DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1234 and noc3l

DIOPT Version :9

Sequence 1:	NP_649710.1	Gene:	CG1234 / 40870	FlyBaseID:	FBgn0037489	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_001002863.1	Gene:	noc3l / 321289	ZFINID:	ZDB-GENE-030131-9878	Length:	800	Species:	Danio rerio

Alignment Length:	833	Identity:	285/833 - (34%)
Similarity:	458/833 - (54%)	Gaps:	78/833 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PLSKQQQQKQKQKRDQLKSKREQGQN------IFSQKARKRDNLAQRKKHNKLASLG---LDPLE 78
            |.||:.::|:...|..||:...:.:|      ...|.:.|:....|||.|..::.:.   |.|||
Zfish     3 PASKRNKKKRPSFRKLLKTSNLKLENKLKNRQFKQQSSAKKQRKEQRKLHKAISDVSHQTLKPLE 67

  Fly    79 E-----DNEDGDDEMLENV-ADMLDGDDLALLQANKRKRKAKT----------TGENDPDQGQSI 127
            .     ::|:.::|.||:: .||:|.|||..::|..:|....|          ..::..:|
Zfish    68 RYKKRPEDEEEEEEFLESLPTDMMDEDDLEHIRAIAQKASFLTRDLSSCAPVHAKKHKSEQ---- 128

  Fly   128 GLERAYASDTKKEQDAQKIKLDLLPIKSRDGQIITRTTEVDYIPKPKQKKKNEEEEEDDSEEDGD 192
            .||.......|.:|:.:|..:.|||||.:.| :|.::.|...:|:.      |||||:.::|
Zfish   129 ALENYEKMPRKMQQEEEKELIHLLPIKDKSG-LIPQSMEKPVLPQA------EEEEEEPNQE--- 183

  Fly   193 TEYEDSDDDVVNDVEAATAAPVQKLISTTDLLIARQQEIERQKYRIGIICSGLLEKPEDKMRNFH 257
             .|...:       |...:||   |::..:....|.|::..:|.||..:.|.:|..|...::...
Zfish   184 -VYLQKE-------EEPESAP---LLTPQEQFEQRAQKLMEKKLRIAALSSAILADPHVNIKKLK 237

  Fly   258 ALYELMDEINPASRQANLMAVRKLAIISVTEIFKDILPEYRVGQV--DTKMQTLRKATLDRVTFE 320
            .|..::.|.:|..    .:.||||.::|:.|:||||:|.||:..:  :.|...::|.||....||
Zfish   238 ELRAMLMETDPCV----AVTVRKLVMVSLMEVFKDIVPAYRIRPLTEEEKAAKVKKETLQLREFE 298

  Fly   321 NALLQQFKKFLQKLEQITAQVNRRGGLRTP----QTVK-LATVAVQCMCDLLVAHPYFNYVQNIA 380
            ..|:.|:|.:|::|||......::...|:.    |:.| ||.|||:|:|:||||.|:||:..||.
Zfish   299 EGLVSQYKFYLEELEQTVKDWKQKKEKRSQAVSLQSYKGLAEVAVRCICELLVALPHFNFHNNII 363

  Fly   381 QLLVYMLNCNYAEMRTAVHQCFRTVFSNDKRLEMTLFIVRRINHLIKTKQNNVHVECITCLMGLK 445
            .:||.::|.:..::.....:..:.:...||..:.:|.:|:.|:.::|::...:....:.||:.|:
Zfish   364 VMLVPLMNDSDKKVSEMCCEAVKKLLKQDKVGQASLAMVKVISGMVKSRNYRIKPVVLNCLLCLR 428

  Fly   446 IKNVNLDAEKENELKQKKLESHRQRLLSLSKKERKRRKKLTEVNRELEETRAEENKQAKHQKLTE 510
            ||.|::..:.|:...:||..|.:::..:||:.:||.:|...::.:||.|..|.|:|:.|.:..||
Zfish   429 IKEVDMKKDTEDTAPKKKFMSFKEKRKNLSRMQRKWKKAEEKLQKELLEAEATESKEKKIKLHTE 493

  Fly   511 IIKMVFTIYFRVLKNDPTSRVLSAILEGLAEFAHVINLDFFSDLIDVLNRILEDQDELGYRERLH 575
            .:.:||.||||:||....|.:||::|||||:|||:|||:||.||:.||..::...| |.|||.||
Zfish   494 TLNVVFLIYFRILKKAQKSVLLSSVLEGLAKFAHLINLEFFDDLLAVLYNLITSGD-LTYRESLH 557

  Fly   576 CVQTIFVILSGQGEVLNIDPIRFYQHFYRNMLAVQAGKNHDDFAIILRTLDEVLVKRRRNMSQQR 640
            |:.|.|.||||||:||||||::||.|.||.:|.:.||..::|..|:|:.||.:|.|||:.::.||
Zfish   558 CILTSFHILSGQGDVLNIDPLKFYSHLYRTLLTLHAGGVNEDTVIVLQCLDVMLSKRRKQVTLQR 622

  Fly   641 LMAFMKRLLTGSLHLLHNGTLATLGTIKQTFQLTSVLDNLLDTDTTIGSGRYDPELDDPEYCNAA 705
            ..||:|||.|.:||||.:..:..|...:...|.....|.|||.:|. |||.|.||||.|||||..
Zfish   623 AQAFLKRLNTVALHLLPDSCVGILAANRMLMQTFPKCDILLDNETQ-GSGVYLPELDVPEYCNPQ 686

  Fly   706 STALYELALLARHYHPTVRRMAVHIAHGVPATGEGALPTEIGKLTSHELFTQFDSTQMAFNPTIP 770
            :|||:||.||..||||.||:.|.|:..|.|:.|.|||..|:.:.:..:||..:....|:|||
Zfish   687 NTALWELHLLKSHYHPVVRKFAAHLMKGAPSEGSGALGVELSRRSPLQLFEDYSVKDMSFNP--- 748

  Fly   771 LPKAGQPKLKRG----KHLYIRSDFKQEYGKLLQQGKVSQTKDKQTLQIDFFS 819
             |.||.|..|:.    .|.::.|:..::....||:       :.:.:.:||.|
Zfish   749 -PVAGPPSKKKEYFTIGHAFLHSELSRQIDAALQE-------EPEQMSLDFTS 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1234	NP_649710.1	NOC3	228..727	CDD:227447	200/505 (40%)
		NOC3p	235..330	CDD:284871	31/96 (32%)
		CBF	574..727	CDD:281851	79/152 (52%)
noc3l	NP_001002863.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		23/87 (26%)
		NOC3	121..713	CDD:227447	229/622 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..197		11/49 (22%)
		NOC3p	214..308	CDD:284871	31/97 (32%)
		CBF	555..708	CDD:281851	79/153 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	780..800		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583650
Domainoid	1	1.000	155	1.000	Domainoid score	I4190
eggNOG	1	0.900	-	-		E1_COG5117
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39642
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1671
OMA	1	1.010	-	-		QHG55337
OrthoDB	1	1.010	-	-		D169864at33208
OrthoFinder	1	1.000	-	-		FOG0004096
OrthoInspector	1	1.000	-	-		oto39321
orthoMCL	1	0.900	-	-		OOG6_102758
Panther	1	1.100	-	-	LDO	PTHR14428
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R822
SonicParanoid	1	1.000	-	-		X2841
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800