DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sas and CCN4

DIOPT Version :9

Sequence 1:	NP_001262337.1	Gene:	sas / 40861	FlyBaseID:	FBgn0002306	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_003873.1	Gene:	CCN4 / 8840	HGNCID:	12769	Length:	367	Species:	Homo sapiens

Alignment Length:	360	Identity:	85/360 - (23%)
Similarity:	113/360 - (31%)	Gaps:	116/360 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   610 TVVATEGAAPSTNGTGESAVTL---PTTDDEATPKPRTDCHYNSGVYKFRERLEIGCEQICHCAE 671
            |:.|...||.||    ..|..|   |||.| .||.|..|   .|...:|       |:..|.|..
Human     8 TLAAVTAAAAST----VLATALSPAPTTMD-FTPAPLED---TSSRPQF-------CKWPCECPP 57

  Fly   672 GGVMDCRPRCPERNHTRLDKCVYVKDPKDVCCQLELCDVTLDDHEQQPTPLQSNNNEDPEEIDPF 736
            .     .||||.......|.|        .||  ::|...|.|           |..:....||.
Human    58 S-----PPRCPLGVSLITDGC--------ECC--KMCAQQLGD-----------NCTEAAICDPH 96

  Fly   737 RFQEQARDAGGAKPT-------------CTFKGAEYDVGQQFRDGCDQLCICNEQGIHCAKLECP 788
            |  ....|..|.:|.             |...|..|:.||.|:..|...|.|.:..:.|..| |
Human    97 R--GLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPL-C- 157

  Fly   789 SNFGLDVQDPHCIRWEPVPADFKPSPPNCCPESMRCVDNG----------TCSYQGV-QIE---- 838
                |.|:.|..  |.|.|.  :.|.|..|.|...|.|:.          |.::..| ::|
Human   158 ----LRVRPPRL--WCPHPR--RVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHR 214

  Fly   839 -------NWSP--------VPANLTGCDQHCYCENGRVECRAACPPVPALPPADLPCHPAL---A 885
                   .|||        |...::..:..|:.|.....|.        |.|.|:..|..:   .
Human   215 NCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCN--------LRPCDVDIHTLIKAGK 271

  Fly   886 RLLPIPDDECCKHWMCAPQI------PKIGGAGQD 914
            :.|.:...|...::..|..|      ||..|...|
Human   272 KCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMD 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sas	NP_001262337.1	VWC	752..824	CDD:214564	22/71 (31%)
		fn3	1413..1479	CDD:278470
		FN3	1516..1605	CDD:238020
CCN4	NP_003873.1	IGFBP	49..101	CDD:365955	18/79 (23%)
		VWC	123..181	CDD:214564	21/67 (31%)
		TSP1	220..260	CDD:214559	9/47 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11348
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100