DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lap and wu:fj42b12

DIOPT Version :9

Sequence 1:	NP_001163538.1	Gene:	lap / 40863	FlyBaseID:	FBgn0086372	Length:	788	Species:	Drosophila melanogaster
Sequence 2:	NP_001353626.1	Gene:	wu:fj42b12 / 100005187	ZFINID:	ZDB-GENE-030131-7935	Length:	553	Species:	Danio rerio

Alignment Length:	784	Identity:	280/784 - (35%)
Similarity:	372/784 - (47%)	Gaps:	248/784 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MAGQTINDRLLAARHSLAGQGLAKSVCKATTEECIGPKKKHLDYLVHCTNEPNVSIPHLANLLIE 67
            |:||:|.||:.||:||:.|..::|:||||||.|...|||||||||:||||:.||:|||||:.|.|
Zfish     1 MSGQSITDRIAAAQHSMTGSAISKAVCKATTHEVSAPKKKHLDYLMHCTNDVNVNIPHLADTLFE 65

  Fly    68 RSQNANWVVVYKSLITTHHLMAYGNERFMQYLASSNSTFNLSSFLDKGTVQDGGMGVPGGRMGYD 132
            |:.|.:||||:|:||||||||.||||||:|||||.::.|||::|:|||.:|           |||
Zfish    66 RTANQSWVVVFKALITTHHLMMYGNERFIQYLASRSTLFNLNNFVDKGALQ-----------GYD 119

  Fly   133 MSPFIRRYAKYLNEKSLSYRAMAFDFCKVKRGKEEGSLRSMNAEKLLKTLPVLQAQLDALLEFDC 197
            ||.:||||::||.|::||||.:|.||.|:||| .:|.:|:|:.|||:||||:.|.||||||:|:.
Zfish   120 MSIYIRRYSRYLTERALSYRLVAADFTKMKRG-TDGVMRTMSIEKLMKTLPITQNQLDALLDFEA 183

  Fly   198 QSNDLSNGVINMSFMLLFRDLIRLFACYNDGIINLLEKYFDMNKKHARDALDLYKKFLVRMDRVG 262
            .|.:|:|||||.:|.|||:|.||:||.||:|:||||||||:|.|...::||::||:|||||.::.
Zfish   184 SSTELTNGVINCAFTLLFKDSIRIFAAYNEGVINLLEKYFNMKKNQCKEALEIYKRFLVRMTKLS 248

  Fly   263 EFLKVAENVGIDKGDIPDLTKAPSSLLDALEQHLATLEGRKVSAANTPTQSSSNQRNVKSAVSAL 327
            |||||||.||||:.|||||::||||||:|||||||:|||:|:..|:|.::.....|...:....|
Zfish   249 EFLKVAEQVGIDQVDIPDLSQAPSSLLEALEQHLASLEGKKMKDASTVSREVEGDRLQPAKAVQL 313

  Fly   328 SSTSSAFGTAAASSKFDTTNGIDEQLKAQVLAEEEAAMNQYKSKVSSPTSSGAAGASAALTNPFL 392
            ........|.:.|.:                        ...|..||.|||||        ...|
Zfish   314 KDIGMQTPTVSPSGQ------------------------SVGSANSSCTSSGA--------TELL 346

  Fly   393 SSPPAAQAGQPIVDLFGAASAQPAAAAAATKASDDLLQLGNPFADMFDASGGGAAAVGATGFNGA 457
            ||||                              ||                       |..||.
Zfish   347 SSPP------------------------------DL-----------------------TITNGV 358

  Fly   458 SVSSAAATNAFVSDSNFSSVFGNTEPAASTSLPNPFFDDMSLPQIPLPAESVAAPFGNNINFMDQ 522
                          .||:               |..||
Zfish   359 --------------HNFT---------------NDHFD--------------------------- 367

  Fly   523 QLQQQQQAALYVQQQQQQQLQLQQQQHRPQLPQQQAILTPSMSAAQFPPGFDALGDVLKPASASN 587
                                    .||....|.|    |.::.|:....|    |.:|||.
Zfish   368 ------------------------LQHNSSTPAQ----TNTLPASNNSWG----GALLKPT---- 396

  Fly   588 NSNQMNVVAAGYSSNSSSILALQQQQHQQHQQQHQHQLNQQQQQQPPAGT-----GKIITGDLDS 647
                                                 |:.|.|.|   ||     ||::|.||||
Zfish   397 -------------------------------------LSTQVQSQ---GTQFYNGGKLLTNDLDS 421

  Fly   648 SLMSLVDNLNINKTASAKP-VQWNSPKNTAKPGANWTPQPMAATTGAGYRPMAHGMTVSPAPITI 711
            ||.:||.||:.....:.|| |||...:..:..|::|..:.|..|.     |.:| ..::||||.:
Zfish   422 SLANLVGNLHFGGPPAKKPEVQWTHLEKKSSGGSHWQTKAMNGTA-----PWSH-THLAPAPIPM 480

  Fly   712 --NHPYIHASY---PV-MPNYMQGMPVMGQ-PSMMGGQAAAPLTGVQPTMMAAPHSNATGIMQPI 769
              .:..|:..|   || .|.....:||.|. |..:|...:.||...||.:...|....|....||
Zfish   481 PQMNGMIYTGYAPAPVAFPMTTPQVPVYGMIPPPVGQMGSVPLMAPQPVIYNQPILRTTNPFTPI 545

  Fly   770 QPTQ 773
            ...|
Zfish   546 PGAQ 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lap	NP_001163538.1	ANTH	21..298	CDD:284961	172/276 (62%)
lap	NP_001163538.1	Amelogenin	694..>773	CDD:197891	24/85 (28%)
wu:fj42b12	NP_001353626.1	ANTH	21..282	CDD:311541	169/272 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0251
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1592722at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.800