DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lap and Picalm

DIOPT Version :9

Sequence 1:	NP_001163538.1	Gene:	lap / 40863	FlyBaseID:	FBgn0086372	Length:	788	Species:	Drosophila melanogaster
Sequence 2:	XP_006229731.1	Gene:	Picalm / 89816	RGDID:	621054	Length:	686	Species:	Rattus norvegicus

Alignment Length:	828	Identity:	320/828 - (38%)
Similarity:	424/828 - (51%)	Gaps:	190/828 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MAGQTINDRLLAARHSLAGQGLAKSVCKATTEECIGPKKKHLDYLVHCTNEPNVSIPHLANLLIE 67
            |:||::.||:.||:||:.|..::|:||||||.|.:||||||||||:.||||.||:||.||:.|.|
  Rat     1 MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFE 65

  Fly    68 RSQNANWVVVYKSLITTHHLMAYGNERFMQYLASSNSTFNLSSFLDKGTVQDGGMGVPGGRMGYD 132
            |:.|::||||:||||||||||.||||||:|||||.|:.||||:||||           .|..|||
  Rat    66 RTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDK-----------SGLQGYD 119

  Fly   133 MSPFIRRYAKYLNEKSLSYRAMAFDFCKVKRGKEEGSLRSMNAEKLLKTLPVLQAQLDALLEFDC 197
            ||.|||||::|||||::|||.:||||.||||| .:|.:|:||.||||||:|::|.|:||||:|:.
  Rat   120 MSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRG-ADGVMRTMNTEKLLKTVPIIQNQMDALLDFNV 183

  Fly   198 QSNDLSNGVINMSFMLLFRDLIRLFACYNDGIINLLEKYFDMNKKHARDALDLYKKFLVRMDRVG 262
            .||:|:|||||.:|||||:|.|||||.||:||||||||||||.|...::.||:|||||.||.|:.
  Rat   184 NSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRIS 248

  Fly   263 EFLKVAENVGIDKGDIPDLTKAPSSLLDALEQHLATLEGRKVSAANTPTQSSSNQRNVKSAVSAL 327
            |||||||.||||:||||||::||||||||||||||:|||:|:.    .:.::|....:.:|||:|
  Rat   249 EFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIK----DSTAASRATTLSNAVSSL 309

  Fly   328 SSTSSAFGTAAASSKFDTTNGIDEQLKAQVLAEEEAAMNQYKSK---------------VSSPTS 377
            :||..:.            ..:||:.|...|.||:|.:...|.:               .:||.|
  Rat   310 ASTGLSL------------TKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVS 362

  Fly   378 SGAAGASAALTNPFLSSPPAAQAGQPIVDLFGAASAQPAAAAAATKASDDLLQLGNPFADMFDAS 442
            :.|.|...|                |.:|:|    :.|:::.:.:|..:|||.|..|
  Rat   363 TSAGGIMTA----------------PAIDIF----STPSSSNSTSKLPNDLLDLQQP-------- 399

  Fly   443 GGGAAAVGATGFNGASVSSAAATNAFVSDSNFSSVFGNTEPAASTSLP--NPFFDDMSLPQIPLP 505
                     |........|||...|    |.:...|..|..|...::|  |||....| ..:.||
  Rat   400 ---------TFHPSVHAMSAAPQVA----STWGDPFSATLDAVDDAIPSLNPFLTKSS-GDVHLP 450

  Fly   506 AESVAAPFGNN-------INFMDQQL-QQQQQAALYVQQQQQQQLQLQQQQHRPQLPQQQAILTP 562
            ..|..:.|...       :.|....: |....|.|.|.                   .:......
  Rat   451 ISSDVSTFTTRTPTHEMFVGFSPSPVTQPHPSAGLNVD-------------------FESVFGNK 496

  Fly   563 SMSAAQFPPGFDALGDVLKPASASNNSNQMNVVAAGYSSNSSSILALQQQQHQQHQQQHQHQLNQ 627
            |.:.|....|||.||.:|||..||.|
  Rat   497 STNVAVDSGGFDELGGLLKPTVASQN--------------------------------------- 522

  Fly   628 QQQQQPPA--GTGKIITGDLDSSLMSLVDNLNINKTASAKPVQWNSP-KNTAKPGANWTPQ--PM 687
              |..|.|  ...|:::.||||||.:||.||.|....:...|.|:.| :.....|:||.|:  |.
  Rat   523 --QSLPVAKLAPNKLVSDDLDSSLANLVGNLGIGNGTTKNDVSWSQPGEKKLTGGSNWQPKVAPT 585

  Fly   688 AATTGA--------GYRP--MAHGMTVSPAPITINHPYIHASYPVM--PNYMQGMPVMGQPSMMG 740
            .|.:.|        .|.|  ||:..|.....|....|....|.|||  |..:...|||..|:..|
  Rat   586 TAWSAATMNGMHFPQYAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFG 650

  Fly   741 GQAAAPLTGVQPTMMAAPHSNATGIMQPIQPTQNGSNKGVPLDPFGAL 788
                 |:.|.|   ::|..|          |:::..::....|||..|
  Rat   651 -----PVPGAQ---LSAASS----------PSRHSPHRAAGKDPFAEL 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lap	NP_001163538.1	ANTH	21..298	CDD:284961	187/276 (68%)
lap	NP_001163538.1	Amelogenin	694..>773	CDD:197891	23/82 (28%)
Picalm	XP_006229731.1	ANTH	19..282	CDD:284961	185/274 (68%)
Picalm	XP_006229731.1	DASH_Spc19	<265..344	CDD:285487	36/94 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338081
Domainoid	1	1.000	382	1.000	Domainoid score	I796
eggNOG	1	0.900	-	-		E1_KOG0251
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111783
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1624
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1592722at2759
OrthoFinder	1	1.000	-	-		FOG0001047
OrthoInspector	1	1.000	-	-		otm44671
orthoMCL	1	0.900	-	-		OOG6_102822
Panther	1	1.100	-	-	LDO	PTHR22951
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X389
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800