DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lap and YAP1801

DIOPT Version :9

Sequence 1:	NP_001163538.1	Gene:	lap / 40863	FlyBaseID:	FBgn0086372	Length:	788	Species:	Drosophila melanogaster
Sequence 2:	NP_012031.1	Gene:	YAP1801 / 856566	SGDID:	S000001204	Length:	637	Species:	Saccharomyces cerevisiae

Alignment Length:	740	Identity:	192/740 - (25%)
Similarity:	281/740 - (37%)	Gaps:	200/740 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KSVCKATTEECIGPKKKHLD-YLVHCTNEPNVSIPHLANLLIERSQNANWVVVYKSLITTHHLMA 89
            |.|..||..:...||:|:|| .|:..:||.:  ...:...|..|..:..|.:|||||:..|.::.
Yeast     6 KLVKGATKIKSAPPKQKYLDPILLGTSNEED--FYEIVKGLDSRINDTAWTIVYKSLLVVHLMIR 68

  Fly    90 YGNERF-MQYLASSNSTFNLSSFLDKGTVQDGGMGVPGGRMGYDMSPFIRRYAKYLNEKSLSYRA 153
            .|::.. ::|.:.:...|::.:.          .|..|...| ||.. :.||..||       :.
Yeast    69 EGSKDVALRYYSRNLEFFDIENI----------RGSNGSASG-DMRA-LDRYDNYL-------KV 114

  Fly   154 MAFDFCKVKR-----------------GKEEGSLRSMNAEKLLKTLPVLQAQLDALLEFDCQSND 201
            ...:|.|:|:                 |.......|:|.  .|..:..|:.|:.||::......|
Yeast   115 RCREFGKIKKDYVRDGYRTLKLNSGNYGSSRNKQHSINI--ALDHVESLEVQIQALIKNKYTQYD 177

  Fly   202 LSNGVINMSFMLLFRDLIRLFACYNDGIINLLEKYFDMNKKHARDALDLYKKFLVRMDRVGEFLK 266
            |||.:|...|.||.:||:.|:...|:|||.|||.:|:::..:|...|||||.|:...:.|..:||
Yeast   178 LSNELIIFGFKLLIQDLLALYNALNEGIITLLESFFELSHHNAERTLDLYKTFVDLTEHVVRYLK 242

  Fly   267 VAENVGIDKGDIPDLTKAPSSLLDALEQHLATLEGRKVSAANTPTQSSSNQRNVKSAVSALSSTS 331
            ..:..|:   .||.:....:.|:.:||:||  :|..|......|..||.               .
Yeast   243 SGKTAGL---KIPVIKHITTKLVRSLEEHL--IEDDKTHNTFVPVDSSQ---------------G 287

  Fly   332 SAFGTAAASSKFDTTNGIDEQ---LKAQVLAEEEAAMNQYKSKVSSPTSSGAAGASAAL------ 387
            ||....|.|:..:....|.||   |:|| |..|:.|::...:.|::..|....|..:::
Yeast   288 SAGAVVAKSTAQERLEQIREQKRILEAQ-LKNEQVAISPALTTVTAAQSYNPFGTDSSMHTNIPM 351

  Fly   388 ----------TNPFLSSPPAAQAGQPIVDLFGAASAQPAAAAAATKASDDLLQLGNPFADMFDAS 442
                      .|||:|..      ||.|.....|..:||.......|:.......||..|    :
Yeast   352 AVANQTQQIANNPFVSQT------QPQVMNTPTAHTEPANLNVPEYAAVQHTVNFNPVQD----A 406

  Fly   443 GGGAAAVG-------------ATGFNGASVS--SAAATNAFVSDSNFSS------------VFGN 480
            |..|...|             ..||.|.|||  :.||:|..||.|...|            ..||
Yeast   407 GVSAQQTGYYSINNHLTPTFTGAGFGGYSVSQDTTAASNQQVSHSQTGSNNPFALHNAATIATGN 471

  Fly   481 TEPAASTSLPNPF----FDDMSLPQIPLPAESVAAPFGNNINFMDQQLQQQQQAALYVQQQQQQQ 541
              ||....|.|||    ||:.: ..:||..:.::.||.|                   |...|||
Yeast   472 --PAHENVLNNPFSRPNFDEQN-TNMPLQQQIISNPFQN-------------------QTYNQQQ 514

  Fly   542 LQLQQQQHRPQLPQQQAILTPS--MSAAQFPPGFDALGDVLKPASASNNSNQMNVVAAGYSSNSS 604
            .   |||..|.......:.||:  ..:...|..||.:                 ...|.|:.|.
Yeast   515 F---QQQKMPLSSINSVMTTPTSMQGSMNIPQRFDKM-----------------EFQAHYTQNH- 558

  Fly   605 SILALQQQQHQQHQQQHQHQLNQQQQQQP------PAGTGKIITGDLDSSLMSLVDNLNINKTAS 663
                |||||.||.|||      |||||||      ||..|.               |...|.|.:
Yeast   559 ----LQQQQQQQQQQQ------QQQQQQPQQGYYVPATAGA---------------NPVTNITGT 598

  Fly   664 AKPVQWN-SPKNTAKPGANWTPQPM 687
            .:|..:. .|:...:|..:.|.||:
Yeast   599 VQPQNFPFYPQQQPQPEQSQTQQPV 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lap	NP_001163538.1	ANTH	21..298	CDD:284961	81/290 (28%)
lap	NP_001163538.1	Amelogenin	694..>773	CDD:197891
YAP1801	NP_012031.1	ANTH	3..269	CDD:400137	79/288 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343014
Domainoid	1	1.000	103	1.000	Domainoid score	I1497
eggNOG	1	0.900	-	-		E1_KOG0251
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I1374
Isobase	1	0.950	-	0	Normalized mean entropy	S2368
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001047
OrthoInspector	1	1.000	-	-		otm46569
orthoMCL	1	0.900	-	-		OOG6_102822
Panther	1	1.100	-	-	O	PTHR22951
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2028
SonicParanoid	1	1.000	-	-		X389
TreeFam	1	0.960	-	-
	14	13.730