DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lap and picalmb

DIOPT Version :9

Sequence 1:	NP_001163538.1	Gene:	lap / 40863	FlyBaseID:	FBgn0086372	Length:	788	Species:	Drosophila melanogaster
Sequence 2:	XP_017214722.1	Gene:	picalmb / 445286	ZFINID:	ZDB-GENE-030131-6795	Length:	730	Species:	Danio rerio

Alignment Length:	856	Identity:	326/856 - (38%)
Similarity:	445/856 - (51%)	Gaps:	202/856 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MAGQTINDRLLAARHSLAGQGLAKSVCKATTEECIGPKKKHLDYLVHCTNEPNVSIPHLANLLIE 67
            |:||:|.||:.||:||:.|..::|:||||||.|.:||||||||||:|||||.||:||.||:.|.|
Zfish     1 MSGQSITDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIHCTNEMNVNIPQLADSLFE 65

  Fly    68 RSQNANWVVVYKSLITTHHLMAYGNERFMQYLASSNSTFNLSSFLDKGTVQDGGMGVPGGRMGYD 132
            |:.|.:||||:||||||||||.||||||:|||||.|:.||||:||||           .|..|||
Zfish    66 RTTNTSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDK-----------SGLQGYD 119

  Fly   133 MSPFIRRYAKYLNEKSLSYRAMAFDFCKVKRGKEEGSLRSMNAEKLLKTLPVLQAQLDALLEFDC 197
            ||.|||||::|||||::|||.:||||.||||| .:|.:|:||.||||||:|::|.|:||||:|:.
Zfish   120 MSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRG-VDGVMRTMNTEKLLKTIPIIQNQMDALLDFNV 183

  Fly   198 QSNDLSNGVINMSFMLLFRDLIRLFACYNDGIINLLEKYFDMNKKHARDALDLYKKFLVRMDRVG 262
            .:|:|:|||||.:|||||:|.|||||.||:||||||||||||.|...::.||:|||||.||.|:.
Zfish   184 NANELTNGVINAAFMLLFKDSIRLFAAYNEGIINLLEKYFDMKKVQCKEGLDIYKKFLTRMTRIS 248

  Fly   263 EFLKVAENVGIDKGDIPDLTK----APSSLLDALEQHLATLEGRKVSAANTPTQSSSNQRNVKSA 323
            |||||||.||||:||||||::    ||||||||||||||:|||:||..:...:::|:    :.:|
Zfish   249 EFLKVAEQVGIDRGDIPDLSQFTVCAPSSLLDALEQHLASLEGKKVKDSTAASRAST----LSNA 309

  Fly   324 VSALSSTSSAFGTAAASSKFDTTNGIDEQLKAQVLAEEEAAMNQYKSKV---------------S 373
            ||:|::|..:|            ..:||:.|...|.||:|.:...|.:.               :
Zfish   310 VSSLANTGMSF------------TKVDEREKQAALEEEQARLKALKQEQRLKELSKRPSFATTDT 362

  Fly   374 SPTSSGAAGASAALTNPFLSSPPAAQAGQPI-VDLFG-----AASAQPAAAAA--------ATKA 424
            ||.|:.||..|.|......|:|..:.....: .|||.     .:|.||..:.|        :::|
Zfish   363 SPVSTTAACISTAPAIDLFSTPSCSNGALKMESDLFDLQTNFQSSMQPGPSVATAWGDPFSSSEA 427

  Fly   425 SDDLLQLGNPFADMFDASGGGAAAVGATGFNGAS-----------------VSSAAATN------ 466
            .||.:...|||.......|.....:.:.|.:.:|                 .||:.:||
Zfish   428 VDDSIPNLNPFLSKLVVDGAHLPVMSSDGVSFSSRTSGHEIFSDQYNPFIDSSSSVSTNYKRTVR 492

  Fly   467 --AFVSDSNFSSVFGNTEPAASTSLPNPFFDDMSLPQIPLPAESVAAPFGNNINFMDQQLQQQQQ 529
              ..:|||     ||  :|:....||||                  :||         |.:....
Zfish   493 IEHLISDS-----FG--QPSMVQHLPNP------------------SPF---------QSEPSTV 523

  Fly   530 AALYVQQQQQQQLQLQQQQHRPQLPQQQAILTPSMSAAQFPPGFDALGDVLKPASASNNS----- 589
            |.|:            :....||:|       |..::.:....|::   |....:||:||
Zfish   524 AGLF------------RGYGAPQMP-------PPQNSGELRVDFES---VFGTKAASSNSLDTDA 566

  Fly   590 NQMNVVAAGYSSNSSSILALQQQQHQQHQQQHQHQLNQQQQQQPPAGTGKIITGDLDSSLMSLVD 654
            ..:....||.|.:|:                          |.|.    |:::.||||||.:||.
Zfish   567 GILKPTVAGSSQSSN--------------------------QLPE----KLVSDDLDSSLANLVG 601

  Fly   655 NLNINKTASAKPVQWNSP-KNTAKPGANWTPQPMAATTGAGYRPMAHGMTVSPAPITINHPYIHA 718
            ||.|....:...:.|:.| :.....|.||.|:...:||   :.|::...::...|.|.  |....
Zfish   602 NLGIGNGTTKNDIHWSQPGEKKLTGGMNWQPKTAPSTT---WNPVSMPPSIMAFPATT--PTGMM 661

  Fly   719 SYPVMPNYMQGMPVMGQPSMMGGQAAAPLTGVQPTMMAAPHSNATGIMQPIQPTQNGS-NKGVPL 782
            .|. ||..:..|.:|.||:||         ..||.|..   ||..|.:...||:...| :...||
Zfish   662 GYG-MPPQLPSMSMMTQPTMM---------YTQPVMRP---SNPFGSVSSAQPSAASSPSSQSPL 713

  Fly   783 -----DPFGAL 788
                 |||..|
Zfish   714 RAPGQDPFAQL 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lap	NP_001163538.1	ANTH	21..298	CDD:284961	187/280 (67%)
lap	NP_001163538.1	Amelogenin	694..>773	CDD:197891	21/78 (27%)
picalmb	XP_017214722.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577449
Domainoid	1	1.000	382	1.000	Domainoid score	I788
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1627
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1592722at2759
OrthoFinder	1	1.000	-	-		FOG0001047
OrthoInspector	1	1.000	-	-		otm24700
orthoMCL	1	0.900	-	-		OOG6_102822
Panther	1	1.100	-	-	O	PTHR22951
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X389
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900