DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14606 and SLC2A4

DIOPT Version :9

Sequence 1:	NP_001334690.1	Gene:	CG14606 / 40866	FlyBaseID:	FBgn0037485	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_001033.1	Gene:	SLC2A4 / 6517	HGNCID:	11009	Length:	509	Species:	Homo sapiens

Alignment Length:	538	Identity:	124/538 - (23%)
Similarity:	212/538 - (39%)	Gaps:	159/538 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PSQKLSVFSVRYRWQFIATMTVHIMTLTHGIAVGWLSPSLRLL--ASDESPLG----------DP 57
            |.|:::...|      :|..:..:.:|..|..:|.::...:::  :.:|:.||          .|
Human    16 PQQRVTGTLV------LAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPP 74

  Fly    58 LTITQASWVGS--LIGLGSLTGNIIFGLLLDRLGRKVCMY---FLAIPNMIYWILIYSAQDVTYL 117
            .|:| ..|..|  :..:|.:..:.:.|::...||||..|.   .||:.......|..:|.....|
Human    75 GTLT-TLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEML 138

  Fly   118 YAGRFLAGMSGGGCYVVLPIFIAEIADNSVRGALSSMAMMYVSIGMMVGFTL--------ASYLP 174
            ..||||.|...|....::|:::.|||...:||||.::..:.:.||:::...|        ||..|
Human   139 ILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWP 203

  Fly   175 YYLMPCIIVALPVVFMLSVIGL-SETPQYLLRRGRDDQAEKSFYFYKNLTPPTSSDKEASQHDAA 238
            ..|.   :..||.:..|.::.. .|:|:||             |..:||..|....
Human   204 LLLG---LTVLPALLQLVLLPFCPESPRYL-------------YIIQNLEGPARKS--------- 243

  Fly   239 KIEFDTFRLQVLSGGVTESISWRDFINV-----------------PTLKIFG---------LIFV 277
                    |:.|:|       |.|...|                 ..|::.|         :..|
Human   244 --------LKRLTG-------WADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVV 293

  Fly   278 LIICNQLSGSFAIFNYTSHIFAELGNNLDPNTSTIVVGAAQLVGIFSAVVLVDRLGRRVLLLTSM 342
            |.:..||||..|:|.|::.||...|.. .|..:||..|....|....:|:||:|.|||.|.|..:
Human   294 LQLSQQLSGINAVFYYSTSIFETAGVG-QPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGL 357

  Fly   343 GGMGLGELAIALLKCFASDEFLNQNGWLPLVIMCLVACIASLGVIALI-FIIIIELLP------- 399
            .||    ...|:|...|            |:::..|..::.:.::|:. |:...|:.|
Human   358 AGM----CGCAILMTVA------------LLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFI 406

  Fly   400 -AKIRSIG---TSLSMATFS----------GFIFVALKIYPTMIYDQGLAATMFMSAGMCLFGFI 450
             |::.|.|   .::::|.||          ||.:||          :.:...:|:     ||..:
Human   407 VAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVA----------EAMGPYVFL-----LFAVL 456

  Fly   451 VLGLFL------PETKGK 462
            :||.|:      |||:|:
Human   457 LLGFFIFTFLRVPETRGR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14606	NP_001334690.1	None
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269\|PubMed:16647043	7..13
		Sugar_tr	27..483	CDD:306568	121/521 (23%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		4/5 (80%)
		Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:8300557	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144116
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840