DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1234 and C37H5.5

DIOPT Version :9

Sequence 1:	NP_649710.1	Gene:	CG1234 / 40870	FlyBaseID:	FBgn0037489	Length:	822	Species:	Drosophila melanogaster
Sequence 2:	NP_504292.2	Gene:	C37H5.5 / 178874	WormBaseID:	WBGene00016508	Length:	778	Species:	Caenorhabditis elegans

Alignment Length:	790	Identity:	229/790 - (28%)
Similarity:	404/790 - (51%)	Gaps:	85/790 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSVKRAAHLKSKKTPLSKQQQQKQKQKRDQLKSKREQGQNIFSQKARKRDNLAQRKKHNKLASLG 73
            :|..|...||..||..:::..:...:...:.|..||....:...|:||..:|.||..:
Worm     4 ASASREEKLKMLKTNKTRKTTKHLNRLAKRKKLSREIRDGMADIKSRKSADLRQRAVN------- 61

  Fly    74 LDPLEED--------NEDGDDEMLENVADMLDGD----DLALLQANKRKRKAKTTGENDPDQGQS 126
               :|:|        .|:.|:::   ..||:|.|    :.|...|.:|..|.::..|:|.|....
Worm    62 ---IEDDFIADRQAHYENSDEDL---PLDMMDADIDWENSAFANAKRRLEKKRSGVESDSDDEDD 120

  Fly   127 IGLERAYASDTKKEQDAQKIK---LDLLPIKSRDGQIITRTTEVDYIPKPKQKKKNEEEEEDDSE 188
            :        :.||.:.|..::   .:|||||.:||.:|..|.|       |:.|::|||:..|.|
Worm   121 V--------EKKKRKFAGLLEEGHEELLPIKLKDGTLIRPTRE-------KEVKEDEEEKSGDEE 170

  Fly   189 EDGDTEYEDSDDDVVNDVEAATAAPVQKLISTTDLLIARQQEIERQKYRIGIICSGLLEKPEDKM 253
            |:|: |.|...:|..:             :|.::|:..|::.::..|..|....:.||..|:..:
Worm   171 EEGE-EDEPHREDFSH-------------LSASELIAKRRELMQEFKDTIASHANMLLSNPQVNI 221

  Fly   254 RNFHALYELM--DEINPASRQANLMAVRKLAIISVTEIFKDILPEYRVGQ--VDTKMQTLRKATL 314
            .....||.|.  ::|:...|:    :|:||||.|..::..||||.|.:.:  .:.|.|..:|.|.
Worm   222 VRLRDLYNLCNGEKIHSLVRE----SVQKLAIASTLQVLLDILPGYAIREQTAEEKAQKQKKETR 282

  Fly   315 DRVTFENALLQQFKKFLQKLEQITAQV--NRRGGLRTPQTVKLATVAVQCMCDLLVAHPYFNYVQ 377
            :.|.:|.:||:...|:||..|:::.::  ..|....:..|.|:..::|:.:..::|:.|:|||..
Worm   283 NLVNYEESLLRYHLKYLQLCEKLSNKLVGKDRHNDESTFTFKMGILSVKALARIVVSAPHFNYST 347

  Fly   378 NIAQLLVYMLNCNYAEMRTAVH---QCFRTVFSNDKRLEMTLFIVRRINHLIKTKQNNVHVECIT 439
            ||...||.:   :.|:..|.:.   :..||||..|..|::|||..|.|:.|:..::..|..|.:.
Worm   348 NIVSSLVRL---SLAKNETVIREVCEAIRTVFKEDIHLKITLFTARSISTLVTKRKGRVPPELLR 409

  Fly   440 CLMGLKIKNVNLDAEK--ENELKQKKLESHRQRLLSLSKKERKRRKKLTEVNRELEETRAEENKQ 502
            .|:.:.|..|..:.:|  ::.|..||.:..:::   .||..:|.:|:|..:..:|.|..|||:..
Worm   410 TLLSMNITEVKDEDKKSGKDALIAKKYQIKKEK---ASKTAKKYKKQLARLEADLLEVEAEESMS 471

  Fly   503 AKHQKLTEIIKMVFTIYFRVLKNDPTSRVLSAILEGLAEFAHVINLDFFSDLIDVLNRILEDQDE 567
            .|.:..||.:|..|..||.:||..|.|.:|..:||||::|||:::::|:.|::..:..::::::
Worm   472 KKLKNATEAMKFAFQSYFSILKRMPNSALLEPVLEGLSKFAHLLSIEFYEDIVSTMENMVQNEN- 535

  Fly   568 LGYRERLHCVQTIFVILSGQGEVLNIDPIRFYQHFYR--NMLAVQAGKNHDDFAIIL--RTLDEV 628
            |...::|||:.|:||||||.|::|||||.:||:..||  |.|..:.........||:  :||:.:
Worm   536 LKSLDQLHCINTVFVILSGDGQLLNIDPSKFYRLAYRVLNHLPFEKRPEQRKNQIIMAAKTLETM 600

  Fly   629 LVKRRRNMSQQRLMAFMKRLLTGSLHLLHNGTLATLGTIKQTFQLTSVLDNLLDTDTTIGSGRYD 693
            ||.||:.:...|:.||:||||:.:..|.....|..:..::..|.....|.::::.:.....|.|.
Worm   601 LVIRRKAVPLSRVAAFVKRLLSIATVLDDFPALCIVSLVRSLFIAHPKLSSMIEDEEGGAPGIYR 665

  Fly   694 PELDDPEYCNA-ASTALYELALLARHYHPTVRRMAVHIAHGVPATGEGALPTEIGKLTSHELFTQ 757
            |::|||:..|| ||....||::|||..:..:.|.|.:|.:|||:||...|..::..|....|..|
Worm   666 PDIDDPDVANALASDVRDELSMLARRRNTELSRFANNILYGVPSTGIFKLNPQLSSLKPWILMGQ 730

  Fly   758 -FDSTQMAFN 766
             .|:.:.|::
Worm   731 LMDNAKDAYD 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1234	NP_649710.1	NOC3	228..727	CDD:227447	158/514 (31%)
		NOC3p	235..330	CDD:284871	29/98 (30%)
		CBF	574..727	CDD:281851	57/157 (36%)
C37H5.5	NP_504292.2	NOC3	196..679	CDD:227447	150/493 (30%)
		NOC3p	203..298	CDD:284871	29/98 (30%)
		CBF	542..700	CDD:281851	57/157 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160996
Domainoid	1	1.000	120	1.000	Domainoid score	I3579
eggNOG	1	0.900	-	-		E1_COG5117
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39642
Inparanoid	1	1.050	295	1.000	Inparanoid score	I1670
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55337
OrthoDB	1	1.010	-	-		D169864at33208
OrthoFinder	1	1.000	-	-		FOG0004096
OrthoInspector	1	1.000	-	-		oto17874
orthoMCL	1	0.900	-	-		OOG6_102758
Panther	1	1.100	-	-	LDO	PTHR14428
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R822
SonicParanoid	1	1.000	-	-		X2841
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840