DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14606 and SLC2A11

DIOPT Version :9

Sequence 1:	NP_001334690.1	Gene:	CG14606 / 40866	FlyBaseID:	FBgn0037485	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_001269793.1	Gene:	SLC2A11 / 66035	HGNCID:	14239	Length:	535	Species:	Homo sapiens

Alignment Length:	511	Identity:	110/511 - (21%)
Similarity:	177/511 - (34%)	Gaps:	175/511 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FSVRYRWQFIATMTVHIMTLTHGIAVGWLSPSLRLLASDESPLGDPLTITQASWVGSLIGLGSLT 76
            |...|....|...|:||...|:..   |       .|....||.|.|.:...|.:.||..||.|.
Human    33 FQFGYNLSIINAPTLHIQEFTNET---W-------QARTGEPLPDHLVLLMWSLIVSLYPLGGLF 87

  Fly    77 GNIIFGLLLDRLGRKVCMYFLAIPNMIYWI---LIY----SAQDVTYLYAGRFLAGMSGGGCYVV 134
            |.::.|.|...||||..:    :.|.|:.:   :::    .|.....:..||.|.|::.|....:
Human    88 GALLAGPLAITLGRKKSL----LVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNI 148

  Fly   135 LPIFIAEIADNSVRGALSSMAMMYVSIGMMVGFTLA--------SYLPYYLMPCII------VAL 185
            .|:::.|.|...:|||::..:.::.::|:::|..:.        ...|..|..|::      .:|
Human   149 QPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGLRELLGGPQAWPLLLASCLVPGALQLASL 213

  Fly   186 PVVFMLSVIGLSETPQYLL---------------RRGRDDQAEKSFYFYKNLTPPTSSDKEASQH 235
            |:        |.|:|:|||               .||..|.|.:        ......::.|.|.
Human   214 PL--------LPESPRYLLIDCGDTEACLAALRRLRGSGDLAGE--------LEELEEERAACQG 262

  Fly   236 DAAKIEFDTFRLQVLSGGVTESISWRDFINVPTLKIFGLIFVLIICNQLSGSFAIFNYTSHIFAE 300
            ..|:..::.|:.:.|...||.                  :.||....:|.|:.:::.|.|.:|.:
Human   263 CRARRPWELFQHRALRRQVTS------------------LVVLGSAMELCGNDSVYAYASSVFRK 309

  Fly   301 LGNNLDPNTSTIVVGAAQLVGIFSAVVLVDRLGRRVLLLTSMGGMGLGELAIALLKCFASDEFLN 365
            .|           |..|:   |..|::                |.|..||..|::.....||
Human   310 AG-----------VPEAK---IQYAII----------------GTGSCELLTAVVSVAGVDE--- 341

  Fly   366 QNGW-------------------LPLVIMCLVACIASLGVIALIFIIIIELLPAKIRSIGTSLSM 411
              ||                   .|..:...:|||       ..||:...:.||.:..
Human   342 --GWGVQAGLTSTSPPPRPRQSSFPWTLYLAMACI-------FAFILSFGIGPAGVTG------- 390

  Fly   412 ATFSGFIFVALKIYPTMIYDQGL--AATMFMSAGMCL--------FGFI-VLGLFL 456
                        |..|.::||..  ||.|...|.|.:        |.|| |||.||
Human   391 ------------ILATELFDQMARPAACMVCGALMWIMLILVGLGFPFIMVLGSFL 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14606	NP_001334690.1	None
SLC2A11	NP_001269793.1	Sugar_tr	22..428	CDD:278511	104/503 (21%)
SLC2A11	NP_001269793.1	MFS	68..>217	CDD:119392	35/160 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840