DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1234 and Noc3l

DIOPT Version :9

Sequence 1:	NP_649710.1	Gene:	CG1234 / 40870	FlyBaseID:	FBgn0037489	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_001101993.1	Gene:	Noc3l / 361753	RGDID:	1560656	Length:	799	Species:	Rattus norvegicus

Alignment Length:	814	Identity:	282/814 - (34%)
Similarity:	443/814 - (54%)	Gaps:	79/814 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKVKISSVKRAAHLKSKKTPLSKQQQQKQKQKRDQLKSKREQGQNIFSQKARKRDNLAQRKKHNK 68
            |.:|.|.||....||:|:   .|||...:|.:::|.| .|:..::..|:|....::...::...:
  Rat    15 KLIKTSKVKLENKLKNKQ---FKQQSTIKKYRKEQRK-LRQAVKDAVSKKPFPLEDPKSKRPVKR 75

  Fly    69 LASLGLDPLEEDNEDGDDEMLENVADMLDGDDLALLQANKRKRKAKTTGENDPDQGQSIGL-ERA 132
            :         |..|:.::|.|.  .||||.|||.|::...:|....|   .|....:.:.: :|.
  Rat    76 I---------EREEEDEEEALP--LDMLDEDDLQLIKDLGQKASFLT---RDLSSSEPVHIKKRK 126

  Fly   133 YASDTKKEQDA--------QKIKLDLLPIKSRDGQIITRTTEVDYIPKPKQKKKNEEEEEDDSEE 189
            :.|..:|.:..        :|..:.|||||.:.| ||.:|.|     ||....:.|||||::.|
  Rat   127 HESVIEKYEKVPRTLQTAPEKELIHLLPIKDKSG-IIPQTRE-----KPVTAIQQEEEEEEEPE- 184

  Fly   190 DGDTEYEDSDDDVVNDVEAATAAPVQKLISTTDLLIARQQEIERQKYRIGIICSGLLEKPEDKMR 254
                    .:::|:.:       |.|:| :..:.:|.|:::::.:|.:|..:.|.:|..||..::
  Rat   185 --------VEEEVIEE-------PRQEL-TIEEHVIERKKKLQDKKIQIATLASAILSDPESHIK 233

  Fly   255 NFHALYELMDEINPASRQANLMAVRKLAIISVTEIFKDILPEYRVGQVD--TKMQTLRKATLDRV 317
            ....|..::.|.:|..    .:.||||||||:.|:||||.|.|::..:.  .|...:||.|....
  Rat   234 KLKELRAMLMEQDPDV----AVTVRKLAIISLMELFKDITPSYKIRPLTEAEKSAKIRKETQKLR 294

  Fly   318 TFENALLQQFKKFLQKLEQITAQVNRRGGLRTPQTVK------LATVAVQCMCDLLVAHPYFNYV 376
            .||..|:.|:|.:|:.||||.....:| .|:....|.      ||.|||:.:|:||||.|:||:.
  Rat   295 EFEEGLVSQYKFYLENLEQIVKDWKQR-KLKKSNVVSLKAYKGLAEVAVKSLCELLVALPHFNFH 358

  Fly   377 QNIAQLLVYMLNCNYAEMRTAVHQCFRTVFSNDKRLEMTLFIVRRINHLIKTKQNNVHVECITCL 441
            .||..|:|.::|.....:.....:..:.:|..||..:.:|.:::.|:..:|.:...|..|.:...
  Rat   359 NNIIVLIVPLMNDGSKSVSEMCCEAVKKLFKQDKLGQASLGVIKVISGFVKGRNYEVRPEMLKTF 423

  Fly   442 MGLKIKNVNLDAEKENELKQKKLESHRQRLLSLSKKERKRRKKLTEVNRELEETRAEENKQAKHQ 506
            :.|:||.|.:..:.|:..|.|:..:.:::..:||:.:||.:|...::.|||.|..|.|:.:.|.:
  Rat   424 LCLRIKEVEVKKDTEDINKPKRFMTFKEKRKTLSRMQRKWKKAEEKLERELREAEASESTEKKLK 488

  Fly   507 KLTEIIKMVFTIYFRVLKNDPTSRVLSAILEGLAEFAHVINLDFFSDLIDVLNRILEDQDELGYR 571
            ..||.:.:||..|||:||....|.:|.|:|||||:|||:||::||.||:.||:.::|..| |.|:
  Rat   489 LHTETLNIVFVTYFRILKKAQKSPLLPAVLEGLAKFAHLINVEFFDDLLVVLHTLIESGD-LSYQ 552

  Fly   572 ERLHCVQTIFVILSGQGEVLNIDPIRFYQHFYRNMLAVQAGKNHDDFAIILRTLDEVLVKRRRNM 636
            |.||||||.|.||||||:||||||::||.|.|:.:..:.||..:|...|:|..||.:|.|||:.:
  Rat   553 ESLHCVQTAFHILSGQGDVLNIDPMKFYTHLYKTLFTLHAGATNDGIEIVLHCLDVMLTKRRKQV 617

  Fly   637 SQQRLMAFMKRLLTGSLHLLHN---GTLATLGTIKQTFQLTSVLDNLLDTDTTIGSGRYDPELDD 698
            |.||.:||:|||.|.:|.:|.|   |.||....:..||..|   |.|||.::. |||.:.|||::
  Rat   618 SHQRALAFIKRLCTLALQVLPNSSIGLLAMTRILMHTFPRT---DLLLDNESQ-GSGVFLPELEE 678

  Fly   699 PEYCNAASTALYELALLARHYHPTVRRMAVHIAHGVPATGEGALPTEIGKLTSHELFTQFDSTQM 763
            ||||||.:|||:||..|.|||||.|||.|.|:..|.|:.|..||..|:.:.::.|||..:...:|
  Rat   679 PEYCNAQNTALWELHALRRHYHPIVRRFAAHLLAGAPSEGSEALKPELSRRSALELFEAYSMAEM 743

  Fly   764 AFNPTIPLPKAGQPKLKRGKHL----YIRSDFKQ 793
            .|||    |.......|:.|.|    ::..|..|
  Rat   744 TFNP----PVESFNSKKKDKFLQGDAFLNEDLNQ 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1234	NP_649710.1	NOC3	228..727	CDD:227447	201/509 (39%)
		NOC3p	235..330	CDD:284871	33/96 (34%)
		CBF	574..727	CDD:281851	82/155 (53%)
Noc3l	NP_001101993.1	NOC3	113..712	CDD:227447	232/631 (37%)
		NOC3p	213..307	CDD:284871	33/97 (34%)
		CBF	554..707	CDD:281851	82/156 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343389
Domainoid	1	1.000	155	1.000	Domainoid score	I4145
eggNOG	1	0.900	-	-		E1_COG5117
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39642
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1820
OMA	1	1.010	-	-		QHG55337
OrthoDB	1	1.010	-	-		D169864at33208
OrthoFinder	1	1.000	-	-		FOG0004096
OrthoInspector	1	1.000	-	-		oto96212
orthoMCL	1	0.900	-	-		OOG6_102758
Panther	1	1.100	-	-	LDO	PTHR14428
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2841
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770