DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14606 and ITR1

DIOPT Version :9

Sequence 1:	NP_001334690.1	Gene:	CG14606 / 40866	FlyBaseID:	FBgn0037485	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_010785.1	Gene:	ITR1 / 852108	SGDID:	S000002905	Length:	584	Species:	Saccharomyces cerevisiae

Alignment Length:	488	Identity:	123/488 - (25%)
Similarity:	205/488 - (42%)	Gaps:	82/488 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 FIATMT--VHIMTLTHGIAVGWLSPSLRLLASDESPLGDPLTITQASWVGSLIGLGSLTGNIIFG 82
            ||.|:|  ..|.....|...|::|.:|..:.:|..  ...||..:...|.:...||:|..:|..|
Yeast    85 FIITLTFVASISGFMFGYDTGYISSALISIGTDLD--HKVLTYGEKEIVTAATSLGALITSIFAG 147

  Fly    83 LLLDRLGRKVCMYFLAIPNMIYWILIYSAQDVTYLYAGRFLAGMSGGGCYVVLPIFIAEIADNSV 147
            ...|..|||.|:....:..:|..||..||.....:..||.:.|...|...::.|:||:|||...:
Yeast   148 TAADIFGRKRCLMGSNLMFVIGAILQVSAHTFWQMAVGRLIMGFGVGIGSLIAPLFISEIAPKMI 212

  Fly   148 RGALSSMAMMYVSIGMMVGFTLASYLPYY-----------LMPCIIVALPVVFMLSVIGLSETPQ 201
            ||.|:.:..::::.|.:|.:...:.|.|.           |:|..:....:.|      |.:||:
Yeast   213 RGRLTVINSLWLTGGQLVAYGCGAGLNYVNNGWRILVGLSLIPTAVQFTCLCF------LPDTPR 271

  Fly   202 YLLRRG---RDDQAEKSFYFYKNLTPPTSSDKEASQHDAAKIEFDTFRLQVLSGGVTESISW--- 260
            |.:.:|   |..:..|..|        |.:.:|..:....  |..|....:....|.|.: |
Yeast   272 YYVMKGDLARATEVLKRSY--------TDTSEEIIERKVE--ELVTLNQSIPGKNVPEKV-WNTI 325

  Fly   261 RDFINVPTLKIFGLIFVLIIC-----NQLSGSFAIFNYTSHIFAELGNNLDPNTSTIVVGA---A 317
            ::...||:    .|..::|.|     .|.:|..::..::..||..:|.......|.||.|.   .
Yeast   326 KELHTVPS----NLRALIIGCGLQAIQQFTGWNSLMYFSGTIFETVGFKNSSAVSIIVSGTNFIF 386

  Fly   318 QLVGIFSAVVLVDRLGRRVLLLTSMGGMGLGELAIALLKCFASDEFL--NQNGWLPLVIMCLVAC 380
            .||..||    :|::|||.:||..:.||     .:||:.|..:..||  ..:|.:.:|:.   :.
Yeast   387 TLVAFFS----IDKIGRRTILLIGLPGM-----TMALVVCSIAFHFLGIKFDGAVAVVVS---SG 439

  Fly   381 IASLGVIALIFIIII----------------ELLPAKIRSIGTSLSMAT-FSGFIFVALKIYPTM 428
            .:|.|::.::|||:.                ||.|..:|.||||.:.|| ::|.:.:| ..:.||
Yeast   440 FSSWGIVIIVFIIVFAAFYALGIGTVPWQQSELFPQNVRGIGTSYATATNWAGSLVIA-STFLTM 503

  Fly   429 IYDQGLAATMFMSAGMCLFGFIVLGLFLPETKG 461
            :.:...|.|....||:.....|......||..|
Yeast   504 LQNITPAGTFAFFAGLSCLSTIFCYFCYPELSG 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14606	NP_001334690.1	None
ITR1	NP_010785.1	MFS_HMIT_like	92..533	CDD:340918	116/476 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53651
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750