DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gld and chdh-1

DIOPT Version :9

Sequence 1:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_495846.1	Gene:	chdh-1 / 174390	WormBaseID:	WBGene00007917	Length:	599	Species:	Caenorhabditis elegans

Alignment Length:	577	Identity:	190/577 - (32%)
Similarity:	291/577 - (50%)	Gaps:	74/577 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 IVIGGGSAGSVVASRLSEVPQWKVLLIEAGGDEPVG------AQIP-SMFLNFIGSDIDYRYNTE 125
            |::|.||||.|:|:||:|.|..:|||||||   ||.      ..:| ::..|......::.|:|.
Worm    41 IIVGAGSAGCVLANRLTEDPSNRVLLIEAG---PVDHKWDWRIHMPAALMYNLCSDTYNWHYHTT 102

  Fly   126 PEPMACLSSMEQRC-YWPRGKVLGGTSVLNGMMYVRGNREDYDDWAADGNPGWAYNDVLPFFKKS 189
            .:     .::..|. |||||:|.||:|.||.|.||||:..||:.|..:|..||.|.:.||:|||:
Worm   103 AQ-----KNLGNRVFYWPRGRVWGGSSTLNAMCYVRGHAYDYNRWEKEGASGWNYANCLPYFKKA 162

  Fly   190 EDNLDLDEVGTEYHAKGGLLPVGKFPYNPPLSYAILKAGEE--LGFSVHDLNGQNSTGFMIAQMT 252
            |...|.......|....|.|.|.|.....||..|.|..|:|  ||:: :|:||:...|.....||
Worm   163 ETYSDATGPNDPYRGNNGPLYVKKGDAENPLHKAWLNVGKEHPLGWT-NDMNGEKQEGISTMDMT 226

  Fly   253 ARNGIRYSSARAFLRPARMRNNLHILLNTTATKILIHPHTK---------NVLGVEVSDQFGSTR 308
            ..||.|:|:::|::.|.|.|.||......|.|::|...:..         |.:|.:..|.: |..
Worm   227 IHNGERWSASKAYVHPIRNRPNLITSSGITCTRVLFDTNKAIGIEFIRKLNFVGTDSIDSY-SRE 290

  Fly   309 KILVKKEVVLSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHNHVTYFTNFFIDDA 373
            ||..:.:|:|:.||:|:|.:|:||||||.|.|:...:..|.||||||:||.:|:    ..::...
Worm   291 KIYCQGDVILAGGAINTPQLLMLSGVGPADHLRSHEIPIVANLPGVGQNLQDHL----EIYVQQE 351

  Fly   374 DTAPL------NW-------ATAMEYLLFRDGLMSGTGISDVTAKLATRYADSPERPDLQLYFGG 425
            .|.|:      :|       ...:|:...|.||.:.:.:.  |...| |..|:...||:|.:|
Worm   352 STQPVTLYNKSSWKFPHNMIKIGLEWFTNRTGLGASSHLE--TGGFA-RSDDTVTHPDIQFHF-- 411

  Fly   426 YLASC----ARTGQVGELLSNNSRSIQIFPAVLNPRSRGFIGLRSADPLEPPRIVANYLTHEQDV 486
             |.|.    .||       :......|:....:..:|:|:|.|::.||...|.|..||:..:.|.
Worm   412 -LPSTVHDDGRT-------NGTCHGYQVHVGPMRSQSKGYIMLQAKDPRRAPIINPNYMEEDSDW 468

  Fly   487 KTLVEGIKFVIRLSQTTPLKQYGMRLDKTVVKG--CEAHAFGSDAYWECAVRQNTGPENHQAGSC 549
            :...:.|:....|..:....::   ..|.:..|  |:     |||..:..|::......|.:.:|
Worm   469 REFRKCIRVSRELFASKAFDEF---RGKELAPGPDCQ-----SDADIDRFVKEKAASAYHPSCTC 525

  Fly   550 KMGPSHDPMAVVNHE-LRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKGAYLLK 605
            |||..:|.|||||.| :.|:|...|:|:|.|:||.:.|||.:||.:|:||:.|.|:|
Worm   526 KMGSENDKMAVVNPETMGVYGTENLKVVDASVMPSIVSGNLNAPVIMMAERAADLIK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	15/26 (58%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	187/571 (33%)
chdh-1	NP_495846.1	PRK02106	41..599	CDD:235000	190/577 (33%)
		NADB_Rossmann	41..>78	CDD:304358	21/39 (54%)
		NADB_Rossmann	108..345	CDD:304358	94/242 (39%)
		GMC_oxred_C	439..577	CDD:282984	48/145 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	214	1.000	Domainoid score	I1583
eggNOG	1	0.900	-	-		E1_COG2303
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I1553
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm14159
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.740