DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14606 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_001334690.1	Gene:	CG14606 / 40866	FlyBaseID:	FBgn0037485	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_445946.2	Gene:	Slc2a8 / 85256	RGDID:	620611	Length:	478	Species:	Rattus norvegicus

Alignment Length:	473	Identity:	124/473 - (26%)
Similarity:	220/473 - (46%)	Gaps:	59/473 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FIATMTVHIMTLTHGIAVGWLS---PSLRLLASDESPLGDPLTITQASWVGSLIGLGSLTGNIIF 81
            |:||....:..|:.|.|:|:.|   ||||..|.....|||    |.|||.|:::.||:..|.::.
  Rat    27 FLATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGD----TAASWFGAVVTLGAAAGGVLG 87

  Fly    82 GLLLDRLGRKVCMYFLAIPNMIYWILIYSAQDVTYLYAGRFLAGMSGGGCYVVLPIFIAEIADNS 146
            |.||||.|||:.:....:|.:..:.:|.:|:||..|..||.|.|::.|...:|.|::|:|||..:
  Rat    88 GWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPA 152

  Fly   147 VRGALSSMAMMYVSIGMMVGFTLASYLPYYLMPCIIVALPVVFMLSVIGLSETPQYLLRRGRDDQ 211
            |||.|.|...:.|..|:::.:.....|.:..:..:....|.:.:|.:..:.|||::||.:.:..:
  Rat   153 VRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQE 217

  Fly   212 AEKSFYFYKNLTPPTSSDKEASQHDAAKIEFDTFRLQVLSGGVTESISWRDFINVPTLKIFGLIF 276
            |..:..|       ....:|..:......|...|:|.:|.         |..::.|.  |.|:
  Rat   218 AMAALRF-------LWGSEEGWEEPPVGAEHQGFQLAMLR---------RPGVHKPL--IIGI-- 262

  Fly   277 VLIICNQLSGSFAIFNYTSHIFAELGNNLDPNTSTIVVGAAQLVGIFSAVVLVDRLGRRVLLLTS 341
            .|::..||||..||..|.:.||.| ....|.:.:::.||..|::....|.:::||.||::||..|
  Rat   263 CLMVFQQLSGVNAIMFYANTIFEE-AKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRKLLLALS 326

  Fly   342 MGGMGLGELAIALLKCFASDEFLNQNG-------------------------WLPLVIMCLVACI 381
                  |.:.:..:..|.:...|.|:|                         ||.:..|||....
  Rat   327 ------GVIMVFSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIAG 385

  Fly   382 ASLGVIALIFIIIIELLPAKIRSIGTSLSMATFSGFIFVALKIYPTMIYDQGLAATMFMSAGMCL 446
            .::|...:.::::.|:.|..|:.:.|.:.:.|.....|:..|.:.:::.........:::|..|:
  Rat   386 FAVGWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAFCI 450

  Fly   447 FGFIVLGLFLPETKGKLM 464
            ...:....|:|||||:.:
  Rat   451 LSVLFTLTFVPETKGRTL 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14606	NP_001334690.1	None
Slc2a8	NP_445946.2	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:10671487	12..13
		MFS	27..470	CDD:421695	124/473 (26%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337818
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850