DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14606 and Slc2a4

DIOPT Version :9

Sequence 1:	NP_001334690.1	Gene:	CG14606 / 40866	FlyBaseID:	FBgn0037485	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_036883.1	Gene:	Slc2a4 / 25139	RGDID:	2711	Length:	509	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	134/522 - (25%)
Similarity:	211/522 - (40%)	Gaps:	127/522 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PSQKLSVFSVRYRWQFIATMTVHIMTLTHGIAVGWLSPSLRLLASD--------ESPLGDPLTIT 61
            |.|:::...|      :|..:..:.:|..|..:|.::...:::...        :.| |.|.:|.
  Rat    16 PQQRVTGTLV------LAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGP-GGPDSIP 73

  Fly    62 QAS----WVGS--LIGLGSLTGNIIFGLLLDRLGRKVCMY---FLAIPNMIYWILIYSAQDVTYL 117
            |.:    |..|  :..:|.:..:.:.|::...||||..|.   .||:.......|..:|.....|
  Rat    74 QGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEIL 138

  Fly   118 YAGRFLAGMSGGGCYVVLPIFIAEIADNSVRGALSSMAMMYVSIGMMVGFTL--------ASYLP 174
            ..||||.|...|....::|:::.|||...:||||.::..:.:.||::|...|        |:..|
  Rat   139 ILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWP 203

  Fly   175 YYLMPCIIVALPVVFMLSVIGL-SETPQYL-LRRGRDDQAEKSFYFYKNLTP-PTSSDKEASQHD 236
            ..|   .|..||.:..|.::.. .|:|:|| :.|..:..|.||.   |.||. ...||..|...|
  Rat   204 LLL---AITVLPALLQLLLLPFCPESPRYLYIIRNLEGPARKSL---KRLTGWADVSDALAELKD 262

  Fly   237 -AAKIEFDTFRLQVLSGGVTESISWRDFINVPTLKIFG---------LIFVLIICNQLSGSFAIF 291
             ..|:|    |.:.||                .|::.|         :..||.:..||||..|:|
  Rat   263 EKRKLE----RERPLS----------------LLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVF 307

  Fly   292 NYTSHIFAELGNNLDPNTSTIVVGAAQLVGIFSAVVLVDRLGRRVLLLTSMGGMG----LGELAI 352
            .|::.|| ||.....|..:||..|....|....:|:||:|.|||.|.|..:.||.    |..:|:
  Rat   308 YYSTSIF-ELAGVEQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVAL 371

  Fly   353 ALLKCFASDEFLNQNGWLPLVIMCLVACIASLGVIALI--------FIIIIELL-----PAKIRS 404
            .||:...|              |..|:.:|..|.:|..        :.|:.||.     ||.:..
  Rat   372 LLLERVPS--------------MSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAV 422

  Fly   405 IGTSLSMATF---SGFIFVALKIYPTMIYDQGLAATMFMSAGMCLFGFIVLGLFL------PETK 460
            .|.|.....|   .||.:||          ..:...:|:     ||..::||.|:      |||:
  Rat   423 AGFSNWTCNFIVGMGFQYVA----------DAMGPYVFL-----LFAVLLLGFFIFTFLRVPETR 472

  Fly   461 GK 462
            |:
  Rat   473 GR 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14606	NP_001334690.1	None
Slc2a4	NP_036883.1	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13
		Sugar_tr	27..483	CDD:278511	131/505 (26%)
		MFS	78..447	CDD:119392	112/419 (27%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		4/5 (80%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840