Protein Alignment CG14605 and SLC2A3

DIOPT Version :10

• Sequence 1: NP_649707.3
• Gene: CG14605 / 40867
• FlyBaseID: FBgn0037486
• Length: 432
• Species: Drosophila melanogaster
• Sequence 2: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 107/408 - (26%)
• Similarity: 190/408 - (46%)
• Gaps: 36/408 - (8%)

  Fly    40 ASFGIGCLICNMVICVPVSYFGIKKCMYFVPLPNILN--WVLIYFASKSLYFYVC-RVLLGISGG 101
            |.|.:|.:|.:..:.:.|:.||.:..|..|.|..:..  ::.:...:||:...:. |:::|:..|
Human    68 AIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCG 132

  Fly   102 TLVVCFPVFIAEVSDNSVRGTLGSFFMMTLCSGITVG--FVLVYCL-SYHVLPCVVIF--LPILY 161
            ......|::|.|:|..::||..|:...:.:..||.|.  |.|.:.| |..:.|.::.|  ||.:.
Human   133 LCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAIL 197

  Fly   162 LCLIIPL-PEPPQDLL-KRGHEEKAE---KSFCFYKNLSKDPAQQDDNKAEFDKLRNKVLASGIA 221
            ....:|. ||.|:.|| .|..||.|:   :.....:::|:|..:..|..|...:          .
Human   198 QSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQ----------E 252

  Fly   222 EKITPADFFNKVSGKAFGLIAVLL-LSNQMSGSFAIFNYSSTIFEQLGSRMEPNLCGIFLGVVQI 285
            :::|..:.|...|.:...:|:::| ||.|:||..|:|.||:.||:..|.: ||....|..|||..
Human   253 KQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQ-EPIYATIGAGVVNT 316

  Fly   286 FGLISAVLLVDRVGRRLLLIPSLAGMGLAE--LGVGLLKSFASQDFLHNNGWIALTLMGIVSFTA 348
            ...:.::.||:|.|||.|.:..|.||....  :.|.||    .:|  :.||...:.:..|:.|.|
Human   317 IFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLL----LKD--NYNGMSFVCIGAILVFVA 375

  Fly   349 --SAGIVALTFVIIVELLPFKIRAPGISISMCGLSLSVFIALITYPVLINDYGVHVTMFVSASFC 411
              ..|...:.:.|:.||.....|...::::.|....|.|:..:.:|...:..|.:| ..:...|.
Human   376 FFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYV-FIIFTGFL 439

  Fly   412 LLGLVVLGIFLPETRGKS 429
            :..|......:|||||::
Human   440 ITFLAFTFFKVPETRGRT 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14605	NP_649707.3	MFS	1..432	CDD:475125	107/408 (26%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	106/405 (26%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)