DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lap and SNAP91

DIOPT Version :9

Sequence 1:	NP_001163538.1	Gene:	lap / 40863	FlyBaseID:	FBgn0086372	Length:	788	Species:	Drosophila melanogaster
Sequence 2:	NP_001229721.1	Gene:	SNAP91 / 9892	HGNCID:	14986	Length:	907	Species:	Homo sapiens

Alignment Length:	969	Identity:	354/969 - (36%)
Similarity:	447/969 - (46%)	Gaps:	283/969 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MAGQTINDRLLAARHSLAGQGLAKSVCKATTEECIGPKKKHLDYLVHCTNEPNVSIPHLANLLIE 67
            |:|||:.||:.||::|:.|..:|::||||||.|.:||||||||||:..|||.||:||.:|:.|.|
Human     1 MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFE 65

  Fly    68 RSQNANWVVVYKSLITTHHLMAYGNERFMQYLASSNSTFNLSSFLDKGTVQDGGMGVPGGRMGYD 132
            |:.|::||||:|:|:||||||.:|||||:|||||.|:.||||:||||           .|..|||
Human    66 RATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDK-----------SGSHGYD 119

  Fly   133 MSPFIRRYAKYLNEKSLSYRAMAFDFCKVKRGKEEGSLRSMNAEKLLKTLPVLQAQLDALLEFDC 197
            ||.|||||::|||||:.|||.|||||.:||:| .:|.:|:|..|||||::|:||.|:|||||||.
Human   120 MSTFIRRYSRYLNEKAFSYRQMAFDFARVKKG-ADGVMRTMAPEKLLKSMPILQGQIDALLEFDV 183

  Fly   198 QSNDLSNGVINMSFMLLFRDLIRLFACYNDGIINLLEKYFDMNKKHARDALDLYKKFLVRMDRVG 262
            ..|:|:|||||.:|||||:|||:||||||||:||||||:|:|.|...:|||::||:||.||.||.
Human   184 HPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVS 248

  Fly   263 EFLKVAENVGIDKGDIPDLTKAPSSLLDALEQHLATLEGRKV-----SAANTPTQSSSNQRNVKS 322
            |||||||.||||||||||||:|||||::.|||||.||||:|.     |.|.:|...||....|.|
Human   249 EFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTS 313

  Fly   323 AVSALSSTSSAFGTAAASSKFDTTNGIDEQLKAQVLAEEEAAMNQYKSKVSSPT-------SSGA 380
            ..|..:.|            .||:..:|      :.|...||:....||.||..       |||.
Human   314 PNSTPAKT------------IDTSPPVD------LFATASAAVPVSTSKPSSDLLDLQPDFSSGG 360

  Fly   381 AGASAALTNP-------------------FLSSPPA-AQAGQPI--------------------- 404
            |.|:||...|                   .|||.|: ||...|.
Human   361 AAAAAAPAPPPPAGGATAWGDLLGEDSLAALSSVPSEAQISDPFAPEPTPPTTTAEIATASASAS 425

  Fly   405 -----------VDLFG---------AASAQPAAAAAAT----KASDDLLQLGNPFA--------- 436
                       |||||         |.:|...|||.||    .|:.|.....:|||
Human   426 TTTTVTAVTAEVDLFGDAFAASPGEAPAASEGAAAPATPTPVAAALDACSGNDPFAPSEGSAEAA 490

  Fly   437 ---DMF----------------------------DASGGGAAAVGATGFNGA-----SVSSAAAT 465
               |:|                            .|....|||...|....|     :.|:|.||
Human   491 PELDLFAMKPPETSVPVVTPTASTAPPVPATAPSPAPAVAAAAAATTAATAAATTTTTTSAATAT 555

  Fly   466 NAFVSDSNFSSVFGNTEPAASTSLPN--PFFDDMSL------PQ--IPLPAESV----------A 510
            .|..:...|..:|.:|...|:...|:  |..|..|.      ||  .|:|..|:          |
Human   556 TAPPALDIFGDLFESTPEVAAAPKPDAAPSIDLFSTDAFSSPPQGASPVPESSLTADLLSVDAFA 620

  Fly   511 AP-------------------FGNNINFMDQQLQQQQQAALYVQQQQQQQL------QLQQQQHR 550
            ||                   ||:.......:.|...|||  ........|      ........
Human   621 APSPATTASPAKVDSSGVIDLFGDAFGSSASEPQPASQAA--SSSSASADLLAGFGGSFMAPSPS 683

  Fly   551 PQLPQQQAILTPSMSAA-----------QFPPG-FDALGDVLKPASASNNSNQMNVVAAGYSSNS 603
            |..|.|..:|.|:..||           .|.|. ||.|||:|.|..|          .||..:..
Human   684 PVTPAQNNLLQPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMA----------PAGQPAPV 738

  Fly   604 SSILALQQQQHQQHQQQHQHQLNQQQQQQPPAGTGKIITGDLDSSLMSLVDNLNINKTASAK-PV 667
            |.:                       ...|.....|.:..||||||.|||.||.|:.|.:.| .:
Human   739 SMV-----------------------PPSPAMAASKALGSDLDSSLASLVGNLGISGTTTKKGDL 780

  Fly   668 QWNSPKNTAKPGANWTPQPMAATTGAGYRPMAHGMTVSPAPITINHPYIHASYPVMPNYMQGMPV 732
            |||:.:.....||||.|:...||..||..|        .||:....|...:..||     .|.|.
Human   781 QWNAGEKKLTGGANWQPKVAPATWSAGVPP--------SAPLQGAVPPTSSVPPV-----AGAPS 832

  Fly   733 MGQPSMMGGQAAA----PLTGVQPTMMAAPHSNATGIMQPIQPTQNGSNKGVPLDPFGA 787
            :|||....|...|    |:...||.|.|.|      :|:|               ||||
Human   833 VGQPGAGFGMPPAGTGMPMMPQQPVMFAQP------MMRP---------------PFGA 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lap	NP_001163538.1	ANTH	21..298	CDD:284961	180/276 (65%)
lap	NP_001163538.1	Amelogenin	694..>773	CDD:197891	22/82 (27%)
SNAP91	NP_001229721.1	ANTH	21..284	CDD:311541	179/274 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..326		15/52 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..380		12/37 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..414		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..525		0/19 (0%)
		Atrophin-1	<595..897	CDD:331285	88/345 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	867..907		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	382	1.000	Domainoid score	I836
eggNOG	1	0.900	-	-		E1_KOG0251
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1686
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56288
OrthoDB	1	1.010	-	-		D1592722at2759
OrthoFinder	1	1.000	-	-		FOG0001047
OrthoInspector	1	1.000	-	-		otm40531
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22951
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X389
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.940