DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14606 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_001334690.1	Gene:	CG14606 / 40866	FlyBaseID:	FBgn0037485	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_062361.1	Gene:	Slc2a8 / 56017	MGIID:	1860103	Length:	477	Species:	Mus musculus

Alignment Length:	477	Identity:	124/477 - (25%)
Similarity:	217/477 - (45%)	Gaps:	58/477 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RYRWQFIATMTVHIMTLTHGIAVGWLS---PSLRLLASDESPLGDPLTITQASWVGSLIGLGSLT 76
            |.|..|:|:....:..|:.|.|:|:.|   ||||..|.....|||    ..|||.|:::.||:..
Mouse    22 RGRRVFLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGD----NAASWFGAVVTLGAAA 82

  Fly    77 GNIIFGLLLDRLGRKVCMYFLAIPNMIYWILIYSAQDVTYLYAGRFLAGMSGGGCYVVLPIFIAE 141
            |.|:.|.||||.|||:.:....:|.:..:.:|.:|:||..|..||.|.|::.|...:|.|::|:|
Mouse    83 GGILGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISE 147

  Fly   142 IADNSVRGALSSMAMMYVSIGMMVGFTLASYLPYYLMPCIIVALPVVFMLSVIGLSETPQYLLRR 206
            ||..:|||.|.|...:.|..|:::.:.....|.:..:..:....|.:.:|.:..:.|||::||.:
Mouse   148 IAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQ 212

  Fly   207 GRDDQAEKSFYFYKNLTPPTSSDKEASQHDAAKIEFDTFRLQVLSGGVTESISWRDFINVPTLKI 271
            .:..:|..:..|       ....:|..:......|...|:|.:|.         |..|..|.  |
Mouse   213 HQYQEAMAALRF-------LWGSEEGWEEPPVGAEHQGFQLALLR---------RPGIYKPL--I 259

  Fly   272 FGLIFVLIICNQLSGSFAIFNYTSHIFAELGNNLDPNTSTIVVGAAQLVGIFSAVVLVDRLGRRV 336
            .|:  .|::..||||..||..|.:.||.| ....|.:.:::.||..|::....|.:::||.|||:
Mouse   260 IGI--SLMVFQQLSGVNAIMFYANSIFEE-AKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRRL 321

  Fly   337 LLLTSMGGMGLGELAIALLKCFASDEFLNQN------------------------GWLPLVIMCL 377
            ||..|      |.:.:..:..|.:...|.|:                        .||.:..|||
Mouse   322 LLALS------GVIMVFSMSAFGTYFKLTQSLPSNSSHVGLVPIAAEPVDVQVGLAWLAVGSMCL 380

  Fly   378 VACIASLGVIALIFIIIIELLPAKIRSIGTSLSMATFSGFIFVALKIYPTMIYDQGLAATMFMSA 442
            .....::|...:.::::.|:.|..::.:.|.:.:.|.....|:..|.:.:::.........:::|
Mouse   381 FIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWFMAFLVTKEFSSVMEMLRPYGAFWLTA 445

  Fly   443 GMCLFGFIVLGLFLPETKGKLM 464
            ..|....:.....:|||||:.:
Mouse   446 AFCALSVLFTLTVVPETKGRTL 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14606	NP_001334690.1	None
Slc2a8	NP_062361.1	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:16723738	12..13
		Sugar_tr	29..474	CDD:278511	121/470 (26%)
		MFS	31..459	CDD:119392	115/458 (25%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840