DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lap and snap91b

DIOPT Version :9

Sequence 1:	NP_001163538.1	Gene:	lap / 40863	FlyBaseID:	FBgn0086372	Length:	788	Species:	Drosophila melanogaster
Sequence 2:	XP_009298297.1	Gene:	snap91b / 559029	ZFINID:	ZDB-GENE-041210-81	Length:	628	Species:	Danio rerio

Alignment Length:	807	Identity:	295/807 - (36%)
Similarity:	392/807 - (48%)	Gaps:	229/807 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MAGQTINDRLLAARHSLAGQGLAKSVCKATTEECIGPKKKHLDYLVHCTNEPNVSIPHLANLLIE 67
            |:|||:.||:.||::.|.|..:|::||||||.|.:.||||||:||:..|||.||:||.:|:.|.|
Zfish     1 MSGQTLTDRIAAAQYQLTGSDVARAVCKATTHEVMAPKKKHLEYLISTTNETNVNIPQMADTLFE 65

  Fly    68 RSQNANWVVVYKSLITTHHLMAYGNERFMQYLASSNSTFNLSSFLDKGTVQDGGMGVPGGRMGYD 132
            ||.||:||||:|:|.||||:..||||||:|||||..|.||||:|:||           .|..|||
Zfish    66 RSTNASWVVVFKALTTTHHICIYGNERFIQYLASRTSLFNLSNFIDK-----------TGTHGYD 119

  Fly   133 MSPFIRRYAKYLNEKSLSYRAMAFDFCKVKRGKEEGSLRSMNAEKLLKTLPVLQAQLDALLEFDC 197
            ||.||||||:|||||:.:||||||||.:||:| .||.:|:|..|||||.:|.||.|:|.|||||.
Zfish   120 MSTFIRRYARYLNEKAYAYRAMAFDFTRVKKG-AEGVMRTMATEKLLKAMPALQTQVDTLLEFDV 183

  Fly   198 QSNDLSNGVINMSFMLLFRDLIRLFACYNDGIINLLEKYFDMNKKHARDALDLYKKFLVRMDRVG 262
            ...||:||:||.:|||||:|||:|||.|||||||||||||.|.|...:|:|::|||||.|:.::.
Zfish   184 HPKDLNNGIINAAFMLLFKDLIKLFASYNDGIINLLEKYFKMKKSECKDSLEIYKKFLTRVTKIA 248

  Fly   263 EFLKVAENVGIDKGDIPDLTKAPSSLLDALEQHLATLEGRKVSAANTPTQSSSNQRNVKSAVSAL 327
            ||:|:||.||:||.||||::.||||:|::||.|:.:|||:|  ...:||:.|
Zfish   249 EFMKIAEQVGVDKNDIPDISYAPSSILESLETHMNSLEGKK--GDGSPTKGS------------- 298

  Fly   328 SSTSSAFGTAAASSKFDTTNGIDEQLKAQVLAEEEAAMNQYKSKVSSPTSSGAAGASAALTNPFL 392
                             .||.:                    |..|:|..|||  |...|..|..
Zfish   299 -----------------PTNNV--------------------SPTSTPAKSGA--AVPTLEPPRA 324

  Fly   393 SSPPAAQ-AGQPIVDLFGAASAQPAAAAAATKAS-DDLL--QLGN-----PFADMFDASGGGAAA 448
            .:.|||: |...::||...:|:.|:..|:|...| .|||  ::|:     ...|...|....::|
Zfish   325 DAAPAAETATDSLLDLDPLSSSGPSGGASAAPTSWGDLLGSEIGSLTTETLLPDPTPAVDSASSA 389

  Fly   449 VGATGFNGASVSSAAATNAFVSDSNFSSVFGN----------TEPAASTSLPNPFFDDMSLPQIP 503
            ...|....|:||.|...:|..:.|..:.:.|:          .|..|:.|.|.|..|..:
Zfish   390 TPTTTVAEAAVSLAPPPSAAGASSGSADLLGDMFAAPETAAAAEGGATASTPTPAADGTA----- 449

  Fly   504 LPAESVAAPFGNNINFMDQQLQQQQQAALYVQQQQQQQLQLQQQQHRPQLPQQQAILTPSMSAAQ 568
             ||||..|             .:.:.||                             ..:.....
Zfish   450 -PAESAGA-------------SEAKPAA-----------------------------AAAAGGGD 471

  Fly   569 FPPGFDALGDVLKPASASNNSNQMNVVAAGYSSNSSSILALQQQQHQQHQQQHQHQLNQQQQQQP 633
            ....||.|||||.||.|..        |||.|..:||.:                         .
Zfish   472 LMSAFDGLGDVLMPAMAPQ--------AAGASPMASSPV-------------------------K 503

  Fly   634 PAGTGKIITGDLDSSLMSLVDNLNINKTASAKPVQWNSPKNTAKPGANW---TPQPMAATTGAGY 695
            |.|      |||||::.::..||.:.          |.....|..||||   .|.|
Zfish   504 PMG------GDLDSAMANMAGNLGMG----------NQKPGEAAGGANWQAQVPTP--------- 543

  Fly   696 RPMAHGMTVSPAPITINHPYIHASYPVMPNYMQGM-PVMGQPSMMGGQA--AAPLTGVQPTMMAA 757
               :.|:|::|   ||                 |: ||||.||..|..|  |||:....| ||||
Zfish   544 ---SWGVTMTP---TI-----------------GVCPVMGSPSPFGMPAGGAAPMMPGSP-MMAA 584

  Fly   758 PHSNATGIMQPIQPTQNGSNKGVPLDP 784
                    .||::|.......|.|:.|
Zfish   585 --------QQPVRPQFPAGAPGQPMSP 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lap	NP_001163538.1	ANTH	21..298	CDD:284961	168/276 (61%)
lap	NP_001163538.1	Amelogenin	694..>773	CDD:197891	25/81 (31%)
snap91b	XP_009298297.1	ANTH	19..283	CDD:284961	168/275 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	382	1.000	Domainoid score	I788
eggNOG	1	0.900	-	-		E1_KOG0251
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1627
OMA	1	1.010	-	-		QHG56288
OrthoDB	1	1.010	-	-		D1592722at2759
OrthoFinder	1	1.000	-	-		FOG0001047
OrthoInspector	1	1.000	-	-		otm24700
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22951
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2028
SonicParanoid	1	1.000	-	-		X389
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.970