DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lap and unc-11

DIOPT Version :9

Sequence 1:	NP_001163538.1	Gene:	lap / 40863	FlyBaseID:	FBgn0086372	Length:	788	Species:	Drosophila melanogaster
Sequence 2:	NP_001361961.1	Gene:	unc-11 / 171952	WormBaseID:	WBGene00006751	Length:	642	Species:	Caenorhabditis elegans

Alignment Length:	789	Identity:	315/789 - (39%)
Similarity:	398/789 - (50%)	Gaps:	166/789 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TMAGQTINDRLLAARHSLAGQGLAKSVCKATTEECIGPKKKHLDYLVHCTNEPNVSIPHLANLLI 66
            |..||||:|||.||:|||||..|.|::|||||||.:.|||||||||:|||||||||||.:|||||
Worm    15 TTGGQTISDRLTAAKHSLAGSQLGKTICKATTEEVMAPKKKHLDYLLHCTNEPNVSIPSMANLLI 79

  Fly    67 ERSQNANWVVVYKSLITTHHLMAYGNERFMQYLASSNSTFNLSSFLDKGTVQDGGMGVPGGRMGY 131
            ||:||.||.||||:|||.|::|.||||||.|||||.|:||||::|:||          .||..||
Worm    80 ERTQNPNWTVVYKALITIHNIMCYGNERFSQYLASCNTTFNLTAFVDK----------VGGAGGY 134

  Fly   132 DMSPFIRRYAKYLNEKSLSYRAMAFDFCKVKRGKEEGSLRSMNAEKLLKTLPVLQAQLDALLEFD 196
            |||..:||||||:.||..:||..||||||||||:|:|.||:|:.:|||||:|:||.|:||||||.
Worm   135 DMSTHVRRYAKYIGEKINTYRMCAFDFCKVKRGREDGLLRTMHTDKLLKTIPILQNQIDALLEFS 199

  Fly   197 CQSNDLSNGVINMSFMLLFRDLIRLFACYNDGIINLLEKYFDMNKKHARDALDLYKKFLVRMDRV 261
            ..:::|:|||||.||:|||||||||||||||||||:||||||||||..|||||.||.||.|:|:|
Worm   200 VTTSELNNGVINCSFILLFRDLIRLFACYNDGIINVLEKYFDMNKKQCRDALDTYKSFLTRLDKV 264

  Fly   262 GEFLKVAENVGIDKGDIPDLTKAPSSLLDALEQHLATLEGRKVSAANTPTQSSSNQRNVKSAVSA 326
            .|||:|||:||||:|:|||||:||:|||:|||.||..|||.|   |..|||.........:..:.
Worm   265 AEFLRVAESVGIDRGEIPDLTRAPASLLEALEAHLIHLEGGK---APPPTQQHVAPHQFTTGFAF 326

  Fly   327 LSSTSSAFGTAAASSKFDTTNGIDEQLKAQVLAEEEAAMNQYKSKVSSPTSSGAAGASAALTNPF 391
            ......|.|.|.               :.:.:..|:..:.|::.:..|..|:          |||
Worm   327 SQQPQPALGDAE---------------RQRYIELEQERLRQFEDQKKSINSA----------NPF 366

  Fly   392 LSSPPAAQAGQPIVDLFGAASAQPAAAAAATKASDDLLQLGNPFADMFDASGGGAAAVGATGFNG 456
            .:.               .|||.||.|.:|  |..|||       |||.:|...|.
Worm   367 AND---------------VASAAPAPATSA--AQPDLL-------DMFQSSAAPAP--------- 398

  Fly   457 ASVSSAAATNAFVSDSNFSSVFGNTEPAASTSLPNPFFDDMSLPQIPLPAESVAAPFGNNINFMD 521
               .:|..||.|   .||         ||.::.|.         .:|.|| :.:||||      .
Worm   399 ---QTADVTNPF---GNF---------AAPSAFPT---------NVPPPA-AHSAPFG------V 432

  Fly   522 QQLQQQQQAALYVQQQQQQQLQLQQQQHRPQLPQQQAILTPSMSAAQFPPGFDALGDVLKPASAS 586
            |...|...|..|....|...:| .|..:.|:.|...|...|.|..|  ||       |..|.::.
Worm   433 QPAPQHSAAPFYANLHQAPPMQ-SQAPNEPENPFITAPAAPQMHNA--PP-------VPPPPASQ 487

  Fly   587 NNSNQMNVVAAGYSSNSSSILALQQQQHQQHQQQHQHQLNQQQQQQPPAGTGKIITGDLDSSLMS 651
            .....:|..|...::.:||........|                |..|.|.......|    |..
Worm   488 GAPAPINPFADPSATAASSAQPFGDPGH----------------QAAPFGYPNAHPDD----LAR 532

  Fly   652 LVDNLNINKTASAKPVQWNSPKNTAKP---GANWTPQPM-AATTGAGYRPMAHGMTVSPAPITIN 712
            :...:::|:.....|..||:..:....   ||...|||| .|..|...:|.......:||
Worm   533 MTAQMSLNQQGYRAPAGWNTTTSAVSNNPFGATSAPQPMYTAPMGMYQQPFGAQPMWNPA----- 592

  Fly   713 HPYIHASYPVMPNYMQGMPVMGQPSMMGGQAAAPLTGVQPTMMAAPHSNATGIMQPIQPTQNGSN 777
                .|:|.....|.|.:|...|..:....||          |||  .||....|.
Worm   593 ----MAAYGQQYGYGQPVPPQQQHQIQLVHAA----------MAA--KNAAQAQQA--------- 632

  Fly   778 KGVPLDPFG 786
            :....||||
Worm   633 QAASADPFG 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lap	NP_001163538.1	ANTH	21..298	CDD:284961	191/276 (69%)
lap	NP_001163538.1	Amelogenin	694..>773	CDD:197891	17/78 (22%)
unc-11	NP_001361961.1	ANTH_N_AP180	37..154	CDD:340782	83/126 (66%)
unc-11	NP_001361961.1	MISS	392..588	CDD:318115	58/265 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158215
Domainoid	1	1.000	396	1.000	Domainoid score	I381
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	442	1.000	Inparanoid score	I927
Isobase	1	0.950	-	0	Normalized mean entropy	S2368
OMA	1	1.010	-	-		QHG56288
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001047
OrthoInspector	1	1.000	-	-		oto18731
orthoMCL	1	0.900	-	-		OOG6_102822
Panther	1	1.100	-	-	LDO	PTHR22951
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2028
SonicParanoid	1	1.000	-	-		X389
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.880