DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lap and YAP1802

DIOPT Version :9

Sequence 1:	NP_001163538.1	Gene:	lap / 40863	FlyBaseID:	FBgn0086372	Length:	788	Species:	Drosophila melanogaster
Sequence 2:	NP_011757.3	Gene:	YAP1802 / 853157	SGDID:	S000003473	Length:	568	Species:	Saccharomyces cerevisiae

Alignment Length:	640	Identity:	156/640 - (24%)
Similarity:	263/640 - (41%)	Gaps:	118/640 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KSVCKATTEECIGPKKKHLDYLVHCTNEPNVSIPHLANLLIERSQNANWVVVYKSLITTHHLMAY 90
            |.|..||..:...||:|::|.::..|:... .:..:.:.|..|..:..|.:|||:||..|.::..
Yeast     7 KLVKGATKIKMAPPKQKYVDPILSGTSSAR-GLQEITHALDIRLSDTAWTIVYKALIVLHLMIQQ 70

  Fly    91 GNERF-MQYLASSNSTFNLS--SFLDKGTVQDGGMGVPGGRMGYDMSPFIRRYAKYLNEKSLSYR 152
            |.:.. :::.:.:...|.|.  |...|.:..|              ...::||.:||..:...|.
Yeast    71 GEKDVTLRHYSHNLDVFQLRKISHTTKWSSND--------------MRALQRYDEYLKTRCEEYG 121

  Fly   153 AMAFDFCKVKRGK-EEGSLRSMNAEKLLKTLPVLQAQLDALLEFDCQSNDLSNGVINMSFMLLFR 216
            .:..|..:..... :.||...::.::.|..:..|:.|::||:......:||.|.::..:|.||.:
Yeast   122 RLGMDHLRDNYSSLKLGSKNQLSMDEELDHVESLEIQINALIRNKYSVSDLENHLLLYAFQLLVQ 186

  Fly   217 DLIRLFACYNDGIINLLEKYFDMNKKHARDALDLYKKFLVRMDRVGEFLKVAENVGIDKGDIPDL 281
            ||:.|:...|:|:|.|||.:|:::.:||:..|||||.|:...:.|..:||:.:.||:   .||.:
Yeast   187 DLLGLYNALNEGVITLLESFFELSIEHAKRTLDLYKDFVDMTEYVVRYLKIGKAVGL---KIPVI 248

  Fly   282 TKAPSSLLDALEQHLATLEGRKVSAANTPTQSSSNQRNVKSAVSALSSTSSAFGTAAASSKFDTT 346
            ....:.|:::||:||.....|:....:.|.|.       :...:|:|||||....:...:|....
Yeast   249 KHITTKLINSLEEHLREETKRQRGEPSEPQQD-------RKPSTAISSTSSHNNNSNDKNKSIAQ 306

  Fly   347 NGIDEQLKAQVLAEEEAAMNQYKSKVSSPTSSGAA-----GASAALTNPFLSSPP-----AAQAG 401
            ..: ||::.|....|:...||  ..:.|||....|     .....|.|...|..|     .||..
Yeast   307 KKL-EQIREQKRLLEQQLQNQ--QLLISPTVPQDAYNPFGSQQQDLNNDTFSFEPTQPQMTAQVP 368

  Fly   402 QPIVDLFGAASAQPAA---AAAATKASDDLLQ----LGNPFADMFDASGGGAAAVGATGFNGASV 459
            ||..:.|.....|..|   .:|:|......:|    |.|....|:.::.........:||.|
Yeast   369 QPTANPFLIPQQQQQALQLTSASTMPQPSEIQITPNLNNQQTGMYASNLQYTPNFTGSGFGG--- 430

  Fly   460 SSAAATNAFVSDSNFSSVFGNTEPAASTSLPNPFFDDMSLPQIPLPAESVAAPFGNNINFMDQQL 524
                    :.:..|.:.:.|..:| ..|...|||    ||       |::|
Yeast   431 --------YTTTENNAIMTGTLDP-TKTGSNNPF----SL-------ENIA-------------- 461

  Fly   525 QQQQQAALYVQQQQQQQLQ-------LQQQQHRPQLP--------QQQAILTPSMSAAQFPPGFD 574
                      ::||||..|       |||.|..|.|.        |.|.::|..|......|
Yeast   462 ----------REQQQQNFQNSPNPFTLQQAQTTPILAHSQTGNPFQAQNVVTSPMGTYMTNP--- 513

  Fly   575 ALGDVLKPAS--ASNNSNQMNVVAAGYSSNSSSILAL-QQQQHQQHQQQHQHQLN 626
             :...|:.||  |......|.....||....::.:.: ||||.|||||::.:.::
Yeast   514 -VAGQLQYASTGAQQQPQMMQGQQTGYVMVPTAFVPINQQQQQQQHQQENPNLID 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lap	NP_001163538.1	ANTH	21..298	CDD:284961	73/275 (27%)
lap	NP_001163538.1	Amelogenin	694..>773	CDD:197891
YAP1802	NP_011757.3	ANTH	5..263	CDD:400137	71/273 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343013
Domainoid	1	1.000	103	1.000	Domainoid score	I1497
eggNOG	1	0.900	-	-		E1_KOG0251
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I1374
Isobase	1	0.950	-	0	Normalized mean entropy	S2368
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001047
OrthoInspector	1	1.000	-	-		otm46569
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22951
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2028
SonicParanoid	1	1.000	-	-		X389
TreeFam	1	0.960	-	-
	13	12.830