 91

  Fly   106 IPSMFL-NFIGSDIDYRYNTEPEPMACLSSMEQR-CYWPRGKVLGGTSVLNGMMYVRGNREDYDD 168
            :|:..: |......::.|:|||:|     .|:.| .|||||:|.||:|.||.|:|:||:.|||:.
Mouse    92 MPAALVSNLCDDKYNWYYHTEPQP-----GMDSRVLYWPRGRVWGGSSSLNAMVYIRGHAEDYNR 151

  Fly   169 WAADGNPGWAYNDVLPFFKKSEDNLDLDEVGTE-YHAKGGLLPVGKFPYNPPLSYAILKAGEELG 232
            |..:|..||.|...||:|:|::.:    |:|.. |....|.|.|.:...|.||..|.|:|..:.|
Mouse   152 WHREGAEGWDYAHCLPYFRKAQRH----ELGANMYRGGDGPLHVSRGKTNHPLHQAFLQAARQAG 212

  Fly   233 FS-VHDLNGQNSTGFMIAQMTARNGIRYSSARAFLRPARMRNNLHILLNTTATKILIHPHTKNVL 296
            :. ..|:||....||....||...|.|:|:|.|:|.|...|.||...:.|..:::|.  .....:
Mouse   213 YPFTEDMNGFQQEGFGWMDMTVHQGKRWSTACAYLHPVLSRPNLRAEVQTLVSRVLF--EGTRAV 275

  Fly   297 GVE-VSDQFGSTRKILVKKEVVLSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHN 360
            ||| :.|  |...|..|.:||:||.||:|||.:|:|||||..|:|:::::..|.:|||||:||.:
Mouse   276 GVEYIKD--GQRHKAYVSREVILSGGAINSPQLLMLSGVGNADDLRKLDIPVVCHLPGVGQNLQD 338

  Fly   361 HVTYFTNFFIDDADTAPLNWATAMEYL----LFRDGLMSGTGISDVTAKLAT----RYADSPERP 417
            |:    ..::..|.|.|:...:|.:.|    :..:.|.|.|| ...||.|.|    |.......|
Mouse   339 HL----EVYVQQACTQPITLHSAQKPLRKVCIGLEWLWSYTG-DGATAHLETGGFIRSRPGVPHP 398

  Fly   418 DLQLYFGGYLASCARTGQVGELLSNNSR-----SIQIFPAVLNPRSRGFIGLRSADPLEPPRIVA 477
            |:|.:|   |.|        :::.:..:     :.|:....:...|.|::.||||:|.:.|.|..
Mouse   399 DIQFHF---LPS--------QVIDHGRKPTQQEAYQVHVGTMRATSVGWLKLRSANPRDHPVIHP 452

  Fly   478 NYLTHEQDVKTLVEGIKFVIRLSQ-------TTPLKQYGMRLDKTVVKGCEAHAFGSDAYWECAV 535
            |||:.|.|    ||..:..:|||:       ..|.:...::....|....|..||         |
Mouse   453 NYLSTETD----VEDFRQCVRLSREIFAQEALAPFRGKELQPGSHVQSDKEIDAF---------V 504

  Fly   536 RQNTGPENHQAGSCKMGPSHDPMAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKG 600
            |.......|.:.:||||.|.||.|||:.:.:|.|:..|||:|.||||.|.|||.:||.||||||.
Mouse   505 RAKADSAYHPSCTCKMGRSSDPTAVVDAQTKVIGVENLRVVDASIMPSVVSGNLNAPTVMIAEKA 569

  Fly   601 AYLLK 605
            |.::|
Mouse   570 ADIIK 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	23/45 (51%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	205/569 (36%)
Chdh	NP_001129712.1	PRK02106	42..588	CDD:235000	207/575 (36%)
		NAD_binding_8	47..>76	CDD:290186	18/28 (64%)
		GMC_oxred_N	118..341	CDD:279121	93/234 (40%)
		GMC_oxred_C	432..569	CDD:282984	58/149 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	241	1.000	Domainoid score	I2232
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm42468
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.730