DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lap and picalma

DIOPT Version :9

Sequence 1:	NP_001163538.1	Gene:	lap / 40863	FlyBaseID:	FBgn0086372	Length:	788	Species:	Drosophila melanogaster
Sequence 2:	XP_021334798.1	Gene:	picalma / 393901	ZFINID:	ZDB-GENE-040426-761	Length:	744	Species:	Danio rerio

Alignment Length:	847	Identity:	335/847 - (39%)
Similarity:	448/847 - (52%)	Gaps:	170/847 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MAGQTINDRLLAARHSLAGQGLAKSVCKATTEECIGPKKKHLDYLVHCTNEPNVSIPHLANLLIE 67
            |:||:|.||:.||:|.:.|..::|:||||||.|.:||||||||||:.||||.||:||.||:.|.|
Zfish     1 MSGQSITDRITAAQHIVTGSAVSKTVCKATTHEVMGPKKKHLDYLIQCTNEMNVNIPQLADTLFE 65

  Fly    68 RSQNANWVVVYKSLITTHHLMAYGNERFMQYLASSNSTFNLSSFLDKGTVQDGGMGVPGGRMGYD 132
            |:.|.:||||:||||||||||.||||||:|||||.|:.||||:||||           .|..|||
Zfish    66 RTTNTSWVVVFKSLITTHHLMVYGNERFVQYLASRNTLFNLSNFLDK-----------SGLQGYD 119

  Fly   133 MSPFIRRYAKYLNEKSLSYRAMAFDFCKVKRGKEEGSLRSMNAEKLLKTLPVLQAQLDALLEFDC 197
            ||.|||||::|||||::|||.:||||.||||| .:|.:|:||.||||||:|::|.|:||||:|:.
Zfish   120 MSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRG-ADGVMRTMNTEKLLKTIPIIQNQMDALLDFNV 183

  Fly   198 QSNDLSNGVINMSFMLLFRDLIRLFACYNDGIINLLEKYFDMNKKHARDALDLYKKFLVRMDRVG 262
            .:|:|:|||||.:|||||:|.|||||.||:||||||||||||.|...::.||:|||||.||.|:.
Zfish   184 NANELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKAQCKEGLDIYKKFLTRMTRIS 248

  Fly   263 EFLKVAENVGIDKGDIPDLTK----APSSLLDALEQHLATLEGRKVSAANTPTQSSSNQRNVKSA 323
            |||||||.||||:||||||::    ||||||||||||||:|||:||..:...:::|:    :.:|
Zfish   249 EFLKVAEQVGIDRGDIPDLSQFTVCAPSSLLDALEQHLASLEGKKVKDSTAASRAST----LSNA 309

  Fly   324 VSALSSTSSAFGTAAASSKFDTTNGIDEQLKAQVLAEEEAAMNQYK-------SKVSSPTSSGAA 381
            ||:|::|..:|..|            ||:.|...|.||:|.:...|       ||..|.||:.||
Zfish   310 VSSLANTGISFTKA------------DEREKQAALEEEQARLKALKEQRLKELSKKPSTTSTTAA 362

  Fly   382 GASAALTNPFLSSPPAAQAGQ----PIVDLFGAASAQPAAAAAATKASDDLLQLGNPFADMFDAS 442
                        ||.:.:.|.    |.:|||.|.|   ..|.:..|..:|||.|...|......|
Zfish   363 ------------SPVSTETGSISTVPAIDLFSATS---TFANSTPKVPNDLLDLQPAFQPSLPLS 412

  Fly   443 GGGAAAVGATGFNGASVSSAAATNAFVSDSNFSSVFGNTEPAASTSLPN-------PFFDDMSLP 500
            .|...|                       :.:...|.:|| ||..|:||       |..|.:.||
Zfish   413 SGLPLA-----------------------NTWGDPFTSTE-AADDSIPNLNPFLTKPVVDPVHLP 453

  Fly   501 QIPLPAESVAA------PFGNNIN-FMDQQLQQQQQAALYVQQQQQQQLQLQQQQHRPQLPQQQA 558
            .:...|.|.::      .||:|.| |:|    .....|..|:........|......|.......
Zfish   454 VVSSDAVSFSSRTPSHEMFGDNYNPFID----SSSSVASPVEPPVGMGCFLSDSFCSPTAYPNTP 514

  Fly   559 IL--TPSMSAAQFPPGFDALGDVLKPASASNNSNQMNV---------VAAGYSSNSSSILA--LQ 610
            :.  .||..|..| .||.|     .||:...:|..:||         ..|..:.::..||.  |:
Zfish   515 LFHSEPSTVAGLF-GGFSA-----PPAAQPPSSTGLNVDFDSVFGNKSVANSTDSADDILGGILK 573

  Fly   611 QQQHQQHQQQHQHQLNQQQQQQPPAG--TGKIITGDLDSSLMSLVDNLNINKTASAKPVQWNSP- 672
            .            .:....|...|:.  :||:::.||||||.:||.||.|....:...:.|:.|
Zfish   574 P------------TVTSPNQGLTPSAQLSGKLVSDDLDSSLANLVGNLGIGNGTAKNDIHWSQPG 626

  Fly   673 KNTAKPGANWTPQPMAATTGAGYRPMAHGMTVSP--APITINHPYIHASYP------VMPNYMQG 729
            :.....|.||.|:....||   :.|......:.|  ||..:..|   |:.|      .||..|..
Zfish   627 EKKLTGGMNWQPKTAPTTT---WNPATMNGMLFPQYAPSVMAFP---ATTPTGMMGYAMPPQMGS 685

  Fly   730 MPVMGQPSMMGGQAA-------APLTGVQPTMMAAPHSNATGIMQPIQ-PTQNGSNKGVPLDPFG 786
            |.:|.||:||..|..       .|::|.|.:..::|.|::     |:: |.|         |||.
Zfish   686 MAMMTQPTMMYTQPVMRPANPFGPVSGAQLSTASSPSSSS-----PLRAPGQ---------DPFA 736

  Fly   787 AL 788
            .|
Zfish   737 QL 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lap	NP_001163538.1	ANTH	21..298	CDD:284961	186/280 (66%)
lap	NP_001163538.1	Amelogenin	694..>773	CDD:197891	24/94 (26%)
picalma	XP_021334798.1	ANTH	24..286	CDD:311541	183/273 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577448
Domainoid	1	1.000	382	1.000	Domainoid score	I788
eggNOG	1	0.900	-	-		E1_KOG0251
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111783
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1627
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1592722at2759
OrthoFinder	1	1.000	-	-		FOG0001047
OrthoInspector	1	1.000	-	-		otm24700
orthoMCL	1	0.900	-	-		OOG6_102822
Panther	1	1.100	-	-	LDO	PTHR22951
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2028
SonicParanoid	1	1.000	-	-		X389
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790