DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gld and chdh

DIOPT Version :9

Sequence 1:	NP_001350861.1	Gene:	Gld / 40875	FlyBaseID:	FBgn0001112	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_002663301.2	Gene:	chdh / 100331020	ZFINID:	ZDB-GENE-120111-1	Length:	585	Species:	Danio rerio

Alignment Length:	573	Identity:	206/573 - (35%)
Similarity:	308/573 - (53%)	Gaps:	61/573 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 RSEPDYEYDFIVIGGGSAGSVVASRLSEVPQWKVLLIEAG-GDEPVGA-------QIP-SMFLNF 113
            ::.|.|.|  :::|.||||.|:||||:|.|...|||:||| .|:.:|:       .:| ::..|.
Zfish    30 KNTPSYSY--VIVGAGSAGCVLASRLTENPSDSVLLLEAGPKDKHLGSTRLSWKIHMPAALTYNL 92

  Fly   114 IGSDIDYRYNTEPEPMACLSSMEQR-CYWPRGKVLGGTSVLNGMMYVRGNREDYDDWAADGNPGW 177
            .....::.|:|.|:     :.|:.| .|||||:|.||:|.||.|:|:||:.|||:.|.::|..||
Zfish    93 CDDRYNWFYHTLPQ-----AHMDDRVMYWPRGRVWGGSSSLNAMVYIRGHAEDYNRWQSEGADGW 152

  Fly   178 AYNDVLPFFKKSEDNLDLDEVGTE-YHAKGGLLPVGKFPYNPPLSYAILKAGEELGFS-VHDLNG 240
            .|:..||:|:|::.:    |:|.: |....|.|.|.:.....||.||.::||::.|:. ..|:||
Zfish   153 NYDHCLPYFRKAQTH----ELGPDRYRGGDGPLHVSRGKTQNPLHYAFIQAGQQAGYPYTEDMNG 213

  Fly   241 --QNSTGFMIAQMTARNGIRYSSARAFLRPARMRNNLHILLNTTATKILIHPHTKNVLGVEVSDQ 303
              |...|:|  .||...|.|:|:|.|:||||..|.||...:....|::|.  ......|||. .|
Zfish   214 FQQEGVGWM--DMTIHKGQRWSTASAYLRPALSRPNLSTEVRCMVTRVLF--DGARARGVEY-QQ 273

  Fly   304 FGSTRKILVKKEVVLSAGAVNSPHILLLSGVGPKDELQQVNVRTVHNLPGVGKNLHNHVTYFTNF 368
            .|..:|:..:|||:||.||:|||.:|||||||..|||:.:::..|.:|||||.||.:|:    ..
Zfish   274 NGQIKKVFAEKEVILSGGAINSPQLLLLSGVGNADELKTLDIPVVQHLPGVGCNLQDHL----EL 334

  Fly   369 FIDDADTAPLNWATAMEYL-LFRDG---LMSGTGISDVTAKLAT----RYADSPERPDLQLYFGG 425
            ::..|.|.|:....|.:.| :.:.|   |:..||.. .||.|.:    |.......||:|.:|
Zfish   335 YVQHACTQPITLYRAQKPLQMLKIGLEWLLKFTGYG-ATAHLESGGFIRSRPDVPHPDIQFHF-- 396

  Fly   426 YLASCARTGQVGELLSNNSRSIQIFPAVLNPRSRGFIGLRSADPLEPPRIVANYLTHEQDVKTLV 490
            ..:.....|:|    |:...:.|:....:...|.|::.|:|.||.:.|.:..|||:.|.||....
Zfish   397 LPSQVIDHGRV----SSKIEAFQVHVGPMRSTSVGWLKLKSKDPRDHPILQPNYLSTETDVLEFR 457

  Fly   491 EGIKFVIRLSQTTPLKQYGMRLDKTVVKGCEAH---AFGSDAYWECAVRQNTGPENHQAGSCKMG 552
            |.::....:.......::         :|.|..   |..|||..:..|||......|.:.:||||
Zfish   458 ECVRLTREIFAQQAFDEF---------RGPEVQPGPAVQSDAEIDAFVRQKADSAYHPSCTCKMG 513

  Fly   553 PSHDPMAVVNHELRVHGIRGLRVMDTSIMPKVSSGNTHAPAVMIAEKGAYLLK 605
            ...|.||||:.||||.|:.||||:|.|:||.:.|||.:||.:|||||.|..:|
Zfish   514 RPEDRMAVVSPELRVFGVEGLRVVDASVMPSMVSGNLNAPTIMIAEKAADAIK 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gld	NP_001350861.1	Pyr_redox_dim	29..>95	CDD:332164	18/36 (50%)
Gld	NP_001350861.1	GMC_oxred_C	64..601	CDD:331873	202/561 (36%)
chdh	XP_002663301.2	PRK02106	30..585	CDD:235000	206/573 (36%)
		NADB_Rossmann	38..>69	CDD:304358	18/30 (60%)
		GMC_oxred_N	110..333	CDD:279121	98/235 (42%)
		GMC_oxred_C	424..561	CDD:282984	55/145 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	241	1.000	Domainoid score	I2198
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2314
OMA	1	1.010	-	-		QHG52181
OrthoDB	1	1.010	-	-		D173099at33208
OrthoFinder	1	1.000	-	-		FOG0000165
OrthoInspector	1	1.000	-	-		otm24368
orthoMCL	1	0.900	-	-		OOG6_100146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880