DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14606 and SLC2A6

DIOPT Version :9

Sequence 1:	NP_001334690.1	Gene:	CG14606 / 40866	FlyBaseID:	FBgn0037485	Length:	466	Species:	Drosophila melanogaster
Sequence 2:	NP_060055.2	Gene:	SLC2A6 / 11182	HGNCID:	11011	Length:	507	Species:	Homo sapiens

Alignment Length:	485	Identity:	127/485 - (26%)
Similarity:	216/485 - (44%)	Gaps:	46/485 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PSQKLSVFSVRYRWQFIATMTVHIMTLTHGIAVGWLSPSLRLLASDESPLGDP---LTITQASWV 66
            |..:..|.:::.:..|:||....:...:.|.|:.:.||.:..|   |..| ||   ||.:||||.
Human    24 PGDRARVGTLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPAL---ERSL-DPDLHLTKSQASWF 84

  Fly    67 GSLIGLGSLTGNIIFGLLLDRLGRKVCMYFLAIPNMIYWILIYSAQDVTYLYAGRFLAGMSGGGC 131
            ||:..||:..|.:...:|.|.||||:.:.|.|:|:...:.|:..|..:..|..||.|.|.:||..
Human    85 GSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLT 149

  Fly   132 YVVLPIFIAEIADNSVRGALSSMAMMYVSIGMMVGFTLASYLPYYLMPCIIVALPVVFMLSVIG- 195
            ...:|::::|||...|||||.:...:....|.:..:.|...||:..: .:....||:.|:.::.
Human   150 AACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWL-AVAGEAPVLIMILLLSF 213

  Fly   196 LSETPQYLLRRGRDDQAEKSFYFYKNLTPPTSSDKEASQHDAAKIEFDTFRLQVLSGGVTESISW 260
            :..:|::||.||||::|.::..:.:........:.|..|        |..|.|      :..:||
Human   214 MPNSPRFLLSRGRDEEALRALAWLRGTDVDVHWEFEQIQ--------DNVRRQ------SSRVSW 264

  Fly   261 RDFINVPTLKIFGLIFVLIICNQLSGSFAIFNYTSHIFAELGNNLDPNTSTIVVGAAQLVGIFSA 325
            .:.......:...:..::.:..||:|...|..|...||......|.|.....:|||.:|:.:..|
Human   265 AEARAPHVCRPITVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIA 329

  Fly   326 VVLVDRLGRRVLLLTSMGGMGLGELAIALLKCFA-------SDEFLNQNGW--------LPLVIM 375
            .:.:|..||:|||..|...|....|.:.|...|.       |...|....|        .|...:
Human   330 ALTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAPAGYL 394

  Fly   376 CLVACIASL--------GVIALIFIIIIELLPAKIRSIGTSLSMATFSGFIFVALKIYPTMIYDQ 432
            .||..:|::        |...:.::::.|:||.:.|.:.:.|.:.......||..|.:..::...
Human   395 TLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTF 459

  Fly   433 GLAATMFMSAGMCLFGFIVLGLFLPETKGK 462
            ||....|..|.:||...:..|..:|||||:
Human   460 GLQVPFFFFAAICLVSLVFTGCCVPETKGR 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14606	NP_001334690.1	None
SLC2A6	NP_060055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		1/3 (33%)
		Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS_GLUT6_Class3	39..493	CDD:340992	125/470 (27%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	286..292		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144137
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53651
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860